Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789243233> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2789243233 abstract "Objective: The objective of the present study was to synthesize a series of 3-hydroxychromone derivatives and to evaluate its in vitro antioxidant and antimicrobial activities.Methods: 3-hydroxy chromones were synthesized using an algar flynn oyamada method which includes oxidative cyclization of 2-hydroxy chalcones in basic solution by hydrogen peroxide. 2-hydroxy chalcones were synthesized by Claisen-Schmidt condensation of substituted 2-hydroxy acetophenones with substituted aromatic aldehydes using polyethylene glycol-400 as a recyclable solvent. The synthesized compounds were evaluated for in vitro antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. In addition, these compounds were also screened for in vitro antibacterial and antifungal activity by agar cup method and Poison plate method, respectively.Results: The structures of the synthesized compounds were characterized by infrared, 1H nuclear magnetic resonance and mass spectroscopy. The antioxidant activity data revealed that all the synthesized derivatives exhibited good activity due to the presence of phenolic hydroxyl group, 4-oxo group and 2,3-double bond. Further, the activity increased with the introduction of a more phenolic hydroxyl group and adjacent methoxy group in the structure. The antimicrobial activity data showed that the compounds possess better antibacterial and antifungal activity which is attributed to the presence of phenolic hydroxyl group and 4-oxo group in the structure.Conclusions: The use of inexpensive, eco-friendly and readily available reagents, easy work-up and high purity of products makes the procedure a convenient and robust method for the synthesis of title compounds. The presence of phenolic hydroxyl group, 4-oxo group, and 2,3-double bond in the structure is responsible for their good antioxidant and antimicrobial activities." @default.
- W2789243233 created "2018-03-29" @default.
- W2789243233 creator A5040546235 @default.
- W2789243233 creator A5073626472 @default.
- W2789243233 date "2018-03-01" @default.
- W2789243233 modified "2023-10-18" @default.
- W2789243233 title "SYNTHESIS, IN VITRO ANTIOXIDANT AND ANTIMICROBIAL EVALUATION OF 3-HYDROXY CHROMONE DERIVATIVES" @default.
- W2789243233 cites W1913312352 @default.
- W2789243233 cites W1959555296 @default.
- W2789243233 cites W2003382315 @default.
- W2789243233 cites W2027977588 @default.
- W2789243233 cites W2049648149 @default.
- W2789243233 cites W2053736404 @default.
- W2789243233 cites W2055566993 @default.
- W2789243233 cites W2062929884 @default.
- W2789243233 cites W2086959952 @default.
- W2789243233 cites W2174426522 @default.
- W2789243233 cites W2333398755 @default.
- W2789243233 doi "https://doi.org/10.22159/ajpcr.2018.v11i3.22984" @default.
- W2789243233 hasPublicationYear "2018" @default.
- W2789243233 type Work @default.
- W2789243233 sameAs 2789243233 @default.
- W2789243233 citedByCount "1" @default.
- W2789243233 countsByYear W27892432332020 @default.
- W2789243233 crossrefType "journal-article" @default.
- W2789243233 hasAuthorship W2789243233A5040546235 @default.
- W2789243233 hasAuthorship W2789243233A5073626472 @default.
- W2789243233 hasBestOaLocation W27892432331 @default.
- W2789243233 hasConcept C13965031 @default.
- W2789243233 hasConcept C178790620 @default.
- W2789243233 hasConcept C185592680 @default.
- W2789243233 hasConcept C2776778087 @default.
- W2789243233 hasConcept C2778004101 @default.
- W2789243233 hasConcept C2780104969 @default.
- W2789243233 hasConcept C40875361 @default.
- W2789243233 hasConcept C4937899 @default.
- W2789243233 hasConcept C523546767 @default.
- W2789243233 hasConcept C533411734 @default.
- W2789243233 hasConcept C54355233 @default.
- W2789243233 hasConcept C86803240 @default.
- W2789243233 hasConceptScore W2789243233C13965031 @default.
- W2789243233 hasConceptScore W2789243233C178790620 @default.
- W2789243233 hasConceptScore W2789243233C185592680 @default.
- W2789243233 hasConceptScore W2789243233C2776778087 @default.
- W2789243233 hasConceptScore W2789243233C2778004101 @default.
- W2789243233 hasConceptScore W2789243233C2780104969 @default.
- W2789243233 hasConceptScore W2789243233C40875361 @default.
- W2789243233 hasConceptScore W2789243233C4937899 @default.
- W2789243233 hasConceptScore W2789243233C523546767 @default.
- W2789243233 hasConceptScore W2789243233C533411734 @default.
- W2789243233 hasConceptScore W2789243233C54355233 @default.
- W2789243233 hasConceptScore W2789243233C86803240 @default.
- W2789243233 hasLocation W27892432331 @default.
- W2789243233 hasOpenAccess W2789243233 @default.
- W2789243233 hasPrimaryLocation W27892432331 @default.
- W2789243233 hasRelatedWork W1552724895 @default.
- W2789243233 hasRelatedWork W1972977500 @default.
- W2789243233 hasRelatedWork W1977767449 @default.
- W2789243233 hasRelatedWork W1979111967 @default.
- W2789243233 hasRelatedWork W2012292853 @default.
- W2789243233 hasRelatedWork W2018464010 @default.
- W2789243233 hasRelatedWork W2086975895 @default.
- W2789243233 hasRelatedWork W2183620619 @default.
- W2789243233 hasRelatedWork W22831626 @default.
- W2789243233 hasRelatedWork W2396510421 @default.
- W2789243233 hasRelatedWork W2529441220 @default.
- W2789243233 hasRelatedWork W2766491161 @default.
- W2789243233 hasRelatedWork W2781606118 @default.
- W2789243233 hasRelatedWork W2951180432 @default.
- W2789243233 hasRelatedWork W2996971148 @default.
- W2789243233 hasRelatedWork W3009297267 @default.
- W2789243233 hasRelatedWork W3010689252 @default.
- W2789243233 hasRelatedWork W2187743097 @default.
- W2789243233 hasRelatedWork W3005259815 @default.
- W2789243233 hasRelatedWork W3129005075 @default.
- W2789243233 isParatext "false" @default.
- W2789243233 isRetracted "false" @default.
- W2789243233 magId "2789243233" @default.
- W2789243233 workType "article" @default.