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• W2788792358 abstract "Diarrheal disease is the most common infection afflicting children worldwide. In resource-poor settings, these infections are correlated with cognitive delay, stunted growth, and premature death. With the development of efficacious, affordable, and easily administered vaccines, such infections could be prevented. While a major focus of research on biofilms has been their elimination, here we harness the bacterial biofilm to create a customizable platform for cost-effective, whole-cell mucosal vaccines that self-incorporate secreted protein antigens. We use this platform to develop a sublingually administered live-attenuated prototype vaccine based on Vibrio cholerae . This serves not only as a proof of concept for a multivalent vaccine against common bacterial enteric pathogens but also as a paradigm for vaccines utilizing other bacterial biofilms to target mucosal infections." @default.
• W2788792358 created "2018-03-06" @default.
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• W2788792358 date "2018-08-01" @default.
• W2788792358 modified "2023-10-12" @default.
• W2788792358 title "A Self-Assembling Whole-Cell Vaccine Antigen Presentation Platform" @default.
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• W2788792358 doi "https://doi.org/10.1128/jb.00752-17" @default.
• W2788792358 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6040178" @default.
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• W2788792358 hasPublicationYear "2018" @default.
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