FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788889448> ?p ?o ?g. }

• W2788889448 endingPage "31" @default.
• W2788889448 startingPage "25" @default.
• W2788889448 abstract "Cancer vaccines mostly aim to induce cytotoxic T lymphocytes (CTLs) against tumors. An appropriate adjuvant is of fundamental importance for inducing cellular immune response. Since the antigen in particulate form is substantially more immunogenic than soluble form antigen, it is beneficial to interact with antigen-presenting cells membrane to induce robust CD8+ T cell activation following vaccination. Based on previous research, we designed an adjuvant formulation by combining Astragalus saponins, cholesterol, and liposome to incorporate antigen into a particulate delivery system, so as to enhance cellular immune response. Meanwhile, angiogenesis contributes to tumor growth and metastasis, and basic fibroblast growth factor (bFGF) is involved in tumor angiogenesis. Therefore, using lipo-saponins adjuvant formulation and a human recombinant bFGF antigen protein, we tried to induce bFGF-specific CTL response to inhibit tumor angiogenesis to achieve antitumor activity. After five immunizations, the lipo-saponins/bFGF complex elicited robust antibody response and markedly higher amount of interferon-γ in BALB/c mice, resulting in superior antitumor activities. Decreased microvessel density in CD31 immunohistochemistry and the lysis of vascular endothelial cells by the T lymphocytes from the immunized mice indicated that the immunity inhibited the angiogenesis of tumors and further led to the inhibition of tumors. Our data suggest that the approach to construct adjuvant formulation between liposome and Astragalus saponins appeared highly desirable, and that Astragalus saponins may be utilized as a valuable additive for enhancing the effectiveness of vaccines and stimulating an appropriate immune response that can benefit tumor therapy." @default.
• W2788889448 created "2018-03-06" @default.
• W2788889448 creator A5013959664 @default.
• W2788889448 creator A5019120402 @default.
• W2788889448 creator A5021185518 @default.
• W2788889448 creator A5026061886 @default.
• W2788889448 creator A5028467654 @default.
• W2788889448 creator A5041799538 @default.
• W2788889448 creator A5046000864 @default.
• W2788889448 creator A5053216149 @default.
• W2788889448 creator A5065273787 @default.
• W2788889448 creator A5068851161 @default.
• W2788889448 creator A5089893665 @default.
• W2788889448 creator A5091198078 @default.
• W2788889448 date "2018-02-01" @default.
• W2788889448 modified "2023-10-05" @default.
• W2788889448 title "<i>Astragalus</i>Saponins and Liposome Constitute an Efficacious Adjuvant Formulation for Cancer Vaccines" @default.
• W2788889448 cites W1545819550 @default.
• W2788889448 cites W1564780530 @default.
• W2788889448 cites W1922307675 @default.
• W2788889448 cites W1965094170 @default.
• W2788889448 cites W1973776347 @default.
• W2788889448 cites W1978475358 @default.
• W2788889448 cites W1994796659 @default.
• W2788889448 cites W1998462329 @default.
• W2788889448 cites W2006530173 @default.
• W2788889448 cites W2007105570 @default.
• W2788889448 cites W2014339619 @default.
• W2788889448 cites W2016831314 @default.
• W2788889448 cites W2017659498 @default.
• W2788889448 cites W2020920166 @default.
• W2788889448 cites W2022540958 @default.
• W2788889448 cites W2025372248 @default.
• W2788889448 cites W2032006692 @default.
• W2788889448 cites W2032489945 @default.
• W2788889448 cites W2033905138 @default.
• W2788889448 cites W2035143278 @default.
• W2788889448 cites W2050319456 @default.
• W2788889448 cites W2052877553 @default.
• W2788889448 cites W2062879186 @default.
• W2788889448 cites W2070377914 @default.
• W2788889448 cites W2071549298 @default.
• W2788889448 cites W2078473516 @default.
• W2788889448 cites W2080667413 @default.
• W2788889448 cites W2082402090 @default.
• W2788889448 cites W2083811717 @default.
• W2788889448 cites W2085117944 @default.
• W2788889448 cites W2085165735 @default.
• W2788889448 cites W2102674135 @default.
• W2788889448 cites W2116293732 @default.
• W2788889448 cites W2135221251 @default.
• W2788889448 cites W2144887013 @default.
• W2788889448 cites W2152367839 @default.
• W2788889448 cites W2157215646 @default.
• W2788889448 cites W2326024723 @default.
• W2788889448 cites W2554920072 @default.
• W2788889448 cites W4255042798 @default.
• W2788889448 doi "https://doi.org/10.1089/cbr.2017.2369" @default.
• W2788889448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29466034" @default.
• W2788889448 hasPublicationYear "2018" @default.
• W2788889448 type Work @default.
• W2788889448 sameAs 2788889448 @default.
• W2788889448 citedByCount "15" @default.
• W2788889448 countsByYear W27888894482018 @default.
• W2788889448 countsByYear W27888894482019 @default.
• W2788889448 countsByYear W27888894482020 @default.
• W2788889448 countsByYear W27888894482021 @default.
• W2788889448 countsByYear W27888894482022 @default.
• W2788889448 countsByYear W27888894482023 @default.
• W2788889448 crossrefType "journal-article" @default.
• W2788889448 hasAuthorship W2788889448A5013959664 @default.
• W2788889448 hasAuthorship W2788889448A5019120402 @default.
• W2788889448 hasAuthorship W2788889448A5021185518 @default.
• W2788889448 hasAuthorship W2788889448A5026061886 @default.
• W2788889448 hasAuthorship W2788889448A5028467654 @default.
• W2788889448 hasAuthorship W2788889448A5041799538 @default.
• W2788889448 hasAuthorship W2788889448A5046000864 @default.
• W2788889448 hasAuthorship W2788889448A5053216149 @default.
• W2788889448 hasAuthorship W2788889448A5065273787 @default.
• W2788889448 hasAuthorship W2788889448A5068851161 @default.
• W2788889448 hasAuthorship W2788889448A5089893665 @default.
• W2788889448 hasAuthorship W2788889448A5091198078 @default.
• W2788889448 hasConcept C126322002 @default.
• W2788889448 hasConcept C147483822 @default.
• W2788889448 hasConcept C147969180 @default.
• W2788889448 hasConcept C154317977 @default.
• W2788889448 hasConcept C167672396 @default.
• W2788889448 hasConcept C170493617 @default.
• W2788889448 hasConcept C202751555 @default.
• W2788889448 hasConcept C203014093 @default.
• W2788889448 hasConcept C2775960820 @default.
• W2788889448 hasConcept C2777587049 @default.
• W2788889448 hasConcept C2777863537 @default.
• W2788889448 hasConcept C2778939058 @default.
• W2788889448 hasConcept C2780394083 @default.
• W2788889448 hasConcept C502942594 @default.
• W2788889448 hasConcept C55493867 @default.
• W2788889448 hasConcept C71924100 @default.

• next