FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789766211> ?p ?o ?g. }

• W2789766211 endingPage "4092" @default.
• W2789766211 startingPage "4076" @default.
• W2789766211 abstract "Shank2 is an excitatory postsynaptic scaffolding protein implicated in synaptic regulation and psychiatric disorders including autism spectrum disorders. Conventional Shank2 -mutant ( Shank2 −/− ) mice display several autistic-like behaviors, including social deficits, repetitive behaviors, hyperactivity, and anxiety-like behaviors. However, cell-type-specific contributions to these behaviors have remained largely unclear. Here, we deleted Shank2 in specific cell types and found that male mice lacking Shank2 in excitatory neurons ( CaMKII-Cre;Shank2 fl/fl ) show social interaction deficits and mild social communication deficits, hyperactivity, and anxiety-like behaviors. In particular, male mice lacking Shank2 in GABAergic inhibitory neurons ( Viaat-Cre;Shank2 fl/fl ) display social communication deficits, repetitive self-grooming, and mild hyperactivity. These behavioral changes were associated with distinct changes in hippocampal and striatal synaptic transmission in the two mouse lines. These results indicate that cell-type-specific deletions of Shank2 in mice lead to differential synaptic and behavioral abnormalities. SIGNIFICANCE STATEMENT Shank2 is an abundant excitatory postsynaptic scaffolding protein implicated in the regulation of excitatory synapses and diverse psychiatric disorders including autism spectrum disorders. Previous studies have reported in vivo functions of Shank2 mainly using global Shank2 -null mice, but it remains largely unclear how individual cell types contribute to Shank2-dependent regulation of neuronal synapses and behaviors. Here, we have characterized conditional Shank2 -mutant mice carrying the Shank2 deletion in excitatory and inhibitory neurons. These mouse lines display distinct alterations of synaptic transmission in the hippocampus and striatum that are associated with differential behavioral abnormalities in social, repetitive, locomotor, and anxiety-like domains." @default.
• W2789766211 created "2018-03-29" @default.
• W2789766211 creator A5006249061 @default.
• W2789766211 creator A5013204190 @default.
• W2789766211 creator A5015102828 @default.
• W2789766211 creator A5022560171 @default.
• W2789766211 creator A5040291964 @default.
• W2789766211 creator A5040942248 @default.
• W2789766211 creator A5042266270 @default.
• W2789766211 creator A5053781076 @default.
• W2789766211 creator A5075986960 @default.
• W2789766211 creator A5078770664 @default.
• W2789766211 date "2018-03-23" @default.
• W2789766211 modified "2023-10-14" @default.
• W2789766211 title "Cell-Type-Specific<i>Shank2</i>Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes" @default.
• W2789766211 cites W1142864331 @default.
• W2789766211 cites W1143851354 @default.
• W2789766211 cites W1469763241 @default.
• W2789766211 cites W1511740446 @default.
• W2789766211 cites W1606006491 @default.
• W2789766211 cites W1619853111 @default.
• W2789766211 cites W1730677387 @default.
• W2789766211 cites W1797102164 @default.
• W2789766211 cites W1828269311 @default.
• W2789766211 cites W1832262637 @default.
• W2789766211 cites W1849626795 @default.
• W2789766211 cites W1897589155 @default.
• W2789766211 cites W1939889341 @default.
• W2789766211 cites W1966761076 @default.
• W2789766211 cites W1970473240 @default.
• W2789766211 cites W1973138133 @default.
• W2789766211 cites W1975899151 @default.
• W2789766211 cites W1986717573 @default.
• W2789766211 cites W1987397557 @default.
• W2789766211 cites W1993645422 @default.
• W2789766211 cites W2004173167 @default.
• W2789766211 cites W2012491213 @default.
• W2789766211 cites W2014756302 @default.
• W2789766211 cites W2015036539 @default.
• W2789766211 cites W2017578524 @default.
• W2789766211 cites W2019873695 @default.
• W2789766211 cites W2020887697 @default.
• W2789766211 cites W2029596277 @default.
• W2789766211 cites W2033368074 @default.
• W2789766211 cites W2034108399 @default.
• W2789766211 cites W2042314805 @default.
• W2789766211 cites W2049309750 @default.
• W2789766211 cites W2052325603 @default.
• W2789766211 cites W2065254519 @default.
• W2789766211 cites W2066555189 @default.
• W2789766211 cites W2069814630 @default.
• W2789766211 cites W2069894028 @default.
• W2789766211 cites W2071318481 @default.
• W2789766211 cites W2078771842 @default.
• W2789766211 cites W2084494997 @default.
• W2789766211 cites W2094379124 @default.
• W2789766211 cites W2098277878 @default.
• W2789766211 cites W2100771148 @default.
• W2789766211 cites W2103770453 @default.
• W2789766211 cites W2105006060 @default.
• W2789766211 cites W2106971401 @default.
• W2789766211 cites W2110374888 @default.
• W2789766211 cites W2113803126 @default.
• W2789766211 cites W2115432859 @default.
• W2789766211 cites W2117421244 @default.
• W2789766211 cites W2120195741 @default.
• W2789766211 cites W2123194540 @default.
• W2789766211 cites W2129032286 @default.
• W2789766211 cites W2129908815 @default.
• W2789766211 cites W2130743173 @default.
• W2789766211 cites W2131104106 @default.
• W2789766211 cites W2133470905 @default.
• W2789766211 cites W2133659563 @default.
• W2789766211 cites W2138033133 @default.
• W2789766211 cites W2141041915 @default.
• W2789766211 cites W2142150505 @default.
• W2789766211 cites W2144816990 @default.
• W2789766211 cites W2146792003 @default.
• W2789766211 cites W2153253565 @default.
• W2789766211 cites W2153603424 @default.
• W2789766211 cites W2154626303 @default.
• W2789766211 cites W2168257805 @default.
• W2789766211 cites W2172010489 @default.
• W2789766211 cites W2205794177 @default.
• W2789766211 cites W2214092289 @default.
• W2789766211 cites W2236015617 @default.
• W2789766211 cites W2247835184 @default.
• W2789766211 cites W2298567496 @default.
• W2789766211 cites W2302440598 @default.
• W2789766211 cites W2320983896 @default.
• W2789766211 cites W2332949234 @default.
• W2789766211 cites W2343013766 @default.
• W2789766211 cites W2509350884 @default.
• W2789766211 cites W2511159179 @default.
• W2789766211 cites W2559601109 @default.
• W2789766211 cites W2586432482 @default.
• W2789766211 cites W2767090585 @default.
• W2789766211 cites W2793468531 @default.

• next