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• W2789692188 abstract "We report the in vitro drug-likeness studies and in vivo pharmacological evaluation for a new potent 5-HT7 receptor antagonist MF-8 (5-(4-fluorophenyl)-3-(2-hydroxy-3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)-5-methylhydantoin). The in vitro tests showed good permeability, very good metabolic stability, low risk of drug-drug interactions and satisfying safety profile. Moreover, MF-8 showed excellent antidepressant-like activity in the forced swim test in rodents and promising anxiolytic-like activity in the four-plate test in mice. Regarding the potent affinity, high selectivity and antagonistic activity of MF-8 for the 5-HT7 receptor as well as excellent drug - like properties in vitro and confirmed in vivo pharmacological activity, MF-8 should be considered as a very significant molecule in the search for a new class of anti-depressant drugs." @default.
• W2789692188 created "2018-03-29" @default.
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• W2789692188 date "2018-03-01" @default.
• W2789692188 modified "2023-10-17" @default.
• W2789692188 title "MF-8, a novel promising arylpiperazine-hydantoin based 5-HT 7 receptor antagonist: In vitro drug-likeness studies and in vivo pharmacological evaluation" @default.
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• W2789692188 doi "https://doi.org/10.1016/j.bmcl.2018.02.003" @default.
• W2789692188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29439902" @default.
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