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- W2789013284 endingPage "753" @default.
- W2789013284 startingPage "717" @default.
- W2789013284 abstract "Antigen cross-presentation is an adaptation of the cellular process of loading MHC-I molecules with endogenous peptides during their biosynthesis within the endoplasmic reticulum. Cross-presented peptides derive from internalized proteins, microbial pathogens, and transformed or dying cells. The physical separation of internalized cargo from the endoplasmic reticulum, where the machinery for assembling peptide–MHC-I complexes resides, poses a challenge. To solve this problem, deliberate rewiring of organelle communication within cells is necessary to prepare for cross-presentation, and different endocytic receptors and vesicular traffic patterns customize the emergent cross-presentation compartment to the nature of the peptide source. Three distinct pathways of vesicular traffic converge to form the ideal cross-presentation compartment, each regulated differently to supply a unique component that enables cross-presentation of a diverse repertoire of peptides. Delivery of centerpiece MHC-I molecules is the critical step regulated by microbe-sensitive Toll-like receptors. Defining the subcellular sources of MHC-I and identifying sites of peptide loading during cross-presentation remain key challenges." @default.
- W2789013284 created "2018-03-06" @default.
- W2789013284 creator A5021137278 @default.
- W2789013284 date "2018-04-26" @default.
- W2789013284 modified "2023-10-17" @default.
- W2789013284 title "Regulation of the Cell Biology of Antigen Cross-Presentation" @default.
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