Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789699823> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2789699823 abstract "Intensive chemotherapeutic protocols and allogeneic stem cell transplantation continue to represent the mainstay of acute myeloid leukemia (AML) treatment. Although this approach leads to remissions in the majority of patients, long-term disease control remains unsatisfactory as mirrored by overall survival rates of approximately 30%. The reason for this poor outcome is, in part, due to various toxicities associated with traditional AML therapy and the limited ability of most patients to tolerate such treatment. More effective and less toxic therapies therefore represent an unmet need in the management of AML, a disease for which therapeutic progress has been traditionally slow when compared to other cancers. Several studies have shown that leukemic blasts elicit immune responses that could be exploited for the development of novel treatment concepts. To this end, early phase studies of immune-based therapies in AML have delivered encouraging results and demonstrated safety and feasibility. In this review, we discuss opportunities for immunotherapeutic interventions to enhance the potential to achieve a cure in AML, thereby focusing on the role of monoclonal antibodies, hypomethylating agents and the leukemic microenvironment." @default.
- W2789699823 created "2018-03-29" @default.
- W2789699823 creator A5013969487 @default.
- W2789699823 creator A5018335096 @default.
- W2789699823 creator A5051654669 @default.
- W2789699823 creator A5052684200 @default.
- W2789699823 creator A5056697792 @default.
- W2789699823 creator A5067521829 @default.
- W2789699823 creator A5084340674 @default.
- W2789699823 date "2017-07-31" @default.
- W2789699823 modified "2023-09-23" @default.
- W2789699823 title "Immunotherapeutic Concepts to Target Acute Myeloid Leukemia: Focusing on the Role of Monoclonal Antibodies, Hypomethylating Agents and the Leukemic Microenvironment" @default.
- W2789699823 hasPublicationYear "2017" @default.
- W2789699823 type Work @default.
- W2789699823 sameAs 2789699823 @default.
- W2789699823 citedByCount "0" @default.
- W2789699823 crossrefType "journal-article" @default.
- W2789699823 hasAuthorship W2789699823A5013969487 @default.
- W2789699823 hasAuthorship W2789699823A5018335096 @default.
- W2789699823 hasAuthorship W2789699823A5051654669 @default.
- W2789699823 hasAuthorship W2789699823A5052684200 @default.
- W2789699823 hasAuthorship W2789699823A5056697792 @default.
- W2789699823 hasAuthorship W2789699823A5067521829 @default.
- W2789699823 hasAuthorship W2789699823A5084340674 @default.
- W2789699823 hasConcept C104317684 @default.
- W2789699823 hasConcept C126322002 @default.
- W2789699823 hasConcept C143998085 @default.
- W2789699823 hasConcept C150194340 @default.
- W2789699823 hasConcept C159654299 @default.
- W2789699823 hasConcept C190727270 @default.
- W2789699823 hasConcept C203014093 @default.
- W2789699823 hasConcept C2776012956 @default.
- W2789699823 hasConcept C2777701055 @default.
- W2789699823 hasConcept C2778461978 @default.
- W2789699823 hasConcept C2778729363 @default.
- W2789699823 hasConcept C2779134260 @default.
- W2789699823 hasConcept C2779282312 @default.
- W2789699823 hasConcept C2911091166 @default.
- W2789699823 hasConcept C542903549 @default.
- W2789699823 hasConcept C55493867 @default.
- W2789699823 hasConcept C71924100 @default.
- W2789699823 hasConcept C86803240 @default.
- W2789699823 hasConcept C8891405 @default.
- W2789699823 hasConceptScore W2789699823C104317684 @default.
- W2789699823 hasConceptScore W2789699823C126322002 @default.
- W2789699823 hasConceptScore W2789699823C143998085 @default.
- W2789699823 hasConceptScore W2789699823C150194340 @default.
- W2789699823 hasConceptScore W2789699823C159654299 @default.
- W2789699823 hasConceptScore W2789699823C190727270 @default.
- W2789699823 hasConceptScore W2789699823C203014093 @default.
- W2789699823 hasConceptScore W2789699823C2776012956 @default.
- W2789699823 hasConceptScore W2789699823C2777701055 @default.
- W2789699823 hasConceptScore W2789699823C2778461978 @default.
- W2789699823 hasConceptScore W2789699823C2778729363 @default.
- W2789699823 hasConceptScore W2789699823C2779134260 @default.
- W2789699823 hasConceptScore W2789699823C2779282312 @default.
- W2789699823 hasConceptScore W2789699823C2911091166 @default.
- W2789699823 hasConceptScore W2789699823C542903549 @default.
- W2789699823 hasConceptScore W2789699823C55493867 @default.
- W2789699823 hasConceptScore W2789699823C71924100 @default.
- W2789699823 hasConceptScore W2789699823C86803240 @default.
- W2789699823 hasConceptScore W2789699823C8891405 @default.
- W2789699823 hasLocation W27896998231 @default.
- W2789699823 hasOpenAccess W2789699823 @default.
- W2789699823 hasPrimaryLocation W27896998231 @default.
- W2789699823 hasRelatedWork W121203231 @default.
- W2789699823 hasRelatedWork W2004004651 @default.
- W2789699823 hasRelatedWork W2025079459 @default.
- W2789699823 hasRelatedWork W2107200082 @default.
- W2789699823 hasRelatedWork W2154094925 @default.
- W2789699823 hasRelatedWork W2600066303 @default.
- W2789699823 hasRelatedWork W2738658820 @default.
- W2789699823 hasRelatedWork W2741770641 @default.
- W2789699823 hasRelatedWork W2765458733 @default.
- W2789699823 hasRelatedWork W2800781255 @default.
- W2789699823 hasRelatedWork W288116742 @default.
- W2789699823 hasRelatedWork W2989601927 @default.
- W2789699823 hasRelatedWork W3082789331 @default.
- W2789699823 hasRelatedWork W3095432860 @default.
- W2789699823 hasRelatedWork W3139362939 @default.
- W2789699823 hasRelatedWork W3159967509 @default.
- W2789699823 hasRelatedWork W3169367788 @default.
- W2789699823 hasRelatedWork W3177084443 @default.
- W2789699823 hasRelatedWork W3196564705 @default.
- W2789699823 hasRelatedWork W3206550429 @default.
- W2789699823 isParatext "false" @default.
- W2789699823 isRetracted "false" @default.
- W2789699823 magId "2789699823" @default.
- W2789699823 workType "article" @default.