Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789326366> ?p ?o ?g. }
- W2789326366 endingPage "1537" @default.
- W2789326366 startingPage "1523" @default.
- W2789326366 abstract "LSD1/KDM1 is a histone demethylase that preferentially removes methyl groups from the mono- and di-methylated lysine 4 in histone H3 (H3K4), key marks for active chromatin for transcriptional activation. LSD1 is essential for pluripotent embryonic stem cells and embryonic teratocarcinoma/carcinoma cells and its expression is often elevated in various cancers. We developed a new LSD1 inhibitor, CBB3001, which potently inhibited LSD1 activity both in vitro and in vivo. CBB3001 also selectively inhibited the growth of human ovarian teratocarcinoma PA-1 and mouse embryonic carcinoma F9 cells, caused the downregulation of pluripotent stem cell proteins SOX2 and OCT4. However, CBB3001 does not have significant inhibition on the growth of human colorectal carcinoma HCT116 cells or mouse fibroblast NIH3T3 cells that do not express these stem cell proteins. Our studies strongly indicate that CBB3001 is a specific LSD1 inhibitor that selectively inhibits teratocarcinoma and embryonic carcinoma cells that express SOX2 and OCT4." @default.
- W2789326366 created "2018-03-29" @default.
- W2789326366 creator A5003759585 @default.
- W2789326366 creator A5016622484 @default.
- W2789326366 creator A5022439109 @default.
- W2789326366 creator A5028807063 @default.
- W2789326366 creator A5036796481 @default.
- W2789326366 creator A5046327468 @default.
- W2789326366 creator A5053663279 @default.
- W2789326366 creator A5058794772 @default.
- W2789326366 creator A5060785468 @default.
- W2789326366 creator A5087766294 @default.
- W2789326366 creator A5090708858 @default.
- W2789326366 date "2018-05-01" @default.
- W2789326366 modified "2023-10-16" @default.
- W2789326366 title "New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells" @default.
- W2789326366 cites W1603797292 @default.
- W2789326366 cites W1964813856 @default.
- W2789326366 cites W1965784662 @default.
- W2789326366 cites W1971561248 @default.
- W2789326366 cites W1972006421 @default.
- W2789326366 cites W1974820106 @default.
- W2789326366 cites W1978820716 @default.
- W2789326366 cites W1982116347 @default.
- W2789326366 cites W1983532163 @default.
- W2789326366 cites W1996358062 @default.
- W2789326366 cites W2005253752 @default.
- W2789326366 cites W2013785611 @default.
- W2789326366 cites W2016789999 @default.
- W2789326366 cites W2019571529 @default.
- W2789326366 cites W2021541624 @default.
- W2789326366 cites W2028720004 @default.
- W2789326366 cites W2029462077 @default.
- W2789326366 cites W2034084795 @default.
- W2789326366 cites W2034156554 @default.
- W2789326366 cites W2037817306 @default.
- W2789326366 cites W2040365233 @default.
- W2789326366 cites W2040365591 @default.
- W2789326366 cites W2049868369 @default.
- W2789326366 cites W2054358967 @default.
- W2789326366 cites W2063333928 @default.
- W2789326366 cites W2063982921 @default.
- W2789326366 cites W2068739830 @default.
- W2789326366 cites W2072394892 @default.
- W2789326366 cites W2079777624 @default.
- W2789326366 cites W2084306351 @default.
- W2789326366 cites W2089969489 @default.
- W2789326366 cites W2096011465 @default.
- W2789326366 cites W2098356010 @default.
- W2789326366 cites W2101893151 @default.
- W2789326366 cites W2108594108 @default.
- W2789326366 cites W2111954828 @default.
- W2789326366 cites W2111964212 @default.
- W2789326366 cites W2120450507 @default.
- W2789326366 cites W2128663764 @default.
- W2789326366 cites W2137678309 @default.
- W2789326366 cites W2139334516 @default.
- W2789326366 cites W2139977642 @default.
- W2789326366 cites W2141797256 @default.
- W2789326366 cites W2150170782 @default.
- W2789326366 cites W2163656014 @default.
- W2789326366 cites W2167153608 @default.
- W2789326366 cites W2168970170 @default.
- W2789326366 cites W2312227080 @default.
- W2789326366 cites W2331327913 @default.
- W2789326366 cites W2479705541 @default.
- W2789326366 cites W4212766227 @default.
- W2789326366 doi "https://doi.org/10.1016/j.bmc.2018.01.031" @default.
- W2789326366 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6071666" @default.
- W2789326366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29439916" @default.
- W2789326366 hasPublicationYear "2018" @default.
- W2789326366 type Work @default.
- W2789326366 sameAs 2789326366 @default.
- W2789326366 citedByCount "18" @default.
- W2789326366 countsByYear W27893263662018 @default.
- W2789326366 countsByYear W27893263662019 @default.
- W2789326366 countsByYear W27893263662020 @default.
- W2789326366 countsByYear W27893263662021 @default.
- W2789326366 countsByYear W27893263662022 @default.
- W2789326366 countsByYear W27893263662023 @default.
- W2789326366 crossrefType "journal-article" @default.
- W2789326366 hasAuthorship W2789326366A5003759585 @default.
- W2789326366 hasAuthorship W2789326366A5016622484 @default.
- W2789326366 hasAuthorship W2789326366A5022439109 @default.
- W2789326366 hasAuthorship W2789326366A5028807063 @default.
- W2789326366 hasAuthorship W2789326366A5036796481 @default.
- W2789326366 hasAuthorship W2789326366A5046327468 @default.
- W2789326366 hasAuthorship W2789326366A5053663279 @default.
- W2789326366 hasAuthorship W2789326366A5058794772 @default.
- W2789326366 hasAuthorship W2789326366A5060785468 @default.
- W2789326366 hasAuthorship W2789326366A5087766294 @default.
- W2789326366 hasAuthorship W2789326366A5090708858 @default.
- W2789326366 hasBestOaLocation W27893263662 @default.
- W2789326366 hasConcept C104317684 @default.
- W2789326366 hasConcept C107459253 @default.
- W2789326366 hasConcept C145103041 @default.
- W2789326366 hasConcept C148738053 @default.
- W2789326366 hasConcept C153911025 @default.