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• W2789720872 abstract "Abstract Articular cartilage (AC) has gradient features in both mechanics and histology as well as a poor regeneration ability. The repair of AC poses difficulties in both research and the clinic. In this paper, a gradient scaffold based on poly(lactic‐ co ‐glycolic acid) (PLGA)‐extracellular matrix was proposed. Cartilage scaffolds with a three‐layer gradient structure were fabricated by PLGA through three‐dimensional printing, and the microstructure orientation and pore fabrication were made by decellularized extracellular matrix injection and directional freezing. The manufactured scaffold has a mechanical strength close to that of real cartilage. A quantitative optimization of the Young's modulus and shear modulus was achieved by material mechanics formulas, which achieved a more accurate mechanical bionic and a more stable interface performance because of the one‐time molding process. At the same time, the scaffolds have a bionic and gradient microstructure orientation and pore size, and the stratification ratio can be quantitatively optimized by design of the freeze box and temperature simulation. In general, this paper provides a method to optimize AC scaffolds by both mechanics and histology as well as a bionic multimaterial scaffold. This paper is of significance for cell culture and clinical transplantation experiments. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1664–1676, 2018." @default.
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• W2789720872 date "2018-03-05" @default.
• W2789720872 modified "2023-10-16" @default.
• W2789720872 title "Construction of bionic tissue engineering cartilage scaffold based on three‐dimensional printing and oriented frozen technology" @default.
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• W2789720872 doi "https://doi.org/10.1002/jbm.a.36368" @default.
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