FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788793405> ?p ?o ?g. }

• W2788793405 abstract "Patients with peripheral artery disease show an exaggerated pressor response to mild exercise, an effect attributable to the exercise pressor reflex, whose afferent arm comprises the thinly myelinated group III and unmyelinated group IV afferents. Previously, we found that DAMGO, a µ-opioid agonist injected into the femoral artery, attenuated the exaggerated exercise pressor reflex in rats with ligated femoral arteries, a preparation that simulates the blood flow patterns to muscle that is seen in patients with peripheral artery disease. Continuing this line of investigation, we recorded the responses of group III and IV afferents to static contraction before and after injecting DAMGO (1 µg) into the superficial epigastric artery in rats with patent femoral arteries and in rats with ligated femoral arteries. In rats with patent arteries, DAMGO did not change the responses to contraction of either group III ( n = 9; P = 0.83) or group IV ( n = 8; P = 0.34) afferents. In contrast, in rats with ligated femoral arteries, DAMGO injection (1 µg) significantly decreased the responses to contraction of both group III afferents ( n = 9, P < 0.01) and group IV afferents ( n = 9; P < 0.01). DAMGO did not significantly attenuate the responses of either group III or IV afferents to capsaicin in rats with either patent or ligated femoral arteries. These findings are in agreement with our previous studies that showed that peripheral DAMGO injection attenuated the exercise pressor reflex in rats with ligated femoral arteries but had only a modest effect on the exercise pressor reflex in rats with patent femoral arteries. NEW & NOTEWORTHY In an animal model of peripheral artery disease, we show that the µ-opioid agonist, DAMGO reduces the afferent response rate resulting from stimulated static contraction. These results suggest that peripherally active opioid agonists that do not cross the blood-brain barrier may be therapeutic for treatment of peripheral artery disease without the negative and addictive side effects associated with opioids in the central nervous system." @default.
• W2788793405 created "2018-03-06" @default.
• W2788793405 creator A5004382964 @default.
• W2788793405 creator A5075020929 @default.
• W2788793405 creator A5091881806 @default.
• W2788793405 date "2018-06-01" @default.
• W2788793405 modified "2023-10-15" @default.
• W2788793405 title "Peripheral µ-opioid receptors attenuate the responses of group III and IV afferents to contraction in rats with simulated peripheral artery disease" @default.
• W2788793405 cites W130143018 @default.
• W2788793405 cites W1575871050 @default.
• W2788793405 cites W1604958534 @default.
• W2788793405 cites W1965036294 @default.
• W2788793405 cites W1976950263 @default.
• W2788793405 cites W2002092544 @default.
• W2788793405 cites W2003984065 @default.
• W2788793405 cites W2005486831 @default.
• W2788793405 cites W2024705528 @default.
• W2788793405 cites W2034721936 @default.
• W2788793405 cites W2045032238 @default.
• W2788793405 cites W2056453954 @default.
• W2788793405 cites W2069763385 @default.
• W2788793405 cites W2081323341 @default.
• W2788793405 cites W2085917484 @default.
• W2788793405 cites W2087252312 @default.
• W2788793405 cites W2095971269 @default.
• W2788793405 cites W2107433166 @default.
• W2788793405 cites W2118250164 @default.
• W2788793405 cites W2125049040 @default.
• W2788793405 cites W2131404925 @default.
• W2788793405 cites W2166780619 @default.
• W2788793405 cites W2290999222 @default.
• W2788793405 cites W2760957340 @default.
• W2788793405 cites W2782794273 @default.
• W2788793405 doi "https://doi.org/10.1152/jn.00034.2018" @default.
• W2788793405 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6032119" @default.
• W2788793405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29465323" @default.
• W2788793405 hasPublicationYear "2018" @default.
• W2788793405 type Work @default.
• W2788793405 sameAs 2788793405 @default.
• W2788793405 citedByCount "3" @default.
• W2788793405 countsByYear W27887934052019 @default.
• W2788793405 countsByYear W27887934052020 @default.
• W2788793405 countsByYear W27887934052021 @default.
• W2788793405 crossrefType "journal-article" @default.
• W2788793405 hasAuthorship W2788793405A5004382964 @default.
• W2788793405 hasAuthorship W2788793405A5075020929 @default.
• W2788793405 hasAuthorship W2788793405A5091881806 @default.
• W2788793405 hasBestOaLocation W27887934051 @default.
• W2788793405 hasConcept C126322002 @default.
• W2788793405 hasConcept C134018914 @default.
• W2788793405 hasConcept C163415756 @default.
• W2788793405 hasConcept C170493617 @default.
• W2788793405 hasConcept C2776401185 @default.
• W2788793405 hasConcept C2778938600 @default.
• W2788793405 hasConcept C2779723990 @default.
• W2788793405 hasConcept C2779886867 @default.
• W2788793405 hasConcept C42219234 @default.
• W2788793405 hasConcept C46762472 @default.
• W2788793405 hasConcept C71924100 @default.
• W2788793405 hasConcept C83974742 @default.
• W2788793405 hasConceptScore W2788793405C126322002 @default.
• W2788793405 hasConceptScore W2788793405C134018914 @default.
• W2788793405 hasConceptScore W2788793405C163415756 @default.
• W2788793405 hasConceptScore W2788793405C170493617 @default.
• W2788793405 hasConceptScore W2788793405C2776401185 @default.
• W2788793405 hasConceptScore W2788793405C2778938600 @default.
• W2788793405 hasConceptScore W2788793405C2779723990 @default.
• W2788793405 hasConceptScore W2788793405C2779886867 @default.
• W2788793405 hasConceptScore W2788793405C42219234 @default.
• W2788793405 hasConceptScore W2788793405C46762472 @default.
• W2788793405 hasConceptScore W2788793405C71924100 @default.
• W2788793405 hasConceptScore W2788793405C83974742 @default.
• W2788793405 hasFunder F4320332161 @default.
• W2788793405 hasLocation W27887934051 @default.
• W2788793405 hasLocation W27887934052 @default.
• W2788793405 hasLocation W27887934053 @default.
• W2788793405 hasLocation W27887934054 @default.
• W2788793405 hasOpenAccess W2788793405 @default.
• W2788793405 hasPrimaryLocation W27887934051 @default.
• W2788793405 hasRelatedWork W1966504330 @default.
• W2788793405 hasRelatedWork W1966769650 @default.
• W2788793405 hasRelatedWork W2028226107 @default.
• W2788793405 hasRelatedWork W2037631372 @default.
• W2788793405 hasRelatedWork W2053026193 @default.
• W2788793405 hasRelatedWork W2069586323 @default.
• W2788793405 hasRelatedWork W2169383879 @default.
• W2788793405 hasRelatedWork W2635788702 @default.
• W2788793405 hasRelatedWork W3114904461 @default.
• W2788793405 hasRelatedWork W3169133646 @default.
• W2788793405 isParatext "false" @default.
• W2788793405 isRetracted "false" @default.
• W2788793405 magId "2788793405" @default.
• W2788793405 workType "article" @default.