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• W2788898240 endingPage "765" @default.
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• W2788898240 abstract "Effect-based methods including cell-based bioassays, reporter gene assays and whole-organism assays have been applied for decades in water quality monitoring and testing of enriched solid-phase extracts. There is no common EU-wide agreement on what level of bioassay response in water extracts is acceptable. At present, bioassay results are only benchmarked against each other but not against a consented measure of chemical water quality. The EU environmental quality standards (EQS) differentiate between acceptable and unacceptable surface water concentrations for individual chemicals but cannot capture the thousands of chemicals in water and their biological action as mixtures. We developed a method that reads across from existing EQS and includes additional mixture considerations with the goal that the derived effect-based trigger values (EBT) indicate acceptable risk for complex mixtures as they occur in surface water. Advantages and limitations of various approaches to read across from EQS are discussed and distilled to an algorithm that translates EQS into their corresponding bioanalytical equivalent concentrations (BEQ). The proposed EBT derivation method was applied to 48 in vitro bioassays with 32 of them having sufficient information to yield preliminary EBTs. To assess the practicability and robustness of the proposed approach, we compared the tentative EBTs with observed environmental effects. The proposed method only gives guidance on how to derive EBTs but does not propose final EBTs for implementation. The EBTs for some bioassays such as those for estrogenicity are already mature and could be implemented into regulation in the near future, while for others it will still take a few iterations until we can be confident of the power of the proposed EBTs to differentiate good from poor water quality with respect to chemical contamination." @default.
• W2788898240 created "2018-03-06" @default.
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• W2788898240 date "2018-07-01" @default.
• W2788898240 modified "2023-10-17" @default.
• W2788898240 title "Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive" @default.
• W2788898240 cites W107093596 @default.
• W2788898240 cites W1542953758 @default.
• W2788898240 cites W1958831354 @default.
• W2788898240 cites W1964644005 @default.
• W2788898240 cites W1967434540 @default.
• W2788898240 cites W1970355511 @default.
• W2788898240 cites W1972514204 @default.
• W2788898240 cites W1975275863 @default.
• W2788898240 cites W1976226148 @default.
• W2788898240 cites W1977146922 @default.
• W2788898240 cites W1979629637 @default.
• W2788898240 cites W1980913426 @default.
• W2788898240 cites W1990826530 @default.
• W2788898240 cites W1992944847 @default.
• W2788898240 cites W1993210636 @default.
• W2788898240 cites W1994701384 @default.
• W2788898240 cites W1995625202 @default.
• W2788898240 cites W1999312152 @default.
• W2788898240 cites W2000899261 @default.
• W2788898240 cites W2001052418 @default.
• W2788898240 cites W2003070275 @default.
• W2788898240 cites W2005706041 @default.
• W2788898240 cites W2006833903 @default.
• W2788898240 cites W2014622549 @default.
• W2788898240 cites W2014855149 @default.
• W2788898240 cites W2017933502 @default.
• W2788898240 cites W2020669755 @default.
• W2788898240 cites W2020970672 @default.
• W2788898240 cites W2025533533 @default.
• W2788898240 cites W2027575018 @default.
• W2788898240 cites W2028861891 @default.
• W2788898240 cites W2029591801 @default.
• W2788898240 cites W2037760751 @default.
• W2788898240 cites W2039023381 @default.
• W2788898240 cites W2039754709 @default.
• W2788898240 cites W2045926646 @default.
• W2788898240 cites W2054229424 @default.
• W2788898240 cites W2065242456 @default.
• W2788898240 cites W2067897981 @default.
• W2788898240 cites W2070291526 @default.
• W2788898240 cites W2071113470 @default.
• W2788898240 cites W2078271371 @default.
• W2788898240 cites W2095394277 @default.
• W2788898240 cites W2095718513 @default.
• W2788898240 cites W2100229416 @default.
• W2788898240 cites W2101923271 @default.
• W2788898240 cites W2106970827 @default.
• W2788898240 cites W2107866850 @default.
• W2788898240 cites W2112425978 @default.
• W2788898240 cites W2115404169 @default.
• W2788898240 cites W2116515997 @default.
• W2788898240 cites W2117465766 @default.
• W2788898240 cites W2119745101 @default.
• W2788898240 cites W2120798598 @default.
• W2788898240 cites W2124113020 @default.
• W2788898240 cites W2132024398 @default.
• W2788898240 cites W2133615159 @default.
• W2788898240 cites W2141792300 @default.
• W2788898240 cites W2142815439 @default.
• W2788898240 cites W2149189609 @default.
• W2788898240 cites W2151494136 @default.
• W2788898240 cites W2153479003 @default.
• W2788898240 cites W2154341508 @default.
• W2788898240 cites W2155423098 @default.
• W2788898240 cites W2161286968 @default.
• W2788898240 cites W2163072832 @default.
• W2788898240 cites W2163762886 @default.
• W2788898240 cites W2164322685 @default.
• W2788898240 cites W2164610579 @default.
• W2788898240 cites W2168242147 @default.
• W2788898240 cites W2169900825 @default.
• W2788898240 cites W2232950086 @default.
• W2788898240 cites W2325524586 @default.

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