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- W2789464452 endingPage "1270" @default.
- W2789464452 startingPage "1253" @default.
- W2789464452 abstract "Summary Fungi are prolific producers of natural products routinely screened for biotechnological applications, and those living endophytically within plants attract particular attention because of their purported chemical diversity. However, the harnessing of their biosynthetic potential is hampered by a large and often cryptic phylogenetic and ecological diversity, coupled with a lack of large‐scale natural products' dereplication studies. To guide efforts to discover new chemistries among root‐endophytic fungi, we analyzed the natural products produced by 822 strains using an untargeted UPLC‐ESI‐MS/MS‐based approach and linked the patterns of chemical features to fungal lineages. We detected 17 809 compounds of which 7951 were classified in 1992 molecular families, whereas the remaining were considered unique chemistries. Our approach allowed to annotate 1191 compounds with different degrees of accuracy, many of which had known fungal origins. Approximately 61% of the compounds were specific of a fungal order, and differences were observed across lineages in the diversity and characteristics of their chemistries. Chemical profiles also showed variable chemosystematic values across lineages, ranging from relative homogeneity to high heterogeneity among related fungi. Our results provide an extensive resource to dereplicate fungal natural products and may assist future discovery programs by providing a guide for the selection of target fungi." @default.
- W2789464452 created "2018-03-29" @default.
- W2789464452 creator A5008011657 @default.
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- W2789464452 creator A5069394638 @default.
- W2789464452 date "2018-03-01" @default.
- W2789464452 modified "2023-10-01" @default.
- W2789464452 title "Metabolomics-based chemotaxonomy of root endophytic fungi for natural products discovery" @default.
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- W2789464452 doi "https://doi.org/10.1111/1462-2920.14072" @default.