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- W2789755208 abstract "The dimorphic fungal pathogen Histoplasma capsulatum takes advantage of the innate immune system, utilizing host macrophages as a proliferative niche while largely avoiding stimulation of signaling host receptors. As a result, innate immune cells are unable to control H. capsulatum on their own. Not all host phagocytes respond to H. capsulatum in the same way, with neutrophils and dendritic cells playing important roles in impeding fungal growth and initiating a protective TH1 response, respectively. Dendritic cells prime T-cell differentiation after internalization of yeasts via VLA-5 receptors and subsequent degradation of the yeasts. Dendritic cell-expressed TLR7 and TLR9 promote a type I interferon response for TH1 polarization. In contrast to dendritic cells, macrophages provide a hospitable intracellular environment. H. capsulatum yeasts enter macrophages via binding to phagocytic receptors. Simultaneously, α-glucan masks immunostimulatory cell wall β-glucans and a secreted endoglucanase removes exposed β-glucans to minimize recognition of yeasts by Dectin-1. This review highlights how phagocytes interact with H. capsulatum yeasts and the mechanisms H. capsulatum uses to limit the innate immune response." @default.
- W2789755208 created "2018-03-29" @default.
- W2789755208 creator A5015420076 @default.
- W2789755208 creator A5057515215 @default.
- W2789755208 date "2019-05-01" @default.
- W2789755208 modified "2023-10-12" @default.
- W2789755208 title "Flying under the radar: Histoplasma capsulatum avoidance of innate immune recognition" @default.
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- W2789755208 cites W1513548357 @default.
- W2789755208 cites W1541666485 @default.
- W2789755208 cites W1576707839 @default.
- W2789755208 cites W1578549591 @default.
- W2789755208 cites W1592903182 @default.
- W2789755208 cites W1600771506 @default.
- W2789755208 cites W1629308315 @default.
- W2789755208 cites W1827682233 @default.
- W2789755208 cites W1843542804 @default.
- W2789755208 cites W1903351493 @default.
- W2789755208 cites W1918118809 @default.
- W2789755208 cites W1959967360 @default.
- W2789755208 cites W1963286479 @default.
- W2789755208 cites W1978521007 @default.
- W2789755208 cites W1997579901 @default.
- W2789755208 cites W2013313335 @default.
- W2789755208 cites W2017807612 @default.
- W2789755208 cites W2021374438 @default.
- W2789755208 cites W2024599485 @default.
- W2789755208 cites W2025828859 @default.
- W2789755208 cites W2026338966 @default.
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- W2789755208 cites W2076464901 @default.
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- W2789755208 doi "https://doi.org/10.1016/j.semcdb.2018.03.009" @default.
- W2789755208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6150853" @default.
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