FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789648792> ?p ?o ?g. }

• W2789648792 abstract "A number of novel trials have assessed the efficacy of new lipid-lowering therapies in cardiovascular disease (CVD).Proprotein convertase subtilisin kexin-9 inhibitors reduce low-density lipoprotein cholesterol (LDL-C) by 50-55%. A CVD outcome trial in patients with acute coronary syndromes with evolocumab achieved a LDL-C of 0.8 mmol/l (31 mg/dl) and a 20% relative risk reduction in CVD events in 2.2 years. Cholesterol ester transfer protein inhibitors raise high-density lipoprotein cholesterol and can lower LDL-C. Anacetrapib reduced coronary artery disease events by 7%, but not wider composite CVD outcomes, in a population with chronic CVD with pretreatment LDL-C of 1.6 mmol/l (62 mg/dl). The conflicting outcomes of cholesterol ester transfer protein inhibitor trials means these compounds are not being developed further. Trials using lipid drugs targeting inflammation have previously been generally unsuccessful, but recent data on the interleukin-1B receptor antagonist canakinumab has proven the concept of intervention on inflammation in atherosclerosis by showing a reduction in acute coronary interventions, but at the predictable cost of increased infections.Despite the success of proprotein convertase subtilisin kexin-9 inhibition, the ability to achieve low LDL-C with off-patent medications and the costs of novel therapies will limit their use even in high-risk patients and confine them to the highest-risk sub-groups of patients." @default.
• W2789648792 created "2018-03-29" @default.
• W2789648792 creator A5061183551 @default.
• W2789648792 creator A5066079193 @default.
• W2789648792 creator A5070756199 @default.
• W2789648792 date "2018-07-01" @default.
• W2789648792 modified "2023-09-27" @default.
• W2789648792 title "An update on trials of novel lipid-lowering drugs" @default.
• W2789648792 cites W121888607 @default.
• W2789648792 cites W1423581981 @default.
• W2789648792 cites W1520609538 @default.
• W2789648792 cites W1856460279 @default.
• W2789648792 cites W1870321215 @default.
• W2789648792 cites W1924153976 @default.
• W2789648792 cites W1998569580 @default.
• W2789648792 cites W2014561045 @default.
• W2789648792 cites W2019071303 @default.
• W2789648792 cites W2030507141 @default.
• W2789648792 cites W2030551858 @default.
• W2789648792 cites W2043461445 @default.
• W2789648792 cites W2048760408 @default.
• W2789648792 cites W2054299101 @default.
• W2789648792 cites W2094133329 @default.
• W2789648792 cites W2098890974 @default.
• W2789648792 cites W2103108681 @default.
• W2789648792 cites W2105307761 @default.
• W2789648792 cites W2106285042 @default.
• W2789648792 cites W2106601510 @default.
• W2789648792 cites W2107004670 @default.
• W2789648792 cites W2113187337 @default.
• W2789648792 cites W2115169717 @default.
• W2789648792 cites W2115752151 @default.
• W2789648792 cites W2118825330 @default.
• W2789648792 cites W2120986848 @default.
• W2789648792 cites W2124481954 @default.
• W2789648792 cites W2124964328 @default.
• W2789648792 cites W2127427274 @default.
• W2789648792 cites W2131615550 @default.
• W2789648792 cites W2131900346 @default.
• W2789648792 cites W2134120087 @default.
• W2789648792 cites W2134159541 @default.
• W2789648792 cites W2135905495 @default.
• W2789648792 cites W2144516660 @default.
• W2789648792 cites W2164089346 @default.
• W2789648792 cites W2165605025 @default.
• W2789648792 cites W2166121999 @default.
• W2789648792 cites W2166289410 @default.
• W2789648792 cites W2175680864 @default.
• W2789648792 cites W2194088344 @default.
• W2789648792 cites W2282648998 @default.
• W2789648792 cites W2333497995 @default.
• W2789648792 cites W2402599050 @default.
• W2789648792 cites W2414236137 @default.
• W2789648792 cites W2518107444 @default.
• W2789648792 cites W2519634482 @default.
• W2789648792 cites W2558991743 @default.
• W2789648792 cites W2559592043 @default.
• W2789648792 cites W2559619119 @default.
• W2789648792 cites W2576763875 @default.
• W2789648792 cites W2582534581 @default.
• W2789648792 cites W2583862987 @default.
• W2789648792 cites W2595169180 @default.
• W2789648792 cites W2596179513 @default.
• W2789648792 cites W2596236174 @default.
• W2789648792 cites W2596676407 @default.
• W2789648792 cites W2605234342 @default.
• W2789648792 cites W2609543937 @default.
• W2789648792 cites W2616536890 @default.
• W2789648792 cites W2616658146 @default.
• W2789648792 cites W2738009647 @default.
• W2789648792 cites W2746224452 @default.
• W2789648792 cites W2748400555 @default.
• W2789648792 cites W2749237115 @default.
• W2789648792 cites W2750212817 @default.
• W2789648792 cites W2754562397 @default.
• W2789648792 cites W2762777606 @default.
• W2789648792 cites W2765120344 @default.
• W2789648792 cites W2767900220 @default.
• W2789648792 cites W2768588165 @default.
• W2789648792 doi "https://doi.org/10.1097/hco.0000000000000518" @default.
• W2789648792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29561321" @default.
• W2789648792 hasPublicationYear "2018" @default.
• W2789648792 type Work @default.
• W2789648792 sameAs 2789648792 @default.
• W2789648792 citedByCount "4" @default.
• W2789648792 countsByYear W27896487922019 @default.
• W2789648792 countsByYear W27896487922020 @default.
• W2789648792 crossrefType "journal-article" @default.
• W2789648792 hasAuthorship W2789648792A5061183551 @default.
• W2789648792 hasAuthorship W2789648792A5066079193 @default.
• W2789648792 hasAuthorship W2789648792A5070756199 @default.
• W2789648792 hasConcept C126322002 @default.
• W2789648792 hasConcept C2778114629 @default.
• W2789648792 hasConcept C2778163477 @default.
• W2789648792 hasConcept C2778213512 @default.
• W2789648792 hasConcept C2778824825 @default.
• W2789648792 hasConcept C2778849439 @default.
• W2789648792 hasConcept C2779134260 @default.
• W2789648792 hasConcept C2779725882 @default.
• W2789648792 hasConcept C2780072125 @default.

• next