FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789636189> ?p ?o ?g. }

• W2789636189 endingPage "1704" @default.
• W2789636189 startingPage "1691" @default.
• W2789636189 abstract "Abstract Purpose: Pulmonary carcinoid tumors account for up to 5% of all lung malignancies in adults, comprise 30% of all carcinoid malignancies, and are defined histologically as typical carcinoid (TC) and atypical carcinoid (AC) tumors. The role of specific genomic alterations in the pathogenesis of pulmonary carcinoid tumors remains poorly understood. We sought to identify genomic alterations and pathways that are deregulated in these tumors to find novel therapeutic targets for pulmonary carcinoid tumors. Experimental Design: We performed integrated genomic analysis of carcinoid tumors comprising whole genome and exome sequencing, mRNA expression profiling and SNP genotyping of specimens from normal lung, TC and AC, and small cell lung carcinoma (SCLC) to fully represent the lung neuroendocrine tumor spectrum. Results: Analysis of sequencing data found recurrent mutations in cancer genes including ATP1A2, CNNM1, MACF1, RAB38, NF1, RAD51C, TAF1L, EPHB2, POLR3B, and AGFG1. The mutated genes are involved in biological processes including cellular metabolism, cell division cycle, cell death, apoptosis, and immune regulation. The top most significantly mutated genes were TMEM41B, DEFB127, WDYHV1, and TBPL1. Pathway analysis of significantly mutated and cancer driver genes implicated MAPK/ERK and amyloid beta precursor protein (APP) pathways whereas analysis of CNV and gene expression data suggested deregulation of the NF-κB and MAPK/ERK pathways. The mutation signature was predominantly C&gt;T and T&gt;C transitions with a minor contribution of T&gt;G transversions. Conclusions: This study identified mutated genes affecting cancer relevant pathways and biological processes that could provide opportunities for developing targeted therapies for pulmonary carcinoid tumors. Clin Cancer Res; 24(7); 1691–704. ©2018 AACR." @default.
• W2789636189 created "2018-03-29" @default.
• W2789636189 creator A5015371491 @default.
• W2789636189 creator A5016758581 @default.
• W2789636189 creator A5018281509 @default.
• W2789636189 creator A5021419381 @default.
• W2789636189 creator A5029871478 @default.
• W2789636189 creator A5038755935 @default.
• W2789636189 creator A5048399682 @default.
• W2789636189 creator A5059697015 @default.
• W2789636189 creator A5062187239 @default.
• W2789636189 creator A5066001765 @default.
• W2789636189 creator A5067865294 @default.
• W2789636189 creator A5070480124 @default.
• W2789636189 creator A5070955874 @default.
• W2789636189 creator A5086376470 @default.
• W2789636189 date "2018-04-01" @default.
• W2789636189 modified "2023-09-27" @default.
• W2789636189 title "Pathways Impacted by Genomic Alterations in Pulmonary Carcinoid Tumors" @default.
• W2789636189 cites W161611109 @default.
• W2789636189 cites W1822745879 @default.
• W2789636189 cites W1963703199 @default.
• W2789636189 cites W1963987442 @default.
• W2789636189 cites W1969604532 @default.
• W2789636189 cites W1972921461 @default.
• W2789636189 cites W1973702005 @default.
• W2789636189 cites W1992920643 @default.
• W2789636189 cites W1996883110 @default.
• W2789636189 cites W1998607478 @default.
• W2789636189 cites W2003294173 @default.
• W2789636189 cites W2006929818 @default.
• W2789636189 cites W2007456673 @default.
• W2789636189 cites W2009720434 @default.
• W2789636189 cites W2018754160 @default.
• W2789636189 cites W2021763358 @default.
• W2789636189 cites W2024769122 @default.
• W2789636189 cites W2028330103 @default.
• W2789636189 cites W2031159738 @default.
• W2789636189 cites W2031645748 @default.
• W2789636189 cites W2032679444 @default.
• W2789636189 cites W2033918982 @default.
• W2789636189 cites W2034054625 @default.
• W2789636189 cites W2038463413 @default.
• W2789636189 cites W2038530749 @default.
• W2789636189 cites W2047656178 @default.
• W2789636189 cites W2052394132 @default.
• W2789636189 cites W2055402151 @default.
• W2789636189 cites W2056069786 @default.
• W2789636189 cites W2059364018 @default.
• W2789636189 cites W2077605505 @default.
• W2789636189 cites W2084850690 @default.
• W2789636189 cites W2086492959 @default.
• W2789636189 cites W2088720324 @default.
• W2789636189 cites W2094892331 @default.
• W2789636189 cites W2097778464 @default.
• W2789636189 cites W2099257830 @default.
• W2789636189 cites W2104819108 @default.
• W2789636189 cites W2124156632 @default.
• W2789636189 cites W2129136620 @default.
• W2789636189 cites W2137309473 @default.
• W2789636189 cites W2137818224 @default.
• W2789636189 cites W2138155367 @default.
• W2789636189 cites W2141663748 @default.
• W2789636189 cites W2143827882 @default.
• W2789636189 cites W2148019980 @default.
• W2789636189 cites W2148859282 @default.
• W2789636189 cites W2152061559 @default.
• W2789636189 cites W2164118670 @default.
• W2789636189 cites W2166902551 @default.
• W2789636189 cites W2168106545 @default.
• W2789636189 cites W2262425995 @default.
• W2789636189 cites W2275877493 @default.
• W2789636189 cites W2304354332 @default.
• W2789636189 cites W2333692697 @default.
• W2789636189 doi "https://doi.org/10.1158/1078-0432.ccr-17-0252" @default.
• W2789636189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29351916" @default.
• W2789636189 hasPublicationYear "2018" @default.
• W2789636189 type Work @default.
• W2789636189 sameAs 2789636189 @default.
• W2789636189 citedByCount "45" @default.
• W2789636189 countsByYear W27896361892018 @default.
• W2789636189 countsByYear W27896361892019 @default.
• W2789636189 countsByYear W27896361892020 @default.
• W2789636189 countsByYear W27896361892021 @default.
• W2789636189 countsByYear W27896361892022 @default.
• W2789636189 countsByYear W27896361892023 @default.
• W2789636189 crossrefType "journal-article" @default.
• W2789636189 hasAuthorship W2789636189A5015371491 @default.
• W2789636189 hasAuthorship W2789636189A5016758581 @default.
• W2789636189 hasAuthorship W2789636189A5018281509 @default.
• W2789636189 hasAuthorship W2789636189A5021419381 @default.
• W2789636189 hasAuthorship W2789636189A5029871478 @default.
• W2789636189 hasAuthorship W2789636189A5038755935 @default.
• W2789636189 hasAuthorship W2789636189A5048399682 @default.
• W2789636189 hasAuthorship W2789636189A5059697015 @default.
• W2789636189 hasAuthorship W2789636189A5062187239 @default.
• W2789636189 hasAuthorship W2789636189A5066001765 @default.
• W2789636189 hasAuthorship W2789636189A5067865294 @default.

• next