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- W2789856472 endingPage "135" @default.
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- W2789856472 abstract "The acoustic startle reflex (ASR) is subject to substantial variability. This inherent variability consequently shapes the conclusions drawn from gap-induced prepulse inhibition of the acoustic startle reflex (GPIAS) assessments. Recent studies have cast doubt as to the efficacy of this methodology as it pertains to tinnitus assessment, partially, due to variability in and between data sets. The goal of this study was to examine the variance associated with several common data collection variables and data analyses with the aim to improve GPIAS reliability. To study this the GPIAS tests were conducted in adult male and female CBA/CaJ mice. Factors such as inter-trial interval, circadian rhythm, sex differences, and sensory adaptation were each evaluated. We then examined various data analysis factors which influence GPIAS assessment. Gap-induced facilitation, data processing options, and assessments of tinnitus were studied. We found that the startle reflex is highly variable in CBA/CaJ mice, but this can be minimized by certain data collection factors. We also found that careful consideration of temporal fluctuations of the ASR and controlling for facilitation can lead to more accurate GPIAS results. This study provides a guide for reducing variance in the GPIAS methodology - thereby improving the diagnostic power of the test." @default.
- W2789856472 created "2018-03-29" @default.
- W2789856472 creator A5021168641 @default.
- W2789856472 creator A5026649876 @default.
- W2789856472 creator A5044692832 @default.
- W2789856472 creator A5058697690 @default.
- W2789856472 creator A5083480601 @default.
- W2789856472 date "2018-06-01" @default.
- W2789856472 modified "2023-10-15" @default.
- W2789856472 title "Addressing variability in the acoustic startle reflex for accurate gap detection assessment" @default.
- W2789856472 cites W1505441000 @default.
- W2789856472 cites W1923775948 @default.
- W2789856472 cites W1963912375 @default.
- W2789856472 cites W1967087682 @default.
- W2789856472 cites W1970137351 @default.
- W2789856472 cites W1972407096 @default.
- W2789856472 cites W1973085419 @default.
- W2789856472 cites W1973138778 @default.
- W2789856472 cites W1974528497 @default.
- W2789856472 cites W1974748631 @default.
- W2789856472 cites W1975759745 @default.
- W2789856472 cites W1982126126 @default.
- W2789856472 cites W1982458746 @default.
- W2789856472 cites W1982957904 @default.
- W2789856472 cites W1983262456 @default.
- W2789856472 cites W1984305433 @default.
- W2789856472 cites W1989128230 @default.
- W2789856472 cites W1989629454 @default.
- W2789856472 cites W1990414759 @default.
- W2789856472 cites W1993519530 @default.
- W2789856472 cites W1993829642 @default.
- W2789856472 cites W1994667451 @default.
- W2789856472 cites W2001529605 @default.
- W2789856472 cites W2002001750 @default.
- W2789856472 cites W2002293846 @default.
- W2789856472 cites W2003158999 @default.
- W2789856472 cites W2004691691 @default.
- W2789856472 cites W2004820003 @default.
- W2789856472 cites W2004966500 @default.
- W2789856472 cites W2005749656 @default.
- W2789856472 cites W2006082592 @default.
- W2789856472 cites W2006745426 @default.
- W2789856472 cites W2008941500 @default.
- W2789856472 cites W2008973241 @default.
- W2789856472 cites W2019764069 @default.
- W2789856472 cites W2025480171 @default.
- W2789856472 cites W2026634685 @default.
- W2789856472 cites W2027822604 @default.
- W2789856472 cites W2028147063 @default.
- W2789856472 cites W2029157004 @default.
- W2789856472 cites W2029340358 @default.
- W2789856472 cites W2033774250 @default.
- W2789856472 cites W2034101922 @default.
- W2789856472 cites W2035859589 @default.
- W2789856472 cites W2044510137 @default.
- W2789856472 cites W2047187993 @default.
- W2789856472 cites W2048684532 @default.
- W2789856472 cites W2049266983 @default.
- W2789856472 cites W2054030359 @default.
- W2789856472 cites W2054379176 @default.
- W2789856472 cites W2055214163 @default.
- W2789856472 cites W2055997117 @default.
- W2789856472 cites W2056271635 @default.
- W2789856472 cites W2058374379 @default.
- W2789856472 cites W2059908764 @default.
- W2789856472 cites W2060236853 @default.
- W2789856472 cites W2061072639 @default.
- W2789856472 cites W2065097399 @default.
- W2789856472 cites W2066692673 @default.
- W2789856472 cites W2073695504 @default.
- W2789856472 cites W2074132525 @default.
- W2789856472 cites W2074477628 @default.
- W2789856472 cites W2075190732 @default.
- W2789856472 cites W2076287390 @default.
- W2789856472 cites W2079649308 @default.
- W2789856472 cites W2080835373 @default.
- W2789856472 cites W2080942999 @default.
- W2789856472 cites W2081689319 @default.
- W2789856472 cites W2084479888 @default.
- W2789856472 cites W2086364410 @default.
- W2789856472 cites W2089377155 @default.
- W2789856472 cites W2091869490 @default.
- W2789856472 cites W2096790979 @default.
- W2789856472 cites W2103551437 @default.
- W2789856472 cites W2139500746 @default.
- W2789856472 cites W2141698450 @default.
- W2789856472 cites W2159648246 @default.
- W2789856472 cites W2160351963 @default.
- W2789856472 cites W2167158741 @default.
- W2789856472 cites W2167964159 @default.
- W2789856472 cites W233156525 @default.
- W2789856472 cites W2332692642 @default.
- W2789856472 cites W2439789739 @default.
- W2789856472 cites W2460054080 @default.
- W2789856472 cites W2515387058 @default.
- W2789856472 cites W2532700455 @default.
- W2789856472 cites W2769368388 @default.
- W2789856472 cites W4234762367 @default.