FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789364012> ?p ?o ?g. }

• W2789364012 endingPage "12878" @default.
• W2789364012 startingPage "12868" @default.
• W2789364012 abstract "MicroRNAs have been shown to play important roles in breast cancer progression and can serve as biomarkers. To assess the prognostic role of a panel of miRNAs in breast cancer, we collected plasma prospectively at the time of initial diagnosis from 1,780 patients with stage I-III breast cancer prior to definitive treatment. We identified plasma from 115 patients who subsequently developed distant metastases and 115 patients without metastatic disease. Both groups were matched by: age at blood collection, year of blood collection, breast cancer subtype, and stage. The median follow up was 3.4 years (range, 1-9 years). We extracted RNA from plasma and analyzed the expression of 800 miRNAs using Nanostring technology. We then assessed the expression of miRNAs in primary and metastatic breast cancer samples from The Cancer Genome Atlas (TCGA). We found that, miR-24-3p was upregulated in patients with metastases, both in plasma and in breast cancer tissues. Patients whose primary tumors expressed high levels of miR-24-3p had a significantly lower survival rate compared to patients with low mir-24-3p levels in the TCGA cohort (n=1,024). RNA-Seq data of the samples with the highest miR-24-3p expression versus those with the lowest miR-24-3p in the TCGA cohort identified a specific gene expression signature for those tumors with high miR-24-3p. Possible target genes for miR-24-3p were predicted based on gene expression and binding site, and their effects on cancer pathways were evaluated. Cancer, breast cancer and proteoglycans were the top three pathways affected by miR-24-3p overexpression." @default.
• W2789364012 created "2018-03-29" @default.
• W2789364012 creator A5005668835 @default.
• W2789364012 creator A5023674071 @default.
• W2789364012 creator A5025018584 @default.
• W2789364012 creator A5026383172 @default.
• W2789364012 creator A5031645976 @default.
• W2789364012 creator A5038281776 @default.
• W2789364012 creator A5051845185 @default.
• W2789364012 creator A5055135694 @default.
• W2789364012 creator A5062735077 @default.
• W2789364012 creator A5066957198 @default.
• W2789364012 creator A5086130553 @default.
• W2789364012 creator A5087724207 @default.
• W2789364012 creator A5088180596 @default.
• W2789364012 date "2018-02-05" @default.
• W2789364012 modified "2023-10-18" @default.
• W2789364012 title "Prognostic role of elevated mir-24-3p in breast cancer and its association with the metastatic process" @default.
• W2789364012 cites W1482814115 @default.
• W2789364012 cites W1519070462 @default.
• W2789364012 cites W1855152906 @default.
• W2789364012 cites W1965371218 @default.
• W2789364012 cites W1988622440 @default.
• W2789364012 cites W2004280628 @default.
• W2789364012 cites W2006616601 @default.
• W2789364012 cites W2017219619 @default.
• W2789364012 cites W2018045963 @default.
• W2789364012 cites W2035618305 @default.
• W2789364012 cites W2049599287 @default.
• W2789364012 cites W2056230262 @default.
• W2789364012 cites W2088640649 @default.
• W2789364012 cites W2096949802 @default.
• W2789364012 cites W2107971544 @default.
• W2789364012 cites W2122929031 @default.
• W2789364012 cites W2158804744 @default.
• W2789364012 cites W2169030642 @default.
• W2789364012 cites W2509815162 @default.
• W2789364012 cites W2516965353 @default.
• W2789364012 cites W2544787839 @default.
• W2789364012 cites W2562560179 @default.
• W2789364012 cites W2570618306 @default.
• W2789364012 cites W2571630699 @default.
• W2789364012 cites W2581983145 @default.
• W2789364012 cites W2601639859 @default.
• W2789364012 cites W2612264870 @default.
• W2789364012 cites W2617077704 @default.
• W2789364012 doi "https://doi.org/10.18632/oncotarget.24403" @default.
• W2789364012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5849180" @default.
• W2789364012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29560116" @default.
• W2789364012 hasPublicationYear "2018" @default.
• W2789364012 type Work @default.
• W2789364012 sameAs 2789364012 @default.
• W2789364012 citedByCount "45" @default.
• W2789364012 countsByYear W27893640122019 @default.
• W2789364012 countsByYear W27893640122020 @default.
• W2789364012 countsByYear W27893640122021 @default.
• W2789364012 countsByYear W27893640122022 @default.
• W2789364012 countsByYear W27893640122023 @default.
• W2789364012 crossrefType "journal-article" @default.
• W2789364012 hasAuthorship W2789364012A5005668835 @default.
• W2789364012 hasAuthorship W2789364012A5023674071 @default.
• W2789364012 hasAuthorship W2789364012A5025018584 @default.
• W2789364012 hasAuthorship W2789364012A5026383172 @default.
• W2789364012 hasAuthorship W2789364012A5031645976 @default.
• W2789364012 hasAuthorship W2789364012A5038281776 @default.
• W2789364012 hasAuthorship W2789364012A5051845185 @default.
• W2789364012 hasAuthorship W2789364012A5055135694 @default.
• W2789364012 hasAuthorship W2789364012A5062735077 @default.
• W2789364012 hasAuthorship W2789364012A5066957198 @default.
• W2789364012 hasAuthorship W2789364012A5086130553 @default.
• W2789364012 hasAuthorship W2789364012A5087724207 @default.
• W2789364012 hasAuthorship W2789364012A5088180596 @default.
• W2789364012 hasBestOaLocation W27893640121 @default.
• W2789364012 hasConcept C104317684 @default.
• W2789364012 hasConcept C118646709 @default.
• W2789364012 hasConcept C121608353 @default.
• W2789364012 hasConcept C126322002 @default.
• W2789364012 hasConcept C143998085 @default.
• W2789364012 hasConcept C145059251 @default.
• W2789364012 hasConcept C146357865 @default.
• W2789364012 hasConcept C151730666 @default.
• W2789364012 hasConcept C2775930923 @default.
• W2789364012 hasConcept C2779013556 @default.
• W2789364012 hasConcept C530470458 @default.
• W2789364012 hasConcept C55493867 @default.
• W2789364012 hasConcept C71924100 @default.
• W2789364012 hasConcept C72563966 @default.
• W2789364012 hasConcept C86803240 @default.
• W2789364012 hasConceptScore W2789364012C104317684 @default.
• W2789364012 hasConceptScore W2789364012C118646709 @default.
• W2789364012 hasConceptScore W2789364012C121608353 @default.
• W2789364012 hasConceptScore W2789364012C126322002 @default.
• W2789364012 hasConceptScore W2789364012C143998085 @default.
• W2789364012 hasConceptScore W2789364012C145059251 @default.
• W2789364012 hasConceptScore W2789364012C146357865 @default.
• W2789364012 hasConceptScore W2789364012C151730666 @default.
• W2789364012 hasConceptScore W2789364012C2775930923 @default.
• W2789364012 hasConceptScore W2789364012C2779013556 @default.

• next