FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2788893965> ?p ?o ?g. }

• W2788893965 endingPage "2880" @default.
• W2788893965 startingPage "2867" @default.
• W2788893965 abstract "Reversible self-association of therapeutic antibodies is a key factor in high protein solution viscosities. In the present work, a coarse-grained computational model accounting for electrostatic, dispersion, and long-ranged hydrodynamic interactions of two model monoclonal antibodies is applied to understand the nature of self-association, predicting the solution microstructure and resulting transport properties of the solution. For the proteins investigated, the structure factor across a range of solution conditions shows quantitative agreement with neutron-scattering experiments. We observe a homogeneous, dynamical association of the antibodies with no evidence of phase separation. Calculations of self-diffusivity and viscosity from coarse-grained dynamic simulations show the appropriate trends with concentration but, respectively, over- and under-predict the experimentally measured values. By adding constraints to the self-associated clusters that rigidify them under flow, prediction of the transport properties is significantly improved with respect to experimental measurements. We hypothesize that these rigidity constraints are associated with missing degrees of freedom in the coarse-grained model resulting from patchy and heterogeneous interactions among coarse-grained domains. These results demonstrate how structural anisotropy and anisotropy of interactions generated by features at the 2–5 nm length scale in antibodies are sufficient to recover the dynamics and rheological properties of these important macromolecular solutions." @default.
• W2788893965 created "2018-03-06" @default.
• W2788893965 creator A5004559776 @default.
• W2788893965 creator A5018596493 @default.
• W2788893965 creator A5026174852 @default.
• W2788893965 creator A5033652787 @default.
• W2788893965 creator A5056061382 @default.
• W2788893965 date "2018-02-22" @default.
• W2788893965 modified "2023-10-16" @default.
• W2788893965 title "Structure and Relaxation in Solutions of Monoclonal Antibodies" @default.
• W2788893965 cites W1709650666 @default.
• W2788893965 cites W1925483670 @default.
• W2788893965 cites W1970059431 @default.
• W2788893965 cites W1970166721 @default.
• W2788893965 cites W1980619521 @default.
• W2788893965 cites W1980705692 @default.
• W2788893965 cites W1984909504 @default.
• W2788893965 cites W1989925383 @default.
• W2788893965 cites W1992704537 @default.
• W2788893965 cites W1998336443 @default.
• W2788893965 cites W2007450029 @default.
• W2788893965 cites W2014954784 @default.
• W2788893965 cites W2022600257 @default.
• W2788893965 cites W2023269994 @default.
• W2788893965 cites W2026270306 @default.
• W2788893965 cites W2027248703 @default.
• W2788893965 cites W2028601571 @default.
• W2788893965 cites W2029667189 @default.
• W2788893965 cites W2030942238 @default.
• W2788893965 cites W2033723524 @default.
• W2788893965 cites W2033785641 @default.
• W2788893965 cites W2045332616 @default.
• W2788893965 cites W2048049691 @default.
• W2788893965 cites W2049816517 @default.
• W2788893965 cites W2051864856 @default.
• W2788893965 cites W2059050919 @default.
• W2788893965 cites W2059111274 @default.
• W2788893965 cites W2062214242 @default.
• W2788893965 cites W2064068263 @default.
• W2788893965 cites W2066294614 @default.
• W2788893965 cites W2069106252 @default.
• W2788893965 cites W2069988675 @default.
• W2788893965 cites W2071969518 @default.
• W2788893965 cites W2073911195 @default.
• W2788893965 cites W2076076242 @default.
• W2788893965 cites W2076100371 @default.
• W2788893965 cites W2076876086 @default.
• W2788893965 cites W2078391824 @default.
• W2788893965 cites W2078472083 @default.
• W2788893965 cites W2081888756 @default.
• W2788893965 cites W2096387523 @default.
• W2788893965 cites W2106334513 @default.
• W2788893965 cites W2107212848 @default.
• W2788893965 cites W2107403105 @default.
• W2788893965 cites W2110659779 @default.
• W2788893965 cites W2128485227 @default.
• W2788893965 cites W2142694980 @default.
• W2788893965 cites W2158035648 @default.
• W2788893965 cites W2159529419 @default.
• W2788893965 cites W2171695688 @default.
• W2788893965 cites W2233148062 @default.
• W2788893965 cites W2319569078 @default.
• W2788893965 cites W2320055325 @default.
• W2788893965 cites W2332113738 @default.
• W2788893965 cites W2333638978 @default.
• W2788893965 cites W2404486324 @default.
• W2788893965 cites W2411517854 @default.
• W2788893965 cites W2438904667 @default.
• W2788893965 cites W2491403440 @default.
• W2788893965 cites W2559124333 @default.
• W2788893965 cites W2744816153 @default.
• W2788893965 cites W4238520503 @default.
• W2788893965 doi "https://doi.org/10.1021/acs.jpcb.7b11053" @default.
• W2788893965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29469576" @default.
• W2788893965 hasPublicationYear "2018" @default.
• W2788893965 type Work @default.
• W2788893965 sameAs 2788893965 @default.
• W2788893965 citedByCount "34" @default.
• W2788893965 countsByYear W27888939652018 @default.
• W2788893965 countsByYear W27888939652019 @default.
• W2788893965 countsByYear W27888939652020 @default.
• W2788893965 countsByYear W27888939652021 @default.
• W2788893965 countsByYear W27888939652022 @default.
• W2788893965 countsByYear W27888939652023 @default.
• W2788893965 crossrefType "journal-article" @default.
• W2788893965 hasAuthorship W2788893965A5004559776 @default.
• W2788893965 hasAuthorship W2788893965A5018596493 @default.
• W2788893965 hasAuthorship W2788893965A5026174852 @default.
• W2788893965 hasAuthorship W2788893965A5033652787 @default.
• W2788893965 hasAuthorship W2788893965A5056061382 @default.
• W2788893965 hasConcept C104015590 @default.
• W2788893965 hasConcept C120665830 @default.
• W2788893965 hasConcept C121332964 @default.
• W2788893965 hasConcept C127172972 @default.
• W2788893965 hasConcept C15744967 @default.
• W2788893965 hasConcept C159467904 @default.
• W2788893965 hasConcept C185592680 @default.
• W2788893965 hasConcept C18762648 @default.

• next