FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789757430> ?p ?o ?g. }

• W2789757430 endingPage "1700272" @default.
• W2789757430 startingPage "1700272" @default.
• W2789757430 abstract "Drugs used in breast cancer treatments target the suppression of estrogen biosynthesis. During this suppression, the main goal is to inhibit the aromatase enzyme that is responsible for the cyclization and structuring of estrogens either with steroid or non-steroidal-type inhibitors. Non-steroidal derivatives generally have a planar aromatic structure attached to the triazole ring system in their structures, which inhibits hydroxylation reactions during aromatization by coordinating the heme group. Bioisosteric replacement of the triazole ring system and development of aromatic/cyclic structures of the side chain can increase the selectivity for aromatase enzyme inhibition. In this study, pyridine-substituted thiazolylphenol derivatives, which are non-steroidal triazole bioisosteres, were synthesized using the Hantzsch method, and physical analysis and structural determination studies were performed. The IC50 values of the compounds were determined by a fluorescence-based aromatase inhibition assay. Then, their antiproliferative activities on the MCF7 and HEK 293 cell lines were evaluated with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Furthermore, the crystal structure of human placental aromatase was subjected to a series of docking experiments to identify the possible interactions between the most active structure and the active site. Lastly, an in silico technique was performed to analyze and predict the drug-likeness, molecular and ADME properties of the synthesized molecules." @default.
• W2789757430 created "2018-03-29" @default.
• W2789757430 creator A5029275257 @default.
• W2789757430 creator A5031016240 @default.
• W2789757430 creator A5086664655 @default.
• W2789757430 creator A5087222481 @default.
• W2789757430 creator A5090043760 @default.
• W2789757430 creator A5090129265 @default.
• W2789757430 date "2018-03-09" @default.
• W2789757430 modified "2023-09-24" @default.
• W2789757430 title "Pyridine-substituted thiazolylphenol derivatives: Synthesis, modeling studies, aromatase inhibition, and antiproliferative activity evaluation" @default.
• W2789757430 cites W1498768366 @default.
• W2789757430 cites W1634452176 @default.
• W2789757430 cites W1864729394 @default.
• W2789757430 cites W1918073772 @default.
• W2789757430 cites W1932574503 @default.
• W2789757430 cites W1990551275 @default.
• W2789757430 cites W2001028672 @default.
• W2789757430 cites W2016760920 @default.
• W2789757430 cites W2020830322 @default.
• W2789757430 cites W2033801725 @default.
• W2789757430 cites W2039230012 @default.
• W2789757430 cites W2044179782 @default.
• W2789757430 cites W2054702701 @default.
• W2789757430 cites W2055131068 @default.
• W2789757430 cites W2067492598 @default.
• W2789757430 cites W2073392370 @default.
• W2789757430 cites W2079286586 @default.
• W2789757430 cites W2089527664 @default.
• W2789757430 cites W2097582882 @default.
• W2789757430 cites W2098013119 @default.
• W2789757430 cites W2114918609 @default.
• W2789757430 cites W2136780582 @default.
• W2789757430 cites W2141257357 @default.
• W2789757430 cites W2169342391 @default.
• W2789757430 cites W2347157352 @default.
• W2789757430 cites W2516397751 @default.
• W2789757430 cites W2952421497 @default.
• W2789757430 doi "https://doi.org/10.1002/ardp.201700272" @default.
• W2789757430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29522642" @default.
• W2789757430 hasPublicationYear "2018" @default.
• W2789757430 type Work @default.
• W2789757430 sameAs 2789757430 @default.
• W2789757430 citedByCount "16" @default.
• W2789757430 countsByYear W27897574302018 @default.
• W2789757430 countsByYear W27897574302020 @default.
• W2789757430 countsByYear W27897574302021 @default.
• W2789757430 countsByYear W27897574302022 @default.
• W2789757430 countsByYear W27897574302023 @default.
• W2789757430 crossrefType "journal-article" @default.
• W2789757430 hasAuthorship W2789757430A5029275257 @default.
• W2789757430 hasAuthorship W2789757430A5031016240 @default.
• W2789757430 hasAuthorship W2789757430A5086664655 @default.
• W2789757430 hasAuthorship W2789757430A5087222481 @default.
• W2789757430 hasAuthorship W2789757430A5090043760 @default.
• W2789757430 hasAuthorship W2789757430A5090129265 @default.
• W2789757430 hasConcept C104317684 @default.
• W2789757430 hasConcept C121608353 @default.
• W2789757430 hasConcept C159110408 @default.
• W2789757430 hasConcept C178790620 @default.
• W2789757430 hasConcept C181199279 @default.
• W2789757430 hasConcept C185592680 @default.
• W2789757430 hasConcept C193042331 @default.
• W2789757430 hasConcept C202751555 @default.
• W2789757430 hasConcept C21951064 @default.
• W2789757430 hasConcept C2775905019 @default.
• W2789757430 hasConcept C2776166826 @default.
• W2789757430 hasConcept C2777907353 @default.
• W2789757430 hasConcept C2779485729 @default.
• W2789757430 hasConcept C2780783641 @default.
• W2789757430 hasConcept C2780902042 @default.
• W2789757430 hasConcept C2781109383 @default.
• W2789757430 hasConcept C41183919 @default.
• W2789757430 hasConcept C41685203 @default.
• W2789757430 hasConcept C530470458 @default.
• W2789757430 hasConcept C54355233 @default.
• W2789757430 hasConcept C55493867 @default.
• W2789757430 hasConcept C62112901 @default.
• W2789757430 hasConcept C69366308 @default.
• W2789757430 hasConcept C71240020 @default.
• W2789757430 hasConcept C71315377 @default.
• W2789757430 hasConcept C71924100 @default.
• W2789757430 hasConcept C86803240 @default.
• W2789757430 hasConceptScore W2789757430C104317684 @default.
• W2789757430 hasConceptScore W2789757430C121608353 @default.
• W2789757430 hasConceptScore W2789757430C159110408 @default.
• W2789757430 hasConceptScore W2789757430C178790620 @default.
• W2789757430 hasConceptScore W2789757430C181199279 @default.
• W2789757430 hasConceptScore W2789757430C185592680 @default.
• W2789757430 hasConceptScore W2789757430C193042331 @default.
• W2789757430 hasConceptScore W2789757430C202751555 @default.
• W2789757430 hasConceptScore W2789757430C21951064 @default.
• W2789757430 hasConceptScore W2789757430C2775905019 @default.
• W2789757430 hasConceptScore W2789757430C2776166826 @default.
• W2789757430 hasConceptScore W2789757430C2777907353 @default.
• W2789757430 hasConceptScore W2789757430C2779485729 @default.
• W2789757430 hasConceptScore W2789757430C2780783641 @default.
• W2789757430 hasConceptScore W2789757430C2780902042 @default.

• next