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- W2789185087 abstract "Injury to the adult central nervous systems (CNS) can result in severe long-term disability because damaged CNS connections fail to regenerate after trauma. Identification of regulators that enhance the intrinsic growth capacity of severed axons is a first step to restore function. Here, we conducted a gain of function genetic screen in Drosophila to identify strong inducers of axonal growth after injury. We focus on a novel axis the Down Syndrome Cell Adhesion Molecule (Dscam1), the de-ubiquitinating enzyme Fat Facets (Faf)/Usp9x and the Jun N-Terminal Kinase (JNK) pathway transcription factor Kayak (Kay)/Fos. Genetic and biochemical analyses link these genes in a common signaling pathway whereby Faf stabilizes Dscam1 protein levels, by acting on the 3’-UTR of its mRNA, and Dscam1 acts upstream of the growth-promoting JNK signal. The mammalian homolog of Faf, Usp9x/FAM, shares both the regenerative and Dscam1 stabilizing activities, suggesting a conserved mechanism." @default.
- W2789185087 created "2018-03-06" @default.
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- W2789185087 date "2018-02-08" @default.
- W2789185087 modified "2023-10-17" @default.
- W2789185087 title "A Fat-Facets-Dscam1-JNK Pathway Enhances Axonal Growth in Development and after Injury" @default.
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- W2789185087 doi "https://doi.org/10.3389/fncel.2017.00416" @default.
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