FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W27894067> ?p ?o ?g. }

• W27894067 abstract "Understanding the mechanisms of toxicity of xenobiotics in living system requires considering the molecular mechanisms involved as well as the relationships across route, level, and duration of exposure for the target tissue in question. Toxicity is commonly interpreted as alterations in normal cellular physiology, biochemistry, and morphology, leading to cell injury and in the extreme cell death. Our current knowledge about such relationships has grown considerably over the last two decades. Besides toxicodynamic and toxicokinetic perspectives, genomic, proteomic, and metabolomic dimensions have offered data-intensive in-depth windows into what is transpiring inside a cell. Toxicants can destabilize cellular homeostasis through closely related or highly divergent mechanisms, including indirect relationships and/or cascade effects acting at pretranscriptional to catalytic levels. Some toxic mechanisms produce reactive oxygen species or reactive nitrogen species that target intracellular organelles, causing both reversible and irreversible damage to cellular infrastructure and its functioning. Intracellular targets, including the nucleus, mitochondria, endoplasmic reticulum, and plasma membrane can facilitate or retard toxic events. Likewise, events can be genome-dependent or genome-independent. Interactions across different classes of chemicals resulting in the generation of free radicals and the onset of oxidative stress influence DNA function, redox-sensitive signaling proteins, and signaling pathways to cause toxicity. Understanding the mechanisms of toxicity at the genomic, organellar, subcellular, and cellular levels will grow from our knowledge of the proteome, genome, and/or metabolome, leading to common frameworks that can be used to design agents for cellular defense. Consequently, knowledge about mechanism and mode of action has direct implications for hazard identification and risk assessment, and provides a basis for interpretation of toxicity data, establishment of procedures for antagonizing toxic effects, and protecting workers and the pubic against adverse effects of drugs, chemicals, and natural agents that pose risk to living creatures and the environment." @default.
• W27894067 created "2016-06-24" @default.
• W27894067 creator A5017819392 @default.
• W27894067 creator A5042199020 @default.
• W27894067 creator A5077384419 @default.
• W27894067 creator A5089993153 @default.
• W27894067 date "2014-01-01" @default.
• W27894067 modified "2023-09-24" @default.
• W27894067 title "Mechanisms of Toxicity" @default.
• W27894067 cites W1508358616 @default.
• W27894067 cites W1603593764 @default.
• W27894067 cites W1797297565 @default.
• W27894067 cites W194418407 @default.
• W27894067 cites W1989638687 @default.
• W27894067 cites W1990718388 @default.
• W27894067 cites W2014482425 @default.
• W27894067 cites W2019746623 @default.
• W27894067 cites W2022159597 @default.
• W27894067 cites W2043602177 @default.
• W27894067 cites W2049863417 @default.
• W27894067 cites W2075612049 @default.
• W27894067 cites W2077192394 @default.
• W27894067 cites W2110136270 @default.
• W27894067 cites W2118138338 @default.
• W27894067 cites W2124819757 @default.
• W27894067 cites W2129711491 @default.
• W27894067 cites W2141341794 @default.
• W27894067 cites W2143053936 @default.
• W27894067 cites W2157893072 @default.
• W27894067 cites W2160475597 @default.
• W27894067 cites W2163726983 @default.
• W27894067 cites W2330822022 @default.
• W27894067 doi "https://doi.org/10.1016/b978-0-12-386454-3.00329-8" @default.
• W27894067 hasPublicationYear "2014" @default.
• W27894067 type Work @default.
• W27894067 sameAs 27894067 @default.
• W27894067 citedByCount "0" @default.
• W27894067 crossrefType "book-chapter" @default.
• W27894067 hasAuthorship W27894067A5017819392 @default.
• W27894067 hasAuthorship W27894067A5042199020 @default.
• W27894067 hasAuthorship W27894067A5077384419 @default.
• W27894067 hasAuthorship W27894067A5089993153 @default.
• W27894067 hasConcept C104317684 @default.
• W27894067 hasConcept C104397665 @default.
• W27894067 hasConcept C111472728 @default.
• W27894067 hasConcept C135870905 @default.
• W27894067 hasConcept C138885662 @default.
• W27894067 hasConcept C141231307 @default.
• W27894067 hasConcept C1491633281 @default.
• W27894067 hasConcept C158617107 @default.
• W27894067 hasConcept C178790620 @default.
• W27894067 hasConcept C185592680 @default.
• W27894067 hasConcept C190283241 @default.
• W27894067 hasConcept C195289149 @default.
• W27894067 hasConcept C19749203 @default.
• W27894067 hasConcept C21565614 @default.
• W27894067 hasConcept C2776151105 @default.
• W27894067 hasConcept C28859421 @default.
• W27894067 hasConcept C29730261 @default.
• W27894067 hasConcept C31573885 @default.
• W27894067 hasConcept C55493867 @default.
• W27894067 hasConcept C60644358 @default.
• W27894067 hasConcept C62231903 @default.
• W27894067 hasConcept C78885561 @default.
• W27894067 hasConcept C79879829 @default.
• W27894067 hasConcept C86803240 @default.
• W27894067 hasConcept C89611455 @default.
• W27894067 hasConcept C95444343 @default.
• W27894067 hasConceptScore W27894067C104317684 @default.
• W27894067 hasConceptScore W27894067C104397665 @default.
• W27894067 hasConceptScore W27894067C111472728 @default.
• W27894067 hasConceptScore W27894067C135870905 @default.
• W27894067 hasConceptScore W27894067C138885662 @default.
• W27894067 hasConceptScore W27894067C141231307 @default.
• W27894067 hasConceptScore W27894067C1491633281 @default.
• W27894067 hasConceptScore W27894067C158617107 @default.
• W27894067 hasConceptScore W27894067C178790620 @default.
• W27894067 hasConceptScore W27894067C185592680 @default.
• W27894067 hasConceptScore W27894067C190283241 @default.
• W27894067 hasConceptScore W27894067C195289149 @default.
• W27894067 hasConceptScore W27894067C19749203 @default.
• W27894067 hasConceptScore W27894067C21565614 @default.
• W27894067 hasConceptScore W27894067C2776151105 @default.
• W27894067 hasConceptScore W27894067C28859421 @default.
• W27894067 hasConceptScore W27894067C29730261 @default.
• W27894067 hasConceptScore W27894067C31573885 @default.
• W27894067 hasConceptScore W27894067C55493867 @default.
• W27894067 hasConceptScore W27894067C60644358 @default.
• W27894067 hasConceptScore W27894067C62231903 @default.
• W27894067 hasConceptScore W27894067C78885561 @default.
• W27894067 hasConceptScore W27894067C79879829 @default.
• W27894067 hasConceptScore W27894067C86803240 @default.
• W27894067 hasConceptScore W27894067C89611455 @default.
• W27894067 hasConceptScore W27894067C95444343 @default.
• W27894067 hasLocation W278940671 @default.
• W27894067 hasOpenAccess W27894067 @default.
• W27894067 hasPrimaryLocation W278940671 @default.
• W27894067 hasRelatedWork W196767290 @default.
• W27894067 hasRelatedWork W1990813136 @default.
• W27894067 hasRelatedWork W1991562853 @default.

• next