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• W2789342847 abstract "Combined application of tenuigenin and beta-asarone improved the efficacy of memantine in treating moderate-to-severe Alzheimer's disease Wenguang Chang,1 Junfang Teng2 1Department of Neurology, Xinxiang Central Hospital, Xinxiang, Henan, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, People’s Republic of China Background: Alzheimer’s disease (AD) is a slowly progressive neurodegenerative disease which cannot be cured at present. The aim of this study was to assess whether the combined application of β-asarone and tenuigenin could improve the efficacy of memantine in treating moderate-to-severe AD.Patients and methods: One hundred and fifty-two patients with moderate-to-severe AD were recruited and assigned to two groups. Patients in the experiment group received β-asarone 10 mg/d, tenuigenin 10 mg/d, and memantine 5–20 mg/d. Patients in the control group only received memantine 5–20 mg/d. The Mini Mental State Examination (MMSE), Clinical Dementia Rating Scale (CDR), and Activities of Daily Living (ADL) were used to assess the therapeutic effects. The drug-related adverse events were used to assess the safety and acceptability. Treatment was continued for 12 weeks.Results: After 12 weeks of treatment, the average MMSE scores, ADL scores, and CDR scores in the two groups were significantly improved. But, compared to the control group, the experimental group had a significantly higher average MMSE score (p" @default.
• W2789342847 created "2018-03-29" @default.
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• W2789342847 date "2018-03-01" @default.
• W2789342847 modified "2023-10-13" @default.
• W2789342847 title "Combined application of tenuigenin and &beta;-asarone improved the efficacy of memantine in treating moderate-to-severe Alzheimer&rsquo;s disease" @default.
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• W2789342847 doi "https://doi.org/10.2147/dddt.s155567" @default.
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