Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789325794> ?p ?o ?g. }
- W2789325794 abstract "Glycan metabolism balance is critical for cell prosperity, and macromolecule glycosylation is essential for cell communication, signaling and survival. Thus, glycotherapy may be a potential cancer treatment. The aim of the present study was to determine whether combined synthetic glycoconjugates (GCs) induce changes in gene expression that alter the survival of colon cancer cells. The current study evaluated the effect of the GCs N‑acetyl‑D‑glucosamine modified polyamidoamine dendrimer and calix[4]arene scaffold on cancer cell proliferation, apoptosis, invasion and sensitivity to immune cell‑mediated killing. Using reverse transcription‑quantitative polymerase chain reaction, the expression of genes involved in the aforementioned processes was measured. It was determined that GCs reduce the expression of the glucosaminyltransferases Mgat3 and Mgat5 responsible for surface glycosylation and employed components of the Wnt signaling pathway Wnt2B and Wnt9B. In addition, the calix[4]arene‑based GC reduced cell colony formation; this was accompanied by the downregulation of the metalloproteinase Mmp3. By contrast, the dendrimer‑based GC affected the expression of the glucose transporter components Sglt1 and Egfr1. Therefore, to the best of our knowledge, the present study is the first to reveal that N‑acetyl‑D‑glucosamine‑dendrimer/calix[4]arene GCs alter mRNA expression in a comprehensive way, resulting in the reduced malignant phenotype of the colon cancer cell line HT‑29." @default.
- W2789325794 created "2018-03-29" @default.
- W2789325794 creator A5000122541 @default.
- W2789325794 creator A5001093236 @default.
- W2789325794 creator A5004424802 @default.
- W2789325794 creator A5025708845 @default.
- W2789325794 creator A5059071409 @default.
- W2789325794 date "2018-01-25" @default.
- W2789325794 modified "2023-10-18" @default.
- W2789325794 title "Interaction of colon cancer cells with glycoconjugates triggers complex changes in gene expression, glucose transporters and cell invasion" @default.
- W2789325794 cites W1182461782 @default.
- W2789325794 cites W189173739 @default.
- W2789325794 cites W1900608493 @default.
- W2789325794 cites W1914585871 @default.
- W2789325794 cites W1936264629 @default.
- W2789325794 cites W1942563879 @default.
- W2789325794 cites W1963858437 @default.
- W2789325794 cites W1968044382 @default.
- W2789325794 cites W1969135955 @default.
- W2789325794 cites W1972001907 @default.
- W2789325794 cites W1973079716 @default.
- W2789325794 cites W1975099453 @default.
- W2789325794 cites W1975694462 @default.
- W2789325794 cites W1981336564 @default.
- W2789325794 cites W1982972434 @default.
- W2789325794 cites W1984513282 @default.
- W2789325794 cites W1990867354 @default.
- W2789325794 cites W1992830540 @default.
- W2789325794 cites W1993597798 @default.
- W2789325794 cites W1995045174 @default.
- W2789325794 cites W1995691857 @default.
- W2789325794 cites W2000653700 @default.
- W2789325794 cites W2000948510 @default.
- W2789325794 cites W2000973093 @default.
- W2789325794 cites W2004468585 @default.
- W2789325794 cites W2007928677 @default.
- W2789325794 cites W2009657056 @default.
- W2789325794 cites W2012508528 @default.
- W2789325794 cites W2013470723 @default.
- W2789325794 cites W2024101412 @default.
- W2789325794 cites W2025932873 @default.
- W2789325794 cites W2045959839 @default.
- W2789325794 cites W2046775283 @default.
- W2789325794 cites W2047925389 @default.
- W2789325794 cites W2049439182 @default.
- W2789325794 cites W2058222111 @default.
- W2789325794 cites W2064919290 @default.
- W2789325794 cites W2067868815 @default.
- W2789325794 cites W2072952339 @default.
- W2789325794 cites W2073418997 @default.
- W2789325794 cites W2078752434 @default.
- W2789325794 cites W2085128560 @default.
- W2789325794 cites W2092038973 @default.
- W2789325794 cites W2092581013 @default.
- W2789325794 cites W2094882473 @default.
- W2789325794 cites W2097562777 @default.
- W2789325794 cites W2097704007 @default.
- W2789325794 cites W2107277218 @default.
- W2789325794 cites W2117692326 @default.
- W2789325794 cites W2124488542 @default.
- W2789325794 cites W2131043644 @default.
- W2789325794 cites W2132321056 @default.
- W2789325794 cites W2133469996 @default.
- W2789325794 cites W2138900092 @default.
- W2789325794 cites W2141228342 @default.
- W2789325794 cites W2141334650 @default.
- W2789325794 cites W2143600397 @default.
- W2789325794 cites W2145603619 @default.
- W2789325794 cites W2156723868 @default.
- W2789325794 cites W2158633610 @default.
- W2789325794 cites W2160700295 @default.
- W2789325794 cites W2167979700 @default.
- W2789325794 cites W2171544336 @default.
- W2789325794 cites W2190652017 @default.
- W2789325794 cites W2320453739 @default.
- W2789325794 cites W2321503226 @default.
- W2789325794 cites W2323806168 @default.
- W2789325794 cites W2338872484 @default.
- W2789325794 cites W2339541037 @default.
- W2789325794 cites W2397703541 @default.
- W2789325794 cites W2482784592 @default.
- W2789325794 cites W2508910949 @default.
- W2789325794 cites W2737587224 @default.
- W2789325794 cites W2755033919 @default.
- W2789325794 cites W2755173661 @default.
- W2789325794 cites W2766768871 @default.
- W2789325794 cites W4241900369 @default.
- W2789325794 doi "https://doi.org/10.3892/mmr.2018.8490" @default.
- W2789325794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29393416" @default.
- W2789325794 hasPublicationYear "2018" @default.
- W2789325794 type Work @default.
- W2789325794 sameAs 2789325794 @default.
- W2789325794 citedByCount "2" @default.
- W2789325794 countsByYear W27893257942020 @default.
- W2789325794 countsByYear W27893257942022 @default.
- W2789325794 crossrefType "journal-article" @default.
- W2789325794 hasAuthorship W2789325794A5000122541 @default.
- W2789325794 hasAuthorship W2789325794A5001093236 @default.
- W2789325794 hasAuthorship W2789325794A5004424802 @default.
- W2789325794 hasAuthorship W2789325794A5025708845 @default.