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- W2788943938 abstract "BackgroundStem cell based intervertebral disc (IVD) regeneration is quickly moving towards clinical applications. However, many aspects need to be investigated to routinely translate this therapy to clinical applications, in particular, the most efficient way to deliver cell to the IVD. Cells are commonly delivered to the IVD through the annulus fibrosus (AF) injection. However, recent studies have shown serious drawbacks of this approach. As an alternative we have described and tested a new surgical approach to the IVD via the endplate-pedicles (transpedicular approach). The Purpose of the study was to test MSCs/hydrogel transplantation for IVD regeneration in a grade IV preclinical model of IDD on large size animals via the transpeducular approach with cell dose escalation.MethodsAdult sheep (n=18) underwent bone marrow aspiration for autologous MSC isolation and expansion. MSC were suspended in autologous PRP and conjugated with Hyaluronic Acid and Batroxobin at the time of transplant (MSCs/hydrogel). ..." @default.
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- W2788943938 date "2018-02-21" @default.
- W2788943938 modified "2023-10-08" @default.
- W2788943938 title "DISC REGENERATION USING MSC TRANSPLANTED VIA THE ENDPLATE ROUTE" @default.
- W2788943938 hasPublicationYear "2018" @default.
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