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- W2789288773 abstract "Filifactor alocis is a newly appreciated pathogen in periodontal diseases. Neutrophils are the predominant innate immune cell in the gingival crevice. In this study, we examined modulation of human neutrophil antimicrobial functions by F. alocis. Both non-opsonised and serum-opsonised F. alocis were engulfed by neutrophils but were not efficiently eliminated. Challenge of neutrophils with either non-opsonised or serum-opsonised F. alocis induced a minimal intracellular as well as extracellular respiratory burst response compared to opsonised Staphylococcus aureus and fMLF, respectively. However, pretreatment or simultaneous challenge of neutrophils with F. alocis did not affect the subsequent oxidative response to a particulate stimulus, suggesting that the inability to trigger the respiratory response was only localised to F. alocis phagosomes. In addition, although neutrophils engulfed live or heat-killed F. alocis with the same efficiency, heat-killed F. alocis elicited a higher intracellular respiratory burst response compared to viable organisms, along with decreased surface expression of CD35, a marker of secretory vesicles. F. alocis phagosomes remained immature by delayed and reduced recruitment of specific and azurophil granules, respectively. These results suggest that F. alocis withstands neutrophil antimicrobial responses by preventing intracellular ROS production, along with specific and azurophil granule recruitment to the bacterial phagosome." @default.
- W2789288773 created "2018-03-29" @default.
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- W2789288773 date "2018-02-12" @default.
- W2789288773 modified "2023-10-16" @default.
- W2789288773 title "<i>Filifactor alocis</i> modulates human neutrophil antimicrobial functional responses" @default.
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- W2789288773 doi "https://doi.org/10.1111/cmi.12829" @default.
- W2789288773 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5980721" @default.
- W2789288773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29377528" @default.
- W2789288773 hasPublicationYear "2018" @default.
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