FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789715207> ?p ?o ?g. }

• W2789715207 abstract "In cardiomyocytes, the voltage gated transient outward potassium current (Ito) is responsible for the phase-1 repolarization of the action potential (AP). Gain-of-function mutations in KCND3, the gene encoding the Ito carrying KV4.3 channel, have been associated with Brugada syndrome (BrS). While the role of Ito in the pro-arrhythmic mechanism of BrS has been debated, recent studies have suggested that an increased Ito may directly affect cardiac conduction. However, the effects of an increased Ito on AP upstroke velocity or sodium current at the cellular level remain unknown. We here investigated the consequences of KV4.3 overexpression on NaV1.5 current and consequent sodium channel availability. We found that overexpression of KV4.3 protein in HEK293 cells stably expressing NaV1.5 (HEK293-NaV1.5) significantly reduced NaV1.5 current density without affecting its kinetic properties. In addition, KV4.3 overexpression decreased AP upstroke velocity in HEK293-NaV1.5 cells, as measured with the alternating voltage/current clamp technique. These effects of KV4.3 could not be explained by alterations in total NaV1.5 protein expression. Using computer simulations employing a multicellular in silico model, we furthermore demonstrate that the experimentally observed KV4.3 increase and concurrent NaV1.5 decrease may result in a loss of conduction, underlining the potential functional relevance of our findings. This study gives the first proof of concept that KV4.3 directly impacts on NaV1.5 current. Future studies employing appropriate disease models should explore the potential electrophysiological implications in (patho)physiological conditions, including BrS associated with KCND3 gain-of-function mutations." @default.
• W2789715207 created "2018-03-29" @default.
• W2789715207 creator A5001551018 @default.
• W2789715207 creator A5033167666 @default.
• W2789715207 creator A5035002362 @default.
• W2789715207 creator A5043358966 @default.
• W2789715207 creator A5062680244 @default.
• W2789715207 creator A5085598876 @default.
• W2789715207 date "2018-03-12" @default.
• W2789715207 modified "2023-10-16" @default.
• W2789715207 title "KV4.3 Expression Modulates NaV1.5 Sodium Current" @default.
• W2789715207 cites W1491803208 @default.
• W2789715207 cites W1507105217 @default.
• W2789715207 cites W1540071197 @default.
• W2789715207 cites W1560833314 @default.
• W2789715207 cites W1776982971 @default.
• W2789715207 cites W1965371036 @default.
• W2789715207 cites W1976320150 @default.
• W2789715207 cites W1982054477 @default.
• W2789715207 cites W1990948522 @default.
• W2789715207 cites W1991649249 @default.
• W2789715207 cites W2002823670 @default.
• W2789715207 cites W2003398434 @default.
• W2789715207 cites W2011041203 @default.
• W2789715207 cites W2013876159 @default.
• W2789715207 cites W2025249827 @default.
• W2789715207 cites W2027085605 @default.
• W2789715207 cites W2034867646 @default.
• W2789715207 cites W2055033654 @default.
• W2789715207 cites W2065735566 @default.
• W2789715207 cites W2065925973 @default.
• W2789715207 cites W2069166120 @default.
• W2789715207 cites W2102141674 @default.
• W2789715207 cites W2114516874 @default.
• W2789715207 cites W2123892496 @default.
• W2789715207 cites W2131312817 @default.
• W2789715207 cites W2135662719 @default.
• W2789715207 cites W2135827654 @default.
• W2789715207 cites W2140332009 @default.
• W2789715207 cites W2142550975 @default.
• W2789715207 cites W2149134234 @default.
• W2789715207 cites W2154806697 @default.
• W2789715207 cites W2158368575 @default.
• W2789715207 cites W2158404680 @default.
• W2789715207 cites W2162209435 @default.
• W2789715207 cites W2168377918 @default.
• W2789715207 cites W2170122529 @default.
• W2789715207 cites W2171690845 @default.
• W2789715207 cites W2264523845 @default.
• W2789715207 cites W2414792337 @default.
• W2789715207 cites W2581694765 @default.
• W2789715207 cites W2594101065 @default.
• W2789715207 cites W2695127175 @default.
• W2789715207 cites W2754086446 @default.
• W2789715207 cites W2765612611 @default.
• W2789715207 cites W2766587540 @default.
• W2789715207 cites W2770954044 @default.
• W2789715207 cites W2772358436 @default.
• W2789715207 cites W977050207 @default.
• W2789715207 doi "https://doi.org/10.3389/fphys.2018.00178" @default.
• W2789715207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5857579" @default.
• W2789715207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29593552" @default.
• W2789715207 hasPublicationYear "2018" @default.
• W2789715207 type Work @default.
• W2789715207 sameAs 2789715207 @default.
• W2789715207 citedByCount "25" @default.
• W2789715207 countsByYear W27897152072019 @default.
• W2789715207 countsByYear W27897152072020 @default.
• W2789715207 countsByYear W27897152072021 @default.
• W2789715207 countsByYear W27897152072022 @default.
• W2789715207 countsByYear W27897152072023 @default.
• W2789715207 crossrefType "journal-article" @default.
• W2789715207 hasAuthorship W2789715207A5001551018 @default.
• W2789715207 hasAuthorship W2789715207A5033167666 @default.
• W2789715207 hasAuthorship W2789715207A5035002362 @default.
• W2789715207 hasAuthorship W2789715207A5043358966 @default.
• W2789715207 hasAuthorship W2789715207A5062680244 @default.
• W2789715207 hasAuthorship W2789715207A5085598876 @default.
• W2789715207 hasBestOaLocation W27897152071 @default.
• W2789715207 hasConcept C101404756 @default.
• W2789715207 hasConcept C104317684 @default.
• W2789715207 hasConcept C12554922 @default.
• W2789715207 hasConcept C126322002 @default.
• W2789715207 hasConcept C134018914 @default.
• W2789715207 hasConcept C146403970 @default.
• W2789715207 hasConcept C147944092 @default.
• W2789715207 hasConcept C174510640 @default.
• W2789715207 hasConcept C178790620 @default.
• W2789715207 hasConcept C185263204 @default.
• W2789715207 hasConcept C185592680 @default.
• W2789715207 hasConcept C2776250582 @default.
• W2789715207 hasConcept C2777382798 @default.
• W2789715207 hasConcept C50952357 @default.
• W2789715207 hasConcept C537181965 @default.
• W2789715207 hasConcept C55493867 @default.
• W2789715207 hasConcept C71924100 @default.
• W2789715207 hasConcept C83743174 @default.
• W2789715207 hasConcept C86803240 @default.
• W2789715207 hasConcept C95444343 @default.
• W2789715207 hasConceptScore W2789715207C101404756 @default.

• next