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• W2789845276 abstract "Five years ago, we introduced the thrift hypothesis of dopamine, suggesting that the primary role of dopamine in adaptive behavior is regulating behavioral energy expenditure to match the prevailing economic conditions of the environment. Here we elaborate that hypothesis with several new ideas. First, we introduce the concept of affordability, suggesting that costs must necessarily be evaluated with respect to the availability of resources to the organism, which computes a value not only for the potential reward opportunity, but also the value of resources expended. Placing both costs and benefits within the context of the larger economy in which the animal is functioning requires consideration of the different timescales against which to compute resource availability, or average reward rate. Appropriate windows of computation for tracking resources requires corresponding neural substrates that operate on these different timescales. In discussing temporal patterns of dopamine signaling, we focus on a neglected form of dopamine plasticity and adaptation, changes in the physical substrate of the dopamine system itself, such as up- and down-regulation of receptors or release probability. We argue that changes in the dopamine substrate itself fundamentally alter its computational function, which we propose mediates adaptations to longer temporal horizons and economic conditions. In developing our hypothesis, we focus on dopamine D2 (D2R) receptors, arguing that D2R implements a form of 'cost control' in response to the environmental economy, serving as the 'brain's comptroller.' We propose that the balance between the direct and indirect pathway, regulated by relative expression of D1 and D2 dopamine receptors, implements affordability. Finally, as we review data, we discuss limitations in current approaches that impede fully investigating the proposed hypothesis and highlight alternative, more semi-naturalistic strategies more conducive to neuroeconomic investigations on the role of dopamine in adaptive behavior." @default.
• W2789845276 created "2018-03-29" @default.
• W2789845276 creator A5014687196 @default.
• W2789845276 creator A5018967002 @default.
• W2789845276 date "2018-02-13" @default.
• W2789845276 modified "2023-10-14" @default.
• W2789845276 title "To Do or Not to Do: Dopamine, Affordability and the Economics of Opportunity" @default.
• W2789845276 cites W1076752630 @default.
• W2789845276 cites W122691953 @default.
• W2789845276 cites W1480115940 @default.
• W2789845276 cites W1509264826 @default.
• W2789845276 cites W1529770635 @default.
• W2789845276 cites W1540102462 @default.
• W2789845276 cites W1549657738 @default.
• W2789845276 cites W1573319238 @default.
• W2789845276 cites W1604110764 @default.
• W2789845276 cites W1607531583 @default.
• W2789845276 cites W1612489662 @default.
• W2789845276 cites W1632957190 @default.
• W2789845276 cites W1633847368 @default.
• W2789845276 cites W1642699591 @default.
• W2789845276 cites W1647678806 @default.
• W2789845276 cites W1663689753 @default.
• W2789845276 cites W1806613378 @default.
• W2789845276 cites W1851407835 @default.
• W2789845276 cites W1853541416 @default.
• W2789845276 cites W1854755157 @default.
• W2789845276 cites W1913013241 @default.
• W2789845276 cites W1915088265 @default.
• W2789845276 cites W1921515037 @default.
• W2789845276 cites W192505479 @default.
• W2789845276 cites W1949404224 @default.
• W2789845276 cites W1965723380 @default.
• W2789845276 cites W1966148872 @default.
• W2789845276 cites W1966443363 @default.
• W2789845276 cites W1966891940 @default.
• W2789845276 cites W1967039863 @default.
• W2789845276 cites W1967182648 @default.
• W2789845276 cites W1967763783 @default.
• W2789845276 cites W1968966047 @default.
• W2789845276 cites W1969089145 @default.
• W2789845276 cites W1970124769 @default.
• W2789845276 cites W1970697913 @default.
• W2789845276 cites W1971797700 @default.
• W2789845276 cites W1971999279 @default.
• W2789845276 cites W1972539713 @default.
• W2789845276 cites W1972738529 @default.
• W2789845276 cites W1973986591 @default.
• W2789845276 cites W1974756058 @default.
• W2789845276 cites W1976284302 @default.
• W2789845276 cites W1976423224 @default.
• W2789845276 cites W1976555581 @default.
• W2789845276 cites W1977915489 @default.
• W2789845276 cites W1977927688 @default.
• W2789845276 cites W1978674818 @default.
• W2789845276 cites W1980618099 @default.
• W2789845276 cites W1980747731 @default.
• W2789845276 cites W1981654563 @default.
• W2789845276 cites W1981719302 @default.
• W2789845276 cites W1982223225 @default.
• W2789845276 cites W1982670892 @default.
• W2789845276 cites W1982827121 @default.
• W2789845276 cites W1983372194 @default.
• W2789845276 cites W1983812459 @default.
• W2789845276 cites W1983896836 @default.
• W2789845276 cites W1984132513 @default.
• W2789845276 cites W1986185847 @default.
• W2789845276 cites W1987953899 @default.
• W2789845276 cites W1988112870 @default.
• W2789845276 cites W1989637315 @default.
• W2789845276 cites W1989912928 @default.
• W2789845276 cites W1990556558 @default.
• W2789845276 cites W1992925097 @default.
• W2789845276 cites W1993833941 @default.
• W2789845276 cites W1994693675 @default.
• W2789845276 cites W1996061528 @default.
• W2789845276 cites W1997089027 @default.
• W2789845276 cites W1998033984 @default.
• W2789845276 cites W1999611081 @default.
• W2789845276 cites W1999657943 @default.
• W2789845276 cites W2000385214 @default.
• W2789845276 cites W2001113734 @default.
• W2789845276 cites W2001195560 @default.
• W2789845276 cites W2001980298 @default.
• W2789845276 cites W2002630309 @default.
• W2789845276 cites W2002851360 @default.
• W2789845276 cites W2003041124 @default.
• W2789845276 cites W2003168086 @default.
• W2789845276 cites W2003413351 @default.
• W2789845276 cites W2003982930 @default.
• W2789845276 cites W2004415631 @default.
• W2789845276 cites W2004416309 @default.
• W2789845276 cites W2005269174 @default.
• W2789845276 cites W2008762508 @default.
• W2789845276 cites W2008857744 @default.
• W2789845276 cites W2008891545 @default.
• W2789845276 cites W2009309616 @default.
• W2789845276 cites W2010405191 @default.
• W2789845276 cites W2011718822 @default.
• W2789845276 cites W2012806030 @default.

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