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- W2789724130 abstract "It has been reported that a growing and heterogeneous group of regulatory cell modulate immune response. In particular, regulation of CD8+ T lymphocyte effector functions is critical for tissue homeostasis and immune tolerance control. Here, we report that the co-expression of CD3 and CD56 molecules identify a novel human regulatory T cell population exerting suppressive activity on proliferation, cytotoxicity and IFN- production of TCR-activated human CD8+ T lymphocytes. Regulatory functions of human circulating CD3+CD56+ T lymphocytes require cell-to-cell contact and are exerted in both autologous and allogeneic conditions. Of note, CD3+CD56+ T cells are reduced and functionally impaired in children affected by Type 1 Diabetes (T1D), at disease onset. Conversely the frequency of this cell subset is increased in patients with prostate cancer.Taken together, our findings reveal that freshly isolated human CD3+CD56+ cells specifically control activation of human CD8+ T lymphocytes. Perturbation of number and function of this cell subset may account for the deranged functions of CD8+ T lymphocytes observed in autoimmune conditions, including T1D. Thus, therapeutic manipulation of CD3+CD56+ cells may represent an innovative approach to restore immune function in T1D." @default.
- W2789724130 created "2018-03-29" @default.
- W2789724130 creator A5077938887 @default.
- W2789724130 date "2017-04-06" @default.
- W2789724130 modified "2023-09-23" @default.
- W2789724130 title "Inflammation in chronic degenerative disorders:A novel CD3+CD56+ subset that regulates CD8+ T cell effector function." @default.
- W2789724130 doi "https://doi.org/10.6093/unina/fedoa/11557" @default.
- W2789724130 hasPublicationYear "2017" @default.
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