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- W2789775699 abstract "See related article, p 31 See related article, p 31 Organization of regional perinatal services according to the capabilities of each facility and coordination among facilities has been considered optimal maternal and neonatal care since the publication of the first version of Toward Improving the Outcome of Pregnancy in 1976.1Committee on Perinatal Health Toward improving the outcome of pregnancy. Recommendations for the regional development of maternal and perinatal services. March of Dimes, White Plains (NY)1976Google Scholar The view that the outcome of preterm or ill newborns is better when their care is appropriate to their gestational age, complexity, or severity of illness is supported by the American Academy of Pediatrics through a policy statement defining levels of neonatal care; this is promoted jointly with the American College of Obstetricians and Gynecologists in Guidelines for Perinatal Care.2American Academy of Pediatrics Committee on Fetus and Newborn Levels of neonatal care.Pediatrics. 2012; 130: 587-597Crossref PubMed Scopus (342) Google Scholar, 3Sarah J. Kilpatrick S.J. Papile L.A. Guidelines for perinatal care. 8th ed. American Academy of Pediatrics, Elk Grove Village (IL)2017Google Scholar These publications define characteristics of 4 levels of care, from the most basic Level I newborn nursery to a Level IV center, often located at a children's hospital and capable of caring for the most fragile and medically complex newborns. Strong evidence from a systematic review of 41 studies published over 34 years shows that risk-appropriate care improves survival of infants born at very low birth weight (VLBW).4Lasswell S.M. Barfield W.D. Rochat R.W. Blackmon L. Perinatal regionalization for very low-birth-weight and very preterm infants.JAMA. 2010; 304: 992-1000Crossref PubMed Scopus (221) Google Scholar This report shows that infants born at VLBW outside a hospital with a tertiary newborn intensive care unit (NICU) have a 60% risk of increased predischarge mortality compared with those born in one with a tertiary NICU. For infants born at extremely low birth weight, ie, those born weighing <1000 g, the risk of death is 80% greater. This increased risk of mortality did not change over the period covered in the review. More recent data suggest that risk-appropriate care also reduces morbidity and outcome of morbid conditions. In reports from the California Perinatal Quality Care Collaborative, the rate of bronchopulmonary dysplasia or death is greater for infants born preterm who are cared for in hospitals with Level II than with Level IV NICUs and the mortality associated with necrotizing enterocolitis is lowest for infants cared for in centers with high-level, high-volume NICUs.5Lapcharoensap W. Gage S.C. Kan P. Profit J. Shaw G.M. Gould J.B. et al.Hospital variation and risk factors for bronchopulmonary dysplasia in a population-based cohort.JAMA Pediatr. 2015; 169: e143676Crossref PubMed Scopus (88) Google Scholar, 6Kastenberg Z.J. Lee H.C. Profit J. Gould J.B. Sylvester K.G. Effect of deregionalized care on mortality in very low-birth-weight infants with necrotizing enterocolitis.JAMA Pediatr. 2015; 169: 26-32Crossref PubMed Scopus (53) Google Scholar In another study that used data from 3 states, the risk of death or severe intraventricular hemorrhage and of death or necrotizing enterocolitis was greater in infants of VLBW born at a facility with a lower-level or lower-volume NICU compared with those born where there was a greater-level or greater-volume NICU.7Jensen E.A. Lorch S.A. Effects of birth hospital's neonatal intensive care unit level and annual volume of very low-birth-weight infant deliveries on morbidity and mortality.JAMA Pediatr. 2015; 169: e151906Crossref PubMed Scopus (52) Google Scholar In addition, mortality, more ventilator days, and longer length of hospitalization were lower in infants with gastroschisis cared for in the highest-level centers compared with those born in facilities with lower-level NICUs.8Apfeld J.C. Kasterberg Z.I. Sylvester K.G. Lee H.C. The effect of level of care on gastroschisis outcomes.J Pediatr. 2017; 190: 79-84Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar In this volume of The Journal, Amer et al report that outborn infants born preterm at <29 weeks of gestation were more likely to have the composite of death or adverse neurodevelopmental outcomes than those born in NICUs within the Canadian Neonatal Network.9Amer R. Moddemann D. Seshia M. Alvaro R. Synnes A. Lee K.-S. et al.Neurodevelopmental outcomes of infants born at <29 weeks of gestation admitted to Canadian neonatal intensive care units based on location of birth.J Pediatr. 