FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788763019> ?p ?o ?g. }

• W2788763019 abstract "Aberrant blood vessel formation and hemorrhage may contribute to tumor progression and are potential targets in the treatment of several types of cancer. Pancreatic neuroendocrine tumors (PNETs) are highly vascularized, particularly when they are well-differentiated. However, the process of vascularization and endothelial cell detachment in PNETs is poorly understood. In the present study, 132 PNET clinical samples were examined and a special type of hemorrhagic region was observed in ~30% of the samples regardless of tumor subtype. These hemorrhagic regions were presented as blood-filled caverns with a smooth boundary and were unlined by endothelial cells. Based on the extensive endothelial cell detachment observed in the clinical samples, the formation process of these blood-filled caverns was hypothesized. Blood vessel dilation followed by detachment of endothelial cells from the surrounding tumor tissue was speculated. This was further supported using an INS-1 xenograft insulinoma model. As the formation process was distinct from the typical diffusive hemorrhage, it was named 'pseudo-hemorrhage'. Furthermore, it was demonstrated that epithelial (E-) cadherin and β-catenin were overexpressed in tumor cells surrounding these pseudo-hemorrhagic regions. Therefore, even though no statistically significant association of pseudo-hemorrhage with clinical features (metastasis or disease recurrence) was identified, the high levels of E-cadherin and β-catenin expression may suggest that a number of features of normal islet cells are retained." @default.
• W2788763019 created "2018-03-06" @default.
• W2788763019 creator A5002196970 @default.
• W2788763019 creator A5009435619 @default.
• W2788763019 creator A5020498956 @default.
• W2788763019 creator A5030941717 @default.
• W2788763019 creator A5034673131 @default.
• W2788763019 creator A5037274976 @default.
• W2788763019 creator A5044867102 @default.
• W2788763019 creator A5048236951 @default.
• W2788763019 creator A5050333823 @default.
• W2788763019 creator A5051380367 @default.
• W2788763019 creator A5065342121 @default.
• W2788763019 creator A5070697772 @default.
• W2788763019 creator A5089189494 @default.
• W2788763019 date "2018-01-22" @default.
• W2788763019 modified "2023-10-15" @default.
• W2788763019 title "Pseudo-hemorrhagic region formation in pancreatic neuroendocrine tumors is a result of blood vessel dilation followed by endothelial cell detachment" @default.
• W2788763019 cites W1539571840 @default.
• W2788763019 cites W1550148342 @default.
• W2788763019 cites W175938947 @default.
• W2788763019 cites W1964081206 @default.
• W2788763019 cites W1968572157 @default.
• W2788763019 cites W1975480650 @default.
• W2788763019 cites W1995034367 @default.
• W2788763019 cites W1997379173 @default.
• W2788763019 cites W2004313228 @default.
• W2788763019 cites W2009350518 @default.
• W2788763019 cites W2025036947 @default.
• W2788763019 cites W2053262936 @default.
• W2788763019 cites W2057103712 @default.
• W2788763019 cites W2063720970 @default.
• W2788763019 cites W2065468887 @default.
• W2788763019 cites W2074877198 @default.
• W2788763019 cites W2095174227 @default.
• W2788763019 cites W2109661734 @default.
• W2788763019 cites W2113214449 @default.
• W2788763019 cites W2144187890 @default.
• W2788763019 cites W2145470537 @default.
• W2788763019 cites W2146857566 @default.
• W2788763019 cites W2156113506 @default.
• W2788763019 cites W2158474413 @default.
• W2788763019 cites W2162036268 @default.
• W2788763019 cites W226609814 @default.
• W2788763019 cites W2338022213 @default.
• W2788763019 cites W46585636 @default.
• W2788763019 cites W89877170 @default.
• W2788763019 doi "https://doi.org/10.3892/ol.2018.7840" @default.
• W2788763019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5835859" @default.
• W2788763019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29541192" @default.
• W2788763019 hasPublicationYear "2018" @default.
• W2788763019 type Work @default.
• W2788763019 sameAs 2788763019 @default.
• W2788763019 citedByCount "2" @default.
• W2788763019 countsByYear W27887630192019 @default.
• W2788763019 countsByYear W27887630192022 @default.
• W2788763019 crossrefType "journal-article" @default.
• W2788763019 hasAuthorship W2788763019A5002196970 @default.
• W2788763019 hasAuthorship W2788763019A5009435619 @default.
• W2788763019 hasAuthorship W2788763019A5020498956 @default.
• W2788763019 hasAuthorship W2788763019A5030941717 @default.
• W2788763019 hasAuthorship W2788763019A5034673131 @default.
• W2788763019 hasAuthorship W2788763019A5037274976 @default.
• W2788763019 hasAuthorship W2788763019A5044867102 @default.
• W2788763019 hasAuthorship W2788763019A5048236951 @default.
• W2788763019 hasAuthorship W2788763019A5050333823 @default.
• W2788763019 hasAuthorship W2788763019A5051380367 @default.
• W2788763019 hasAuthorship W2788763019A5065342121 @default.
• W2788763019 hasAuthorship W2788763019A5070697772 @default.
• W2788763019 hasAuthorship W2788763019A5089189494 @default.
• W2788763019 hasBestOaLocation W27887630191 @default.
• W2788763019 hasConcept C121608353 @default.
• W2788763019 hasConcept C123012128 @default.
• W2788763019 hasConcept C126322002 @default.
• W2788763019 hasConcept C142724271 @default.
• W2788763019 hasConcept C202751555 @default.
• W2788763019 hasConcept C2776992346 @default.
• W2788763019 hasConcept C2777663904 @default.
• W2788763019 hasConcept C2779013556 @default.
• W2788763019 hasConcept C2779066768 @default.
• W2788763019 hasConcept C29537977 @default.
• W2788763019 hasConcept C55493867 @default.
• W2788763019 hasConcept C67082663 @default.
• W2788763019 hasConcept C71924100 @default.
• W2788763019 hasConcept C86803240 @default.
• W2788763019 hasConceptScore W2788763019C121608353 @default.
• W2788763019 hasConceptScore W2788763019C123012128 @default.
• W2788763019 hasConceptScore W2788763019C126322002 @default.
• W2788763019 hasConceptScore W2788763019C142724271 @default.
• W2788763019 hasConceptScore W2788763019C202751555 @default.
• W2788763019 hasConceptScore W2788763019C2776992346 @default.
• W2788763019 hasConceptScore W2788763019C2777663904 @default.
• W2788763019 hasConceptScore W2788763019C2779013556 @default.
• W2788763019 hasConceptScore W2788763019C2779066768 @default.
• W2788763019 hasConceptScore W2788763019C29537977 @default.
• W2788763019 hasConceptScore W2788763019C55493867 @default.
• W2788763019 hasConceptScore W2788763019C67082663 @default.
• W2788763019 hasConceptScore W2788763019C71924100 @default.
• W2788763019 hasConceptScore W2788763019C86803240 @default.
• W2788763019 hasLocation W27887630191 @default.

• next