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• W2788892668 abstract "T cell activation requires the coordination of a variety of signaling molecules including T cell receptor-specific signals and costimulatory signals. Altering the composition and distribution of costimulatory molecules during stimulation greatly affects T cell functionality for applications such as adoptive cell therapy (ACT), but the large diversity in these molecules complicates these studies. Here, we develop and validate a reductionist T cell activation platform that enables streamlined customization of stimulatory conditions. This platform is useful for the optimization of ACT protocols as well as the more general study of immune T cell activation. Rather than decorating particles with both signal 1 antigen and signal 2 costimulus, we use distinct, monospecific, paramagnetic nanoparticles, which are then clustered on the cell surface by a magnetic field. This allows for rapid synthesis and characterization of a small number of single-signal nanoparticles which can be systematically combined to explore and optimize T cell activation. By increasing cognate T cell enrichment and incorporating additional costimulatory molecules using this platform, we find significantly higher frequencies and numbers of cognate T cells stimulated from an endogenous population. The magnetic field-induced association of separate particles thus provides a tool for optimizing T cell activation for adoptive immunotherapy and other immunological studies." @default.
• W2788892668 created "2018-03-06" @default.
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• W2788892668 creator A5061137097 @default.
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• W2788892668 date "2018-02-28" @default.
• W2788892668 modified "2023-10-10" @default.
• W2788892668 title "Separating T Cell Targeting Components onto Magnetically Clustered Nanoparticles Boosts Activation" @default.
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• W2788892668 doi "https://doi.org/10.1021/acs.nanolett.7b05284" @default.
• W2788892668 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6707078" @default.
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• W2788892668 hasPublicationYear "2018" @default.
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