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- W2789342215 abstract "Irritable bowel syndrome (IBS) is a functional bowel disorder associated with abdominal pain and alterations in bowel habits. The presence of IBS greatly impairs patients' quality of life and imposes a high economic burden on the community; thus, there is intense pressure to reveal its elusive pathogenesis. Many etiological mechanisms have been implicated, but the pathophysiology of the syndrome remains unclear. As a result, novel drug development has been slow and no pharmacological intervention is universally accepted. A growing evidence implicates the role of low-grade inflammation and innate immune system dysfunction, although contradictory results have frequently been presented. Mast cells (MC), eosinophils and other key immune cells together with their mediators seem to play an important role, at least in subgroups of IBS patients. Cytokine imbalance in the systematic circulation and in the intestinal mucosa may also characterize IBS presentation. Toll-like receptors and their emerging role in pathogen recognition have also been highlighted recently, as dysregulation has been reported to occur in patients with IBS. This review summarizes the current knowledge regarding the involvement of any immunological alteration in the development of IBS. There is substantial evidence to support innate immune system dysfunction in several IBS phenotypes, but additional studies are required to better clarify the underlying pathogenetic pathways. IBS heterogeneity could potentially be attributed to multiple causes that lead to different disease phenotypes, thus explaining the variability found between study results." @default.
- W2789342215 created "2018-03-29" @default.
- W2789342215 creator A5022529525 @default.
- W2789342215 creator A5087679429 @default.
- W2789342215 date "2018-01-01" @default.
- W2789342215 modified "2023-10-12" @default.
- W2789342215 title "Current insights into the innate immune system dysfunction in irritable bowel syndrome" @default.
- W2789342215 cites W1483462250 @default.
- W2789342215 cites W1489744161 @default.
- W2789342215 cites W1501080220 @default.
- W2789342215 cites W1537609538 @default.
- W2789342215 cites W1542508778 @default.
- W2789342215 cites W1571292455 @default.
- W2789342215 cites W1583019213 @default.
- W2789342215 cites W1583137842 @default.
- W2789342215 cites W165675192 @default.
- W2789342215 cites W1713503833 @default.
- W2789342215 cites W1773263502 @default.
- W2789342215 cites W1863394710 @default.
- W2789342215 cites W1876060755 @default.
- W2789342215 cites W1897161389 @default.
- W2789342215 cites W1936160580 @default.
- W2789342215 cites W1963579052 @default.
- W2789342215 cites W1964558472 @default.
- W2789342215 cites W1966575505 @default.
- W2789342215 cites W1969462002 @default.
- W2789342215 cites W1970178265 @default.
- W2789342215 cites W1972266470 @default.
- W2789342215 cites W1972565216 @default.
- W2789342215 cites W1973325134 @default.
- W2789342215 cites W1974114749 @default.
- W2789342215 cites W1976068711 @default.
- W2789342215 cites W1976118863 @default.
- W2789342215 cites W1980572807 @default.
- W2789342215 cites W1981140923 @default.
- W2789342215 cites W1981935700 @default.
- W2789342215 cites W1982276170 @default.
- W2789342215 cites W1982930075 @default.
- W2789342215 cites W1986515052 @default.
- W2789342215 cites W1988136067 @default.
- W2789342215 cites W1988317557 @default.
- W2789342215 cites W1989009190 @default.
- W2789342215 cites W1993145105 @default.
- W2789342215 cites W1993745956 @default.
- W2789342215 cites W1996118965 @default.
- W2789342215 cites W1999359264 @default.
- W2789342215 cites W1999576842 @default.
- W2789342215 cites W2000275267 @default.
- W2789342215 cites W2000293868 @default.
- W2789342215 cites W2003196086 @default.
- W2789342215 cites W2004740947 @default.
- W2789342215 cites W2008709508 @default.
- W2789342215 cites W2009916712 @default.
- W2789342215 cites W2012006259 @default.
- W2789342215 cites W2012163637 @default.
- W2789342215 cites W2013153306 @default.
- W2789342215 cites W2016997092 @default.
- W2789342215 cites W2021023116 @default.
- W2789342215 cites W2026368242 @default.
- W2789342215 cites W2028310158 @default.
- W2789342215 cites W2028889492 @default.
- W2789342215 cites W2028890830 @default.
- W2789342215 cites W2030153228 @default.
- W2789342215 cites W2030322777 @default.
- W2789342215 cites W2030383697 @default.
- W2789342215 cites W2032901281 @default.
- W2789342215 cites W2033889517 @default.
- W2789342215 cites W2035657885 @default.
- W2789342215 cites W2035954008 @default.
- W2789342215 cites W2037969942 @default.
- W2789342215 cites W2040780867 @default.
- W2789342215 cites W2042232360 @default.
- W2789342215 cites W2042307743 @default.
- W2789342215 cites W2042433863 @default.
- W2789342215 cites W2044333985 @default.
- W2789342215 cites W2044513342 @default.
- W2789342215 cites W2048998350 @default.
- W2789342215 cites W2052749982 @default.
- W2789342215 cites W2053798991 @default.
- W2789342215 cites W2056707130 @default.
- W2789342215 cites W2057051139 @default.
- W2789342215 cites W2058272774 @default.
- W2789342215 cites W2059270078 @default.
- W2789342215 cites W2059805968 @default.
- W2789342215 cites W2066798524 @default.
- W2789342215 cites W2069870942 @default.
- W2789342215 cites W2070303560 @default.
- W2789342215 cites W2070940867 @default.
- W2789342215 cites W2076240988 @default.
- W2789342215 cites W2079733143 @default.
- W2789342215 cites W2080290298 @default.
- W2789342215 cites W2083076478 @default.
- W2789342215 cites W2085709110 @default.
- W2789342215 cites W2087717115 @default.
- W2789342215 cites W2089254030 @default.
- W2789342215 cites W2089503694 @default.
- W2789342215 cites W2089752133 @default.
- W2789342215 cites W2105958485 @default.
- W2789342215 cites W2108467663 @default.
- W2789342215 cites W2111819970 @default.