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- W2789762246 abstract "Abstract Guest encapsulation is a fundamental property of coordination cages. However, there is a paucity of methods capable of quantifying the dynamics of guest binding processes. Here, we demonstrate nanopore detection of single‐molecule binding within metallosupramolecular cages. Real‐time monitoring of the ion current flowing through a transmembrane α‐hemolysin nanopore resolved the binding of different guests to both cage enantiomers. This enabled the single‐molecule kinetics of guest binding to be quantified, whereas the ordering and durations of events were consistent with a guest‐exchange mechanism that does not involve ligand dissociation. In addition to providing a new approach for single‐molecule interrogation of dynamic supramolecular processes, this work also establishes that cage complexes which are too large to enter the nanopore can be exploited for detecting small molecules, thus constituting a new class of molecular adapter." @default.
- W2789762246 created "2018-03-29" @default.
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- W2789762246 date "2018-03-09" @default.
- W2789762246 modified "2023-09-26" @default.
- W2789762246 title "Nanopore Detection of Single‐Molecule Binding within a Metallosupramolecular Cage" @default.
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- W2789762246 doi "https://doi.org/10.1002/chem.201800760" @default.
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