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• W2789331034 abstract "ObjectiveTo review the association between orthostatic intolerance syndromes and both joint hypermobility and Ehlers-Danlos syndrome, and to propose reasons for identifying hereditary connective tissue disorders in those with orthostatic intolerance in the context of both clinical care and research.MethodsWe searched the published peer-reviewed medical literature for papers reporting an association between joint hypermobility or Ehlers-Danlos syndrome and orthostatic intolerance.ResultsWe identified 10 relevant papers. Although methodological variability between studies introduces some limitations, the published literature consistently identifies a significantly higher prevalence of orthostatic intolerance symptoms in patients with joint hypermobility or Ehlers-Danlos syndrome than in healthy controls, and a significantly higher prevalence of cardiovascular and autonomic abnormalities both at rest and during orthostatic challenge. Postural tachycardia syndrome is the most commonly recognized circulatory disorder. The severity of orthostatic symptoms in those with EDS correlates with impairments in quality of life.ConclusionThere is a strong association between several forms of cardiovascular dysfunction, most notably postural tachycardia syndrome, and joint hypermobility or Ehlers-Danlos syndrome. We propose that recognition of joint hypermobility and Ehlers-Danlos syndrome among those with orthostatic intolerance syndromes has the potential to improve clinical care and the validity of research findings." @default.
• W2789331034 created "2018-03-29" @default.
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• W2789331034 date "2018-12-01" @default.
• W2789331034 modified "2023-10-18" @default.
• W2789331034 title "Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome" @default.
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• W2789331034 doi "https://doi.org/10.1016/j.autneu.2018.02.006" @default.
• W2789331034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29519641" @default.
• W2789331034 hasPublicationYear "2018" @default.
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