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- W2789600232 abstract "Iron is an essential element for most organisms However, free iron and heme, its complex with protoporphyrin IX, can be extremely cytotoxic, due to the production of reactive oxygen species, eventually leading to oxidative stress. Thus, eukaryotic cells control iron availability by regulating its transport, storage and excretion as well as the biosynthesis and degradation of heme. In the genome of Rhodnius prolixus, the vector of Chagas disease, we identified 36 genes related to iron and heme metabolism We performed a comprehensive analysis of these genes, including identification of homologous genes described in other insect genomes. We observed that blood-meal modulates the expression of ferritin, Iron Responsive protein (IRP), Heme Oxygenase (HO) and the heme exporter Feline Leukemia Virus C Receptor (FLVCR), components of major pathways involved in the regulation of iron and heme metabolism, particularly in the posterior midgut (PM), where an intense release of free heme occurs during the course of digestion. Knockdown of these genes impacted the survival of nymphs and adults, as well as molting, oogenesis and embryogenesis at different rates and time-courses. The silencing of FLVCR caused the highest levels of mortality in nymphs and adults and reduced nymph molting. The oogenesis was mildly affected by the diminished expression of all of the genes whereas embryogenesis was dramatically impaired by the knockdown of ferritin expression. Furthermore, an intense production of ROS in the midgut of blood-fed insects occurs when the expression of ferritin, but not HO, was inhibited. In this manner, the degradation of dietary heme inside the enterocytes may represent an oxidative challenge that is counteracted by ferritins, conferring to this protein a major antioxidant role. Taken together these results demonstrate that the regulation of iron and heme metabolism is of paramount importance for R. prolixus physiology and imbalances in the levels of these key proteins after a blood- meal can be extremely deleterious to the insects in their various stages of development." @default.
- W2789600232 created "2018-03-29" @default.
- W2789600232 creator A5003699801 @default.
- W2789600232 creator A5043029506 @default.
- W2789600232 creator A5055028751 @default.
- W2789600232 creator A5064536567 @default.
- W2789600232 creator A5088258688 @default.
- W2789600232 date "2018-02-02" @default.
- W2789600232 modified "2023-09-25" @default.
- W2789600232 title "Silencing of Iron and Heme-Related Genes Revealed a Paramount Role of Iron in the Physiology of the Hematophagous Vector Rhodnius prolixus" @default.
- W2789600232 cites W1486095783 @default.
- W2789600232 cites W1491935126 @default.
- W2789600232 cites W1504481059 @default.
- W2789600232 cites W1515226261 @default.
- W2789600232 cites W1538215925 @default.
- W2789600232 cites W1540660343 @default.
- W2789600232 cites W1568628619 @default.
- W2789600232 cites W1572334445 @default.
- W2789600232 cites W1586487499 @default.
- W2789600232 cites W1655162787 @default.
- W2789600232 cites W1767772592 @default.
- W2789600232 cites W1858306036 @default.
- W2789600232 cites W1891909707 @default.
- W2789600232 cites W1894349431 @default.
- W2789600232 cites W1963821042 @default.
- W2789600232 cites W1966047761 @default.
- W2789600232 cites W1967604392 @default.
- W2789600232 cites W1969145875 @default.
- W2789600232 cites W1970717313 @default.
- W2789600232 cites W1972762224 @default.
- W2789600232 cites W1972998779 @default.
- W2789600232 cites W1975005195 @default.
- W2789600232 cites W1979628099 @default.
- W2789600232 cites W1988162534 @default.
- W2789600232 cites W1989584376 @default.
- W2789600232 cites W1991473472 @default.
- W2789600232 cites W2007058458 @default.
- W2789600232 cites W2014126009 @default.
- W2789600232 cites W2014448260 @default.
- W2789600232 cites W2019209742 @default.
- W2789600232 cites W2020280042 @default.
- W2789600232 cites W2024199244 @default.
- W2789600232 cites W2029325030 @default.
- W2789600232 cites W2029619674 @default.
- W2789600232 cites W2029687435 @default.
- W2789600232 cites W2030211149 @default.
- W2789600232 cites W2030750846 @default.
- W2789600232 cites W2032587412 @default.
- W2789600232 cites W2033907571 @default.
- W2789600232 cites W2037808614 @default.
- W2789600232 cites W2039350093 @default.
- W2789600232 cites W2046179489 @default.
- W2789600232 cites W2048160714 @default.
- W2789600232 cites W2053188966 @default.
- W2789600232 cites W2060146432 @default.
- W2789600232 cites W2061012329 @default.
- W2789600232 cites W2071219983 @default.
- W2789600232 cites W2077328361 @default.
- W2789600232 cites W2077581849 @default.
- W2789600232 cites W2079050531 @default.
- W2789600232 cites W2082089700 @default.
- W2789600232 cites W2082228479 @default.
- W2789600232 cites W2082971144 @default.
- W2789600232 cites W2083022144 @default.
- W2789600232 cites W2089047063 @default.
- W2789600232 cites W2098575999 @default.
- W2789600232 cites W2099645196 @default.
- W2789600232 cites W2100673873 @default.
- W2789600232 cites W2103718376 @default.
- W2789600232 cites W2105749655 @default.
- W2789600232 cites W2106447915 @default.
- W2789600232 cites W2106485075 @default.
- W2789600232 cites W2107277218 @default.
- W2789600232 cites W2107704801 @default.
- W2789600232 cites W2128859454 @default.
- W2789600232 cites W2132492733 @default.
- W2789600232 cites W2134946800 @default.
- W2789600232 cites W2137424160 @default.
- W2789600232 cites W2138240475 @default.
- W2789600232 cites W2141052558 @default.
- W2789600232 cites W2141816565 @default.
- W2789600232 cites W2148738130 @default.
- W2789600232 cites W2152770371 @default.
- W2789600232 cites W2168499200 @default.
- W2789600232 cites W2175693398 @default.
- W2789600232 cites W2182565168 @default.
- W2789600232 cites W2192080449 @default.
- W2789600232 cites W2289248796 @default.
- W2789600232 cites W2305030251 @default.
- W2789600232 cites W2399753449 @default.
- W2789600232 cites W2415907905 @default.
- W2789600232 cites W2580415908 @default.
- W2789600232 cites W2609207099 @default.
- W2789600232 cites W261351262 @default.
- W2789600232 cites W2725225667 @default.
- W2789600232 cites W2748418643 @default.
- W2789600232 cites W3082816727 @default.
- W2789600232 cites W3216995939 @default.
- W2789600232 cites W4213134081 @default.
- W2789600232 doi "https://doi.org/10.3389/fgene.2018.00019" @default.