FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789286023> ?p ?o ?g. }

• W2789286023 endingPage "94" @default.
• W2789286023 startingPage "86" @default.
• W2789286023 abstract "Metastatic invasion is the primary cause of treatment failure for GBM. EMT is one of the most important events in the invasion of GBM; therefore, understanding the molecular mechanisms of EMT is crucial for the treatment of GBM. In this study, high expression of DRR1 was identified to correlate with a shorter median overall and relapse-free survival. Loss-of-function assays using shDRR1 weakened the invasive potential of the GBM cell lines through regulation of EMT-markers. The expressions of p-AKT were significantly decreased after DRR-depletion in SHG44 and U373 cells. Moreover, the invasion was inhibited by the AKT inhibitor, MK-2206. The expression of Vimentin, N-cadherin, MMP-7, snail and slug was significantly inhibited by MK-2206, while the expression of E-cadherin was upregulated. Our results provide the first evidence that DRR1 is involved in GBM invasion and progression possibly through the induction of EMT activation by phosphorylation of AKT." @default.
• W2789286023 created "2018-03-29" @default.
• W2789286023 creator A5000029097 @default.
• W2789286023 creator A5000437101 @default.
• W2789286023 creator A5003685943 @default.
• W2789286023 creator A5007405399 @default.
• W2789286023 creator A5014828679 @default.
• W2789286023 creator A5020227451 @default.
• W2789286023 creator A5020501900 @default.
• W2789286023 creator A5035163215 @default.
• W2789286023 creator A5049863390 @default.
• W2789286023 creator A5050200141 @default.
• W2789286023 creator A5051200107 @default.
• W2789286023 creator A5056459929 @default.
• W2789286023 creator A5058266405 @default.
• W2789286023 creator A5060107207 @default.
• W2789286023 creator A5066431972 @default.
• W2789286023 creator A5072024057 @default.
• W2789286023 creator A5091070290 @default.
• W2789286023 date "2018-06-01" @default.
• W2789286023 modified "2023-10-15" @default.
• W2789286023 title "DRR1 promotes glioblastoma cell invasion and epithelial-mesenchymal transition via regulating AKT activation" @default.
• W2789286023 cites W1965627911 @default.
• W2789286023 cites W1967988059 @default.
• W2789286023 cites W1973890143 @default.
• W2789286023 cites W1979988883 @default.
• W2789286023 cites W1980832859 @default.
• W2789286023 cites W1982565766 @default.
• W2789286023 cites W1985345335 @default.
• W2789286023 cites W1996464919 @default.
• W2789286023 cites W2018949149 @default.
• W2789286023 cites W2024783096 @default.
• W2789286023 cites W2028589731 @default.
• W2789286023 cites W2048284928 @default.
• W2789286023 cites W2055207697 @default.
• W2789286023 cites W2066419333 @default.
• W2789286023 cites W2077046830 @default.
• W2789286023 cites W2089716651 @default.
• W2789286023 cites W2093238681 @default.
• W2789286023 cites W2096334202 @default.
• W2789286023 cites W2107277218 @default.
• W2789286023 cites W2110707947 @default.
• W2789286023 cites W2120942362 @default.
• W2789286023 cites W2265166065 @default.
• W2789286023 cites W2280923709 @default.
• W2789286023 cites W2425341021 @default.
• W2789286023 cites W2486379543 @default.
• W2789286023 cites W2494824067 @default.
• W2789286023 cites W2529946249 @default.
• W2789286023 cites W2560936010 @default.
• W2789286023 cites W2565304789 @default.
• W2789286023 cites W2572807235 @default.
• W2789286023 cites W2584623480 @default.
• W2789286023 cites W2585659713 @default.
• W2789286023 cites W2587975625 @default.
• W2789286023 cites W2610739723 @default.
• W2789286023 cites W2613006951 @default.
• W2789286023 cites W2615770054 @default.
• W2789286023 cites W2625661604 @default.
• W2789286023 cites W2725765951 @default.
• W2789286023 cites W2746222363 @default.
• W2789286023 cites W2748399758 @default.
• W2789286023 cites W2753261645 @default.
• W2789286023 cites W2765957994 @default.
• W2789286023 doi "https://doi.org/10.1016/j.canlet.2018.03.015" @default.
• W2789286023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29548818" @default.
• W2789286023 hasPublicationYear "2018" @default.
• W2789286023 type Work @default.
• W2789286023 sameAs 2789286023 @default.
• W2789286023 citedByCount "25" @default.
• W2789286023 countsByYear W27892860232018 @default.
• W2789286023 countsByYear W27892860232019 @default.
• W2789286023 countsByYear W27892860232020 @default.
• W2789286023 countsByYear W27892860232021 @default.
• W2789286023 countsByYear W27892860232022 @default.
• W2789286023 countsByYear W27892860232023 @default.
• W2789286023 crossrefType "journal-article" @default.
• W2789286023 hasAuthorship W2789286023A5000029097 @default.
• W2789286023 hasAuthorship W2789286023A5000437101 @default.
• W2789286023 hasAuthorship W2789286023A5003685943 @default.
• W2789286023 hasAuthorship W2789286023A5007405399 @default.
• W2789286023 hasAuthorship W2789286023A5014828679 @default.
• W2789286023 hasAuthorship W2789286023A5020227451 @default.
• W2789286023 hasAuthorship W2789286023A5020501900 @default.
• W2789286023 hasAuthorship W2789286023A5035163215 @default.
• W2789286023 hasAuthorship W2789286023A5049863390 @default.
• W2789286023 hasAuthorship W2789286023A5050200141 @default.
• W2789286023 hasAuthorship W2789286023A5051200107 @default.
• W2789286023 hasAuthorship W2789286023A5056459929 @default.
• W2789286023 hasAuthorship W2789286023A5058266405 @default.
• W2789286023 hasAuthorship W2789286023A5060107207 @default.
• W2789286023 hasAuthorship W2789286023A5066431972 @default.
• W2789286023 hasAuthorship W2789286023A5072024057 @default.
• W2789286023 hasAuthorship W2789286023A5091070290 @default.
• W2789286023 hasConcept C104317684 @default.
• W2789286023 hasConcept C11960822 @default.
• W2789286023 hasConcept C127561419 @default.
• W2789286023 hasConcept C147447768 @default.

• next