2018; 196: 31-37Abstract Full Text Full Text PDF PubMed Scopus (41) Google Scholar Using data from 28 Network centers, the authors studied nearly 3000 infants, of whom 16% were outborn. Similar to previous findings, the rates of death, severe brain injury, and grade III or IV intraventricular hemorrhage were greater in the outborn infants. The increased rates of brain injury likely set the stage for their observation that outborn infants also were more likely to have cerebral palsy. Because their study was retrospective, a number of questions remain. To help interpret the data, as the authors acknowledge, it would be important to know why infants were delivered outside of a tertiary center. Was this maternal or obstetric choice, or was the delivery too urgent or imminent for maternal transfer? The latter situation might explain the lower rate of antenatal steroid use and the shorter duration of ruptured membranes they found in the outborn infants. The loss to follow-up was also almost 50% greater in the outborn than inborn infants. Did those infants who were not evaluated have worse or better outcomes than those who were? Although the odds of the combination of death and either severe neurodevelopmental impairment or any neurodevelopmental impairment were greater among the outborn cohort (OR 1.6 [1.25-2.24] and 1.61 [1.20-2.16], respectively), among survivors, the odds of either severe neurodevelopmental impairment or any neurodevelopmental impairment were similar (OR 1.21 [0.82-1.81] and 1.36 [0.98-3.29], respectively). The finding of similar outcomes in survivors is comparable with those noted in a study assessing the risk of neurodevelopmental impairment at 2-3 years' corrected age for outborn infants born extremely preterm in an Australian regional network.10Mahoney K. Bajuk B. Oei J. Lui K. Abdel-Latif M.E. NICUS NetworkRisk of neurodevelopmental impairment for outborn extremely preterm infants in an Australian regional network.J Matern Fetal Neonatal Med. 2017; 30: 96-102Crossref PubMed Scopus (10) Google Scholar In that study, the primary outcome of moderate-to-severe functional disability, defined as developmental delay (>2 SD below the mean for adjusted age determined by the Griffins Mental Developmental Scales or Bayley Scales of Infant Development-II), cerebral palsy (unable to walk without aids), bilateral blindness (visual acuity <6/60 in better eye), or bilateral deafness (requiring bilateral hearing aids or unilateral/bilateral cochlear implants) was not significantly different between outborn and inborn infants. Unlike the present study, the Australian study did not find an increased risk of cerebral palsy in the outborn cohort. Use of different criteria to diagnose cerebral palsy most likely explains the difference in the risk of cerebral palsy between the 2 studies. The study by Amer et al includes infants with any evidence of cerebral palsy (Gross Motor Classification System Score >1), whereas the Australian study included only children who were unable to walk without aids (Gross Motor Classification System Score >2). Published follow-up studies typically include the latter definition as a criterion for neurodevelopmental impairment. Sadly, we know that in the US, 25% of infants born at VLBW are delivered in hospitals that do not have tertiary NICUs.11Healthy People 2020 Maternal, Infant, and Child Health Measure 33.https://www.healthypeople.gov/node/4892/data_detailsDate accessed: January 23, 2018Google Scholar In addition, a review of current state policies found that less than one half of states have policies in various stages of revision and adoption, and the remainder have no identifiable policy language on regionalized perinatal care.12Kroelinger C.D. Okoroh E.M. Goodman D.A. Lasswell S.M. Barfield W.D. Comparison of state risk-appropriate care policies with 2012 AAP policy statement.J Perinatol. 2017; (in press)Crossref PubMed Scopus (13) Google Scholar The affirmation of increased mortality and potentially poorer neurodevelopmental outcomes in outborn infants born preterm suggests the perinatal community has much more work to do to ensure risk-appropriate care for all newborns. Neurodevelopmental Outcomes of Infants Born at <29 Weeks of Gestation Admitted to Canadian Neonatal Intensive Care Units Based on Location of BirthThe Journal of PediatricsVol. 196PreviewTo compare mortality and neurodevelopmental outcomes of outborn and inborn preterm infants born at <29 weeks of gestation admitted to Canadian neonatal intensive care units (NICUs). Full-Text PDF" @default.
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- W2789775699 title "Potential Impact on Development: More Evidence for Risk-Appropriate Neonatal Care" @default.
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