FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789500941> ?p ?o ?g. }

• W2789500941 endingPage "9289" @default.
• W2789500941 startingPage "9280" @default.
• W2789500941 abstract "A variety of microparticles have been proposed for the sustained and localized delivery of drugs with the objective of increasing therapeutic indexes by circumventing filtering organs and biological barriers. Yet, the geometrical, mechanical, and therapeutic properties of such microparticles cannot be simultaneously and independently tailored during the fabrication process to optimize their performance. In this work, a top-down approach is employed to realize micron-sized polymeric particles, called microplates (μPLs), for the sustained release of therapeutic agents. μPLs are square hydrogel particles, with an edge length of 20 μm and a height of 5 μm, made out of poly(lactic- co-glycolic acid) (PLGA). During the synthesis process, the μPL Young's modulus can be varied from 0.6 to 5 MPa by changing the PLGA amounts from 1 to 7.5 mg, without affecting the μPL geometry while matching the properties of the surrounding tissue. Within the porous μPL matrix, different classes of therapeutic payloads can be incorporated including molecular agents, such as anti-inflammatory dexamethasone (DEX), and nanoparticles containing imaging and therapeutic molecules themselves, thus originating a truly hierarchical platform. As a proof of principle, μPLs are loaded with free DEX and 200 nm spherical polymeric nanoparticles, carrying DEX molecules (DEX-SPNs). Electron and fluorescent confocal microscopy analyses document the uniform distribution and stability of molecular and nanoagents within the μPL matrix. This multiscale, hierarchical microparticle releases DEX for at least 10 days. The inclusion of DEX-SPNs serves to minimize the initial burst release and modulate the diffusion of DEX molecules out of the μPL matrix. The biopharmacological and therapeutic properties together with the fine tuning of geometry and mechanical stiffness make μPLs a unique polymeric depot for the potential treatment of cancer, cardiovascular, and chronic, inflammatory diseases." @default.
• W2789500941 created "2018-03-29" @default.
• W2789500941 creator A5005249926 @default.
• W2789500941 creator A5005353006 @default.
• W2789500941 creator A5015917294 @default.
• W2789500941 creator A5021853515 @default.
• W2789500941 creator A5025263470 @default.
• W2789500941 creator A5029111898 @default.
• W2789500941 creator A5030942813 @default.
• W2789500941 creator A5061631250 @default.
• W2789500941 creator A5072654385 @default.
• W2789500941 creator A5076268781 @default.
• W2789500941 creator A5078587078 @default.
• W2789500941 date "2018-02-26" @default.
• W2789500941 modified "2023-09-23" @default.
• W2789500941 title "Hierarchical Microplates as Drug Depots with Controlled Geometry, Rigidity, and Therapeutic Efficacy" @default.
• W2789500941 cites W1802495158 @default.
• W2789500941 cites W1964082418 @default.
• W2789500941 cites W1968583232 @default.
• W2789500941 cites W1987769702 @default.
• W2789500941 cites W1994637095 @default.
• W2789500941 cites W1998380582 @default.
• W2789500941 cites W1998792752 @default.
• W2789500941 cites W2002326417 @default.
• W2789500941 cites W2009805582 @default.
• W2789500941 cites W2015504271 @default.
• W2789500941 cites W2027074098 @default.
• W2789500941 cites W2027147390 @default.
• W2789500941 cites W2032090704 @default.
• W2789500941 cites W2049721521 @default.
• W2789500941 cites W2075997145 @default.
• W2789500941 cites W2089949570 @default.
• W2789500941 cites W2093931331 @default.
• W2789500941 cites W2104440842 @default.
• W2789500941 cites W2104558356 @default.
• W2789500941 cites W2108409199 @default.
• W2789500941 cites W2131424870 @default.
• W2789500941 cites W2132880199 @default.
• W2789500941 cites W2134208433 @default.
• W2789500941 cites W2156557177 @default.
• W2789500941 cites W2164002198 @default.
• W2789500941 cites W2410419349 @default.
• W2789500941 cites W2425706463 @default.
• W2789500941 cites W251198220 @default.
• W2789500941 cites W2545649410 @default.
• W2789500941 cites W2568972635 @default.
• W2789500941 cites W2591932468 @default.
• W2789500941 cites W2752077938 @default.
• W2789500941 doi "https://doi.org/10.1021/acsami.7b19136" @default.
• W2789500941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29481038" @default.
• W2789500941 hasPublicationYear "2018" @default.
• W2789500941 type Work @default.
• W2789500941 sameAs 2789500941 @default.
• W2789500941 citedByCount "17" @default.
• W2789500941 countsByYear W27895009412018 @default.
• W2789500941 countsByYear W27895009412019 @default.
• W2789500941 countsByYear W27895009412020 @default.
• W2789500941 countsByYear W27895009412021 @default.
• W2789500941 countsByYear W27895009412022 @default.
• W2789500941 countsByYear W27895009412023 @default.
• W2789500941 crossrefType "journal-article" @default.
• W2789500941 hasAuthorship W2789500941A5005249926 @default.
• W2789500941 hasAuthorship W2789500941A5005353006 @default.
• W2789500941 hasAuthorship W2789500941A5015917294 @default.
• W2789500941 hasAuthorship W2789500941A5021853515 @default.
• W2789500941 hasAuthorship W2789500941A5025263470 @default.
• W2789500941 hasAuthorship W2789500941A5029111898 @default.
• W2789500941 hasAuthorship W2789500941A5030942813 @default.
• W2789500941 hasAuthorship W2789500941A5061631250 @default.
• W2789500941 hasAuthorship W2789500941A5072654385 @default.
• W2789500941 hasAuthorship W2789500941A5076268781 @default.
• W2789500941 hasAuthorship W2789500941A5078587078 @default.
• W2789500941 hasBestOaLocation W27895009412 @default.
• W2789500941 hasConcept C12554922 @default.
• W2789500941 hasConcept C127413603 @default.
• W2789500941 hasConcept C136229726 @default.
• W2789500941 hasConcept C136525101 @default.
• W2789500941 hasConcept C142724271 @default.
• W2789500941 hasConcept C155672457 @default.
• W2789500941 hasConcept C171250308 @default.
• W2789500941 hasConcept C178790620 @default.
• W2789500941 hasConcept C185592680 @default.
• W2789500941 hasConcept C192562407 @default.
• W2789500941 hasConcept C204787440 @default.
• W2789500941 hasConcept C2777521759 @default.
• W2789500941 hasConcept C2779820397 @default.
• W2789500941 hasConcept C2780165375 @default.
• W2789500941 hasConcept C32909587 @default.
• W2789500941 hasConcept C42360764 @default.
• W2789500941 hasConcept C71924100 @default.
• W2789500941 hasConcept C86803240 @default.
• W2789500941 hasConceptScore W2789500941C12554922 @default.
• W2789500941 hasConceptScore W2789500941C127413603 @default.
• W2789500941 hasConceptScore W2789500941C136229726 @default.
• W2789500941 hasConceptScore W2789500941C136525101 @default.
• W2789500941 hasConceptScore W2789500941C142724271 @default.
• W2789500941 hasConceptScore W2789500941C155672457 @default.
• W2789500941 hasConceptScore W2789500941C171250308 @default.

• next