FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789284989> ?p ?o ?g. }

• W2789284989 endingPage "737" @default.
• W2789284989 startingPage "728" @default.
• W2789284989 abstract "Pancreatic ductal adenocarcinoma (PDAC) has poor prognosis and high mortality rate. Inhibitor of differentiation-1 (ID-1) overexpression has already been reported to be associated with low survival, but the detailed roles of ID-1 in PDAC are unclear. As an ID-1 inhibitor, 2-methoxyestradiol (2-ME) has been shown effective in the antitumor therapies, but its effect on PDAC is unknown. In this study, ID-1 overexpression and knockdown stable SW1990 cells were used to examine proliferation, migration and invasion abilities. Effectiveness of 2-ME was estimated in vivo, as well as in vitro by survival analysis, magnetic resonance imaging and tissue analysis. PDAC patients were retrospectively reviewed to assess the ID-1 expression and prognosis. We found that ID-1 was closely associated with in vitro SW1990 cells proliferation, migration and invasion abilities, as well as the expression of HIF-1α, VEGF and MMP-9. 2-ME was shown to be effective on tumor suppression both in vivo and in vitro, perhaps mainly by ID-1 regulation. Moreover, the relevance between high ID-1 expression and poor prognosis was validated in PDAC patients. Our data collectively reveals the roles of ID-1 in PDAC malignancy, and suggests 2-ME treatment may be a potential alternative chemotherapeutic agent for PDAC patients." @default.
• W2789284989 created "2018-03-29" @default.
• W2789284989 creator A5015544352 @default.
• W2789284989 creator A5023024547 @default.
• W2789284989 creator A5024145264 @default.
• W2789284989 creator A5029634246 @default.
• W2789284989 creator A5041657955 @default.
• W2789284989 creator A5064352033 @default.
• W2789284989 creator A5071314403 @default.
• W2789284989 creator A5082964883 @default.
• W2789284989 date "2018-03-16" @default.
• W2789284989 modified "2023-10-14" @default.
• W2789284989 title "The roles of ID-1 in human pancreatic ductal adenocarcinoma and the therapeutic effects of 2-methoxyestradiol" @default.
• W2789284989 cites W1971166256 @default.
• W2789284989 cites W1976284083 @default.
• W2789284989 cites W1977321706 @default.
• W2789284989 cites W1983536190 @default.
• W2789284989 cites W1983964043 @default.
• W2789284989 cites W1985670392 @default.
• W2789284989 cites W2003292783 @default.
• W2789284989 cites W2049954943 @default.
• W2789284989 cites W2057216898 @default.
• W2789284989 cites W2075319732 @default.
• W2789284989 cites W2096291986 @default.
• W2789284989 cites W2115609800 @default.
• W2789284989 cites W2115658806 @default.
• W2789284989 cites W2125164793 @default.
• W2789284989 cites W2139149338 @default.
• W2789284989 cites W2142313327 @default.
• W2789284989 cites W2156597720 @default.
• W2789284989 cites W2157689179 @default.
• W2789284989 cites W2166435019 @default.
• W2789284989 cites W2166601591 @default.
• W2789284989 cites W2191828272 @default.
• W2789284989 cites W3134530972 @default.
• W2789284989 cites W3144138202 @default.
• W2789284989 doi "https://doi.org/10.1093/carcin/bgy035" @default.
• W2789284989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29566125" @default.
• W2789284989 hasPublicationYear "2018" @default.
• W2789284989 type Work @default.
• W2789284989 sameAs 2789284989 @default.
• W2789284989 citedByCount "4" @default.
• W2789284989 countsByYear W27892849892020 @default.
• W2789284989 countsByYear W27892849892021 @default.
• W2789284989 countsByYear W27892849892022 @default.
• W2789284989 countsByYear W27892849892023 @default.
• W2789284989 crossrefType "journal-article" @default.
• W2789284989 hasAuthorship W2789284989A5015544352 @default.
• W2789284989 hasAuthorship W2789284989A5023024547 @default.
• W2789284989 hasAuthorship W2789284989A5024145264 @default.
• W2789284989 hasAuthorship W2789284989A5029634246 @default.
• W2789284989 hasAuthorship W2789284989A5041657955 @default.
• W2789284989 hasAuthorship W2789284989A5064352033 @default.
• W2789284989 hasAuthorship W2789284989A5071314403 @default.
• W2789284989 hasAuthorship W2789284989A5082964883 @default.
• W2789284989 hasBestOaLocation W27892849891 @default.
• W2789284989 hasConcept C121608353 @default.
• W2789284989 hasConcept C126322002 @default.
• W2789284989 hasConcept C150903083 @default.
• W2789284989 hasConcept C173396325 @default.
• W2789284989 hasConcept C190283241 @default.
• W2789284989 hasConcept C202751555 @default.
• W2789284989 hasConcept C207001950 @default.
• W2789284989 hasConcept C2776260442 @default.
• W2789284989 hasConcept C2779399171 @default.
• W2789284989 hasConcept C2780210213 @default.
• W2789284989 hasConcept C2781182431 @default.
• W2789284989 hasConcept C502942594 @default.
• W2789284989 hasConcept C55493867 @default.
• W2789284989 hasConcept C71924100 @default.
• W2789284989 hasConcept C86803240 @default.
• W2789284989 hasConceptScore W2789284989C121608353 @default.
• W2789284989 hasConceptScore W2789284989C126322002 @default.
• W2789284989 hasConceptScore W2789284989C150903083 @default.
• W2789284989 hasConceptScore W2789284989C173396325 @default.
• W2789284989 hasConceptScore W2789284989C190283241 @default.
• W2789284989 hasConceptScore W2789284989C202751555 @default.
• W2789284989 hasConceptScore W2789284989C207001950 @default.
• W2789284989 hasConceptScore W2789284989C2776260442 @default.
• W2789284989 hasConceptScore W2789284989C2779399171 @default.
• W2789284989 hasConceptScore W2789284989C2780210213 @default.
• W2789284989 hasConceptScore W2789284989C2781182431 @default.
• W2789284989 hasConceptScore W2789284989C502942594 @default.
• W2789284989 hasConceptScore W2789284989C55493867 @default.
• W2789284989 hasConceptScore W2789284989C71924100 @default.
• W2789284989 hasConceptScore W2789284989C86803240 @default.
• W2789284989 hasFunder F4320321001 @default.
• W2789284989 hasIssue "5" @default.
• W2789284989 hasLocation W27892849891 @default.
• W2789284989 hasLocation W27892849892 @default.
• W2789284989 hasOpenAccess W2789284989 @default.
• W2789284989 hasPrimaryLocation W27892849891 @default.
• W2789284989 hasRelatedWork W1130411065 @default.
• W2789284989 hasRelatedWork W2031996587 @default.
• W2789284989 hasRelatedWork W2043890160 @default.
• W2789284989 hasRelatedWork W2050306700 @default.
• W2789284989 hasRelatedWork W2062989326 @default.
• W2789284989 hasRelatedWork W2080089609 @default.

• next