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- W278950810 abstract "Tricyclic antidepressants, such as desipramine, alter the number and function of α 2 -adrenoceptors in rat brain. Since desipramine is a potent inhibitor of the neuronal uptake of noradrenaline, its effects upon α 2 -adrenergic receptor number and function in rat hippocampus were compared to those of cocaine, a classical inhibitor of noradrenaline uptake. Rats were injected intraperitoneally, twice daily for 1 or 14 days with desipramine, 10 mg/kg, or cocaine, 3 mg/kg. Both drugs decreased the specific binding of [ 3 H]clonidine to neural membranes isolated from the hippocampus. Desipramine also decreased markedly the ability of clonidine to inhibit the release of [ 3 H]noradrenaline from noradrenergic neurons in rat hippocampal slices. In contrast, cocaine did not alter the effects of clonidine on presynaptic hippocampal α 2 -adrenoceptors. Both cocaine and clonidine in vitro enhanced markedly the release of [ 3 H]noradrenaline during field stimulation. These observations indicate that drugs which cause a sustained increase in synaptic noradrenaline content do not necessarily alter the sensitivity to clonidine of presynaptic α 2 -adrenoceptors. Furthermore, they suggest that changes in receptor number as measured by binding studies might reflect alterations in the density of postjunctional α 2 -adrenoceptors." @default.
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- W278950810 date "1991-01-01" @default.
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- W278950810 title "Factors Influencing the Function of Presynaptic α2-adrenoceptors in Rat Brain" @default.
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- W278950810 doi "https://doi.org/10.1016/b978-0-08-041165-1.50018-1" @default.
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