Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789510822> ?p ?o ?g. }
- W2789510822 endingPage "1460" @default.
- W2789510822 startingPage "1438" @default.
- W2789510822 abstract "ABSTRACT As a prevalent post‐translational modification, ubiquitination is essential for many developmental processes. Once covalently attached to the small and conserved polypeptide ubiquitin (Ub), a substrate protein can be directed to perform specific biological functions via its Ub‐modified form. Three sequential catalytic reactions contribute to this process, among which E3 ligases serve to identify target substrates and promote the activated Ub to conjugate to substrate proteins. Ubiquitination has great plasticity, with diverse numbers, topologies and modifications of Ub chains conjugated at different substrate residues adding a layer of complexity that facilitates a huge range of cellular functions. Herein, we highlight key advances in the understanding of ubiquitination in epithelial morphogenesis, with an emphasis on the latest insights into its roles in cellular events involved in polarized epithelial tissue, including cell adhesion, asymmetric localization of polarity determinants and cytoskeletal organization. In addition, the physiological roles of ubiquitination are discussed for typical examples of epithelial morphogenesis, such as lung branching, vascular development and synaptic formation and plasticity. Our increased understanding of ubiquitination in epithelial morphogenesis may provide novel insights into the molecular mechanisms underlying epithelial regeneration and maintenance." @default.
- W2789510822 created "2018-03-29" @default.
- W2789510822 creator A5012170584 @default.
- W2789510822 creator A5027815608 @default.
- W2789510822 creator A5050182903 @default.
- W2789510822 creator A5058345470 @default.
- W2789510822 creator A5074942308 @default.
- W2789510822 date "2018-03-01" @default.
- W2789510822 modified "2023-10-01" @default.
- W2789510822 title "Degradation for better survival? Role of ubiquitination in epithelial morphogenesis" @default.
- W2789510822 cites W1495670272 @default.
- W2789510822 cites W1898920617 @default.
- W2789510822 cites W1958512987 @default.
- W2789510822 cites W1963695792 @default.
- W2789510822 cites W1965634898 @default.
- W2789510822 cites W1966159041 @default.
- W2789510822 cites W1967904525 @default.
- W2789510822 cites W1970139159 @default.
- W2789510822 cites W1972361053 @default.
- W2789510822 cites W1974888020 @default.
- W2789510822 cites W1978677736 @default.
- W2789510822 cites W1979408355 @default.
- W2789510822 cites W1979961462 @default.
- W2789510822 cites W1980185790 @default.
- W2789510822 cites W1980224636 @default.
- W2789510822 cites W1980908755 @default.
- W2789510822 cites W1981276700 @default.
- W2789510822 cites W1982476318 @default.
- W2789510822 cites W1988031203 @default.
- W2789510822 cites W1990587513 @default.
- W2789510822 cites W1993719074 @default.
- W2789510822 cites W1996468220 @default.
- W2789510822 cites W2000291787 @default.
- W2789510822 cites W2003649795 @default.
- W2789510822 cites W2003721954 @default.
- W2789510822 cites W2003788514 @default.
- W2789510822 cites W2005258527 @default.
- W2789510822 cites W2007743151 @default.
- W2789510822 cites W2008096185 @default.
- W2789510822 cites W2008273587 @default.
- W2789510822 cites W2013068694 @default.
- W2789510822 cites W2014227379 @default.
- W2789510822 cites W2015407080 @default.
- W2789510822 cites W2017357821 @default.
- W2789510822 cites W2018008810 @default.
- W2789510822 cites W2019556865 @default.
- W2789510822 cites W2020368859 @default.
- W2789510822 cites W2022278464 @default.
- W2789510822 cites W2022491847 @default.
- W2789510822 cites W2022570365 @default.
- W2789510822 cites W2024322138 @default.
- W2789510822 cites W2026181041 @default.
- W2789510822 cites W2026441469 @default.
- W2789510822 cites W2027923851 @default.
- W2789510822 cites W2028157992 @default.
- W2789510822 cites W2028919524 @default.
- W2789510822 cites W2029794768 @default.
- W2789510822 cites W2031484321 @default.
- W2789510822 cites W2031668046 @default.
- W2789510822 cites W2033555492 @default.
- W2789510822 cites W2035121886 @default.
- W2789510822 cites W2037487430 @default.
- W2789510822 cites W2039747078 @default.
- W2789510822 cites W2040379229 @default.
- W2789510822 cites W2040509817 @default.
- W2789510822 cites W2041225773 @default.
- W2789510822 cites W2044942673 @default.
- W2789510822 cites W2045244036 @default.
- W2789510822 cites W2047512850 @default.
- W2789510822 cites W2048458820 @default.
- W2789510822 cites W2050561023 @default.
- W2789510822 cites W2050665945 @default.
- W2789510822 cites W2050817855 @default.
- W2789510822 cites W2051147623 @default.
- W2789510822 cites W2054294084 @default.
- W2789510822 cites W2056408305 @default.
- W2789510822 cites W2056833504 @default.
- W2789510822 cites W2057234077 @default.
- W2789510822 cites W2057733044 @default.
- W2789510822 cites W2058696685 @default.
- W2789510822 cites W2060098193 @default.
- W2789510822 cites W2061296359 @default.
- W2789510822 cites W2061909885 @default.
- W2789510822 cites W2063090066 @default.
- W2789510822 cites W2063529875 @default.
- W2789510822 cites W2064027874 @default.
- W2789510822 cites W2065264929 @default.
- W2789510822 cites W2065521655 @default.
- W2789510822 cites W2065864607 @default.
- W2789510822 cites W2066528969 @default.
- W2789510822 cites W2068646859 @default.
- W2789510822 cites W2068815614 @default.
- W2789510822 cites W2068996242 @default.
- W2789510822 cites W2069099649 @default.
- W2789510822 cites W2071015335 @default.
- W2789510822 cites W2072133144 @default.
- W2789510822 cites W2073038040 @default.
- W2789510822 cites W2073590266 @default.