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• W2789492995 abstract "Background: Nosocomial CNS infection (NI-CNS) is a common and serious complication in neurocritical care patients. Timely, accurate diagnosis of NI-CNS is crucial, yet current infection markers lack specificity and/or sensitivity. Presepsin (PSP) is a novel biomarker of macrophage activation. Its utility in NI-CNS has not been explored. We first determined the normal range of cerebrospinal (CSF) PSP in a control group without brain injury before collecting data on CSF PSP levels in neurocritical care patients. Samples were analysed in four groups defined by systemic and neurological infection status. Results: CSF PSP levels in 15 control patients without neurological injury were 50–100 pg/ml. Ninety-seven CSF samples were collected from 21 neurocritical care patients. In patients without NI-CNS or systemic infection, CSF PSP was 340.4±201.1 pg/ml. Isolated NI-CNS was associated with CSF PSP levels of 640.8±235.5 pg/ml, while levels in systemic infection without NI-CNS were 580.1±329.7 pg/ml. Patients with both NI-CNS and systemic infection had CSF PSP levels of 1047.7±166.2 pg/ml. In neurocritical care patients without systemic infection, a cut-off value of 321 pg/ml gives sensitivity and specificity for NI-CNS of 100% and 58.3% respectively. Conclusions: CSF PSP may prove useful in diagnosing NI-CNS but its current utility is as an additional marker only." @default.
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• W2789492995 date "2018-02-15" @default.
• W2789492995 modified "2023-09-24" @default.
• W2789492995 title "Cerebrospinal Fluid Presepsin As a Marker of Nosocomial Infections of the Central Nervous System: A Prospective Observational Study" @default.
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• W2789492995 doi "https://doi.org/10.3389/fneur.2018.00058" @default.
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