FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789600605> ?p ?o ?g. }

• W2789600605 endingPage "e0192297" @default.
• W2789600605 startingPage "e0192297" @default.
• W2789600605 abstract "Due to its strong proliferation-reducing effects on keratinocytes, and also anti-inflammatory properties, the isoflavone genistein has already been proposed as a possible antipsoriatic compound. As there is still no detailed information on this topic, we examined the effects of genistein by using an in vitro model of both, normal and “psoriasis-like” keratinocytes at this stage of our work exhaustively testing the selected flavonoid in a mono-treated experimental design. Gene expression studies revealed transcriptional changes that confirms known disease-associated pathways and highlights many psoriasis-related genes. Our results suggested that aberrant expression of genes contributing to the progress of psoriasis could be improved by the action of genistein. Genistein prevented “cytokine mix” as well as TNF-α-induced NF-κB nuclear translocation, with no effect on the PI3K signaling cascade, indicating the luck of turning this pathway into NF-κB activation. It could have attenuated TNF-α and LPS-induced inflammatory responses by suppressing ROS activation. Regardless of the type of keratinocyte stimulation used, reduction of cytokine IL-8, IL-20 and CCL2 production (both at RNA and protein level) following genistein treatment was visible. Because investigations of other groups supported our commentary on potential administration of genistein as a potential weapon in the armamentarium against psoriasis, it is believed that this paper should serve to encourage researchers to conduct further studies on this subject." @default.
• W2789600605 created "2018-03-29" @default.
• W2789600605 creator A5009790182 @default.
• W2789600605 creator A5010712065 @default.
• W2789600605 creator A5020106406 @default.
• W2789600605 creator A5060642903 @default.
• W2789600605 creator A5063125955 @default.
• W2789600605 creator A5064047776 @default.
• W2789600605 creator A5067992257 @default.
• W2789600605 creator A5080493453 @default.
• W2789600605 date "2018-02-14" @default.
• W2789600605 modified "2023-10-17" @default.
• W2789600605 title "Molecular action of isoflavone genistein in the human epithelial cell line HaCaT" @default.
• W2789600605 cites W122631512 @default.
• W2789600605 cites W132588340 @default.
• W2789600605 cites W14495360 @default.
• W2789600605 cites W1522182824 @default.
• W2789600605 cites W152802339 @default.
• W2789600605 cites W1905423691 @default.
• W2789600605 cites W1949695329 @default.
• W2789600605 cites W1963588349 @default.
• W2789600605 cites W1964895626 @default.
• W2789600605 cites W1964993095 @default.
• W2789600605 cites W1968731581 @default.
• W2789600605 cites W1969274790 @default.
• W2789600605 cites W1976639539 @default.
• W2789600605 cites W1977935207 @default.
• W2789600605 cites W1984846010 @default.
• W2789600605 cites W1987453282 @default.
• W2789600605 cites W1991230459 @default.
• W2789600605 cites W2000699501 @default.
• W2789600605 cites W2004671403 @default.
• W2789600605 cites W2010795737 @default.
• W2789600605 cites W2011313278 @default.
• W2789600605 cites W2011523436 @default.
• W2789600605 cites W2011885840 @default.
• W2789600605 cites W2013629587 @default.
• W2789600605 cites W2022720370 @default.
• W2789600605 cites W2023561417 @default.
• W2789600605 cites W2032612373 @default.
• W2789600605 cites W2033047513 @default.
• W2789600605 cites W2038963685 @default.
• W2789600605 cites W2039941902 @default.
• W2789600605 cites W2042118950 @default.
• W2789600605 cites W2044565491 @default.
• W2789600605 cites W2047970278 @default.
• W2789600605 cites W2054623554 @default.
• W2789600605 cites W2062706858 @default.
• W2789600605 cites W2070697184 @default.
• W2789600605 cites W2073772412 @default.
• W2789600605 cites W2082280403 @default.
• W2789600605 cites W2086362441 @default.
• W2789600605 cites W2090596338 @default.
• W2789600605 cites W2101546320 @default.
• W2789600605 cites W2103315895 @default.
• W2789600605 cites W2103320679 @default.
• W2789600605 cites W2105422309 @default.
• W2789600605 cites W2112861894 @default.
• W2789600605 cites W2128218039 @default.
• W2789600605 cites W2130410032 @default.
• W2789600605 cites W2135383358 @default.
• W2789600605 cites W2143464311 @default.
• W2789600605 cites W2157432727 @default.
• W2789600605 cites W2205597751 @default.
• W2789600605 cites W2298576674 @default.
• W2789600605 cites W2336000290 @default.
• W2789600605 cites W2355597624 @default.
• W2789600605 cites W239360552 @default.
• W2789600605 cites W2400121309 @default.
• W2789600605 cites W2594286042 @default.
• W2789600605 cites W2769045700 @default.
• W2789600605 cites W4233561050 @default.
• W2789600605 doi "https://doi.org/10.1371/journal.pone.0192297" @default.
• W2789600605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5812592" @default.
• W2789600605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29444128" @default.
• W2789600605 hasPublicationYear "2018" @default.
• W2789600605 type Work @default.
• W2789600605 sameAs 2789600605 @default.
• W2789600605 citedByCount "21" @default.
• W2789600605 countsByYear W27896006052018 @default.
• W2789600605 countsByYear W27896006052019 @default.
• W2789600605 countsByYear W27896006052020 @default.
• W2789600605 countsByYear W27896006052021 @default.
• W2789600605 countsByYear W27896006052022 @default.
• W2789600605 crossrefType "journal-article" @default.
• W2789600605 hasAuthorship W2789600605A5009790182 @default.
• W2789600605 hasAuthorship W2789600605A5010712065 @default.
• W2789600605 hasAuthorship W2789600605A5020106406 @default.
• W2789600605 hasAuthorship W2789600605A5060642903 @default.
• W2789600605 hasAuthorship W2789600605A5063125955 @default.
• W2789600605 hasAuthorship W2789600605A5064047776 @default.
• W2789600605 hasAuthorship W2789600605A5067992257 @default.
• W2789600605 hasAuthorship W2789600605A5080493453 @default.
• W2789600605 hasBestOaLocation W27896006051 @default.
• W2789600605 hasConcept C118995209 @default.
• W2789600605 hasConcept C17991360 @default.
• W2789600605 hasConcept C185592680 @default.
• W2789600605 hasConcept C203014093 @default.

• next