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- W2788771374 abstract "The role of polyomavirus BK (BKV) large tumor antigen (L-Tag) as target of tumor immune surveillance in prostate cancer (PCa) patients has not been investigated so far. We thus analyzed the immunological profile exerted by L-Tag peptide-specific induction in newly diagnosed PCa patients, as compared to age-matched benign prostatic hyperplasia (BPH) patients, in relation to BKV L-Tag serology and urine molecular testing. We proposed here a comprehensive analysis of CTL response against BKV large T antigen-related epitopes in BKV-seropositive patients bearing prostate preneoplastic or neoplastic lesions irrespective of their HLA typing. We thus attempted the identification and characterization of antigen-specific immune responses against BKV L-Tag-peptides in either CD4+ or CD8+ T cells comparing functional features of peptide-expanded T cells in BKV seropositive PCa patients, aged-matched BPH, gendermatched healthy donors. Similarly, we investigated the efficiency of BKV L-Tag peptide-stimulated T cells to exert a cytotoxic activity against peptide-pulsed target cells across a wide range of HLA class I and II antigens." @default.
- W2788771374 created "2018-03-06" @default.
- W2788771374 creator A5040575472 @default.
- W2788771374 date "2011-01-01" @default.
- W2788771374 modified "2023-09-23" @default.
- W2788771374 title "Comprehensive characterization of BKV large T antigen epitopes to promote the expansion of effectors T lymphocytes across a wide range of HLA class I and II antigens in prostate cancer patients" @default.
- W2788771374 doi "https://doi.org/10.5167/uzh-51102" @default.
- W2788771374 hasPublicationYear "2011" @default.
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