Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789860708> ?p ?o ?g. }
- W2789860708 endingPage "540" @default.
- W2789860708 startingPage "531" @default.
- W2789860708 abstract "Abstract Background: The “meeting-in-the-middle” (MITM) is a principle to identify exposure biomarkers that are also predictors of disease. The MITM statistical framework was applied in a nested case–control study of hepatocellular carcinoma (HCC) within European Prospective Investigation into Cancer and Nutrition (EPIC), where healthy lifestyle index (HLI) variables were related to targeted serum metabolites. Methods: Lifestyle and targeted metabolomic data were available from 147 incident HCC cases and 147 matched controls. Partial least squares analysis related 7 lifestyle variables from a modified HLI to a set of 132 serum-measured metabolites and a liver function score. Mediation analysis evaluated whether metabolic profiles mediated the relationship between each lifestyle exposure and HCC risk. Results: Exposure-related metabolic signatures were identified. Particularly, the body mass index (BMI)-associated metabolic component was positively related to glutamic acid, tyrosine, PC aaC38:3, and liver function score and negatively to lysoPC aC17:0 and aC18:2. The lifetime alcohol-specific signature had negative loadings on sphingomyelins (SM C16:1, C18:1, SM(OH) C14:1, C16:1 and C22:2). Both exposures were associated with increased HCC with total effects (TE) = 1.23 (95% confidence interval = 0.93–1.62) and 1.40 (1.14–1.72), respectively, for BMI and alcohol consumption. Both metabolic signatures mediated the association between BMI and lifetime alcohol consumption and HCC with natural indirect effects, respectively, equal to 1.56 (1.24–1.96) and 1.09 (1.03–1.15), accounting for a proportion mediated of 100% and 24%. Conclusions: In a refined MITM framework, relevant metabolic signatures were identified as mediators in the relationship between lifestyle exposures and HCC risk. Impact: The understanding of the biological basis for the relationship between modifiable exposures and cancer would pave avenues for clinical and public health interventions on metabolic mediators. Cancer Epidemiol Biomarkers Prev; 27(5); 531–40. ©2018 AACR." @default.
- W2789860708 created "2018-03-29" @default.
- W2789860708 creator A5000739842 @default.
- W2789860708 creator A5000754469 @default.
- W2789860708 creator A5011831367 @default.
- W2789860708 creator A5014315256 @default.
- W2789860708 creator A5020009666 @default.
- W2789860708 creator A5021077470 @default.
- W2789860708 creator A5024087229 @default.
- W2789860708 creator A5031594786 @default.
- W2789860708 creator A5031874687 @default.
- W2789860708 creator A5034156847 @default.
- W2789860708 creator A5034534124 @default.
- W2789860708 creator A5039389769 @default.
- W2789860708 creator A5039664461 @default.
- W2789860708 creator A5040098515 @default.
- W2789860708 creator A5048179797 @default.
- W2789860708 creator A5050752543 @default.
- W2789860708 creator A5054649146 @default.
- W2789860708 creator A5060396702 @default.
- W2789860708 creator A5067228080 @default.
- W2789860708 creator A5067980710 @default.
- W2789860708 creator A5074815814 @default.
- W2789860708 creator A5085715708 @default.
- W2789860708 date "2018-04-30" @default.
- W2789860708 modified "2023-10-14" @default.
- W2789860708 title "Are Metabolic Signatures Mediating the Relationship between Lifestyle Factors and Hepatocellular Carcinoma Risk? Results from a Nested Case–Control Study in EPIC" @default.
- W2789860708 cites W1052281432 @default.
- W2789860708 cites W1562774109 @default.
- W2789860708 cites W1585343692 @default.
- W2789860708 cites W1765294315 @default.
- W2789860708 cites W1836142841 @default.
- W2789860708 cites W1852948073 @default.
- W2789860708 cites W1916430996 @default.
- W2789860708 cites W1972137183 @default.
- W2789860708 cites W1973349126 @default.
- W2789860708 cites W1974580919 @default.
- W2789860708 cites W1979723442 @default.
- W2789860708 cites W1979918427 @default.
- W2789860708 cites W1982153589 @default.
- W2789860708 cites W1987839661 @default.
- W2789860708 cites W1988501594 @default.
- W2789860708 cites W1994573648 @default.
- W2789860708 cites W1995112204 @default.
- W2789860708 cites W1999928502 @default.
- W2789860708 cites W2005441291 @default.
- W2789860708 cites W2008017193 @default.
- W2789860708 cites W2013596666 @default.
- W2789860708 cites W2014895573 @default.
- W2789860708 cites W2015243323 @default.
- W2789860708 cites W2025885388 @default.
- W2789860708 cites W2027444853 @default.
- W2789860708 cites W2036763367 @default.
- W2789860708 cites W2037659103 @default.
- W2789860708 cites W2041761779 @default.
- W2789860708 cites W2042418561 @default.
- W2789860708 cites W2044681673 @default.
- W2789860708 cites W2050318245 @default.
- W2789860708 cites W2052408325 @default.
- W2789860708 cites W2057858725 @default.
- W2789860708 cites W2058189643 @default.
- W2789860708 cites W2064132909 @default.
- W2789860708 cites W2068357612 @default.
- W2789860708 cites W2073270896 @default.
- W2789860708 cites W2075341416 @default.
- W2789860708 cites W2078281362 @default.
- W2789860708 cites W2084701241 @default.
- W2789860708 cites W2089569798 @default.
- W2789860708 cites W2092842024 @default.
- W2789860708 cites W2095155152 @default.
- W2789860708 cites W2097494822 @default.
- W2789860708 cites W2104132854 @default.
- W2789860708 cites W2109219853 @default.
- W2789860708 cites W2113468195 @default.
- W2789860708 cites W2118413672 @default.
- W2789860708 cites W2118608422 @default.
- W2789860708 cites W2123055140 @default.
- W2789860708 cites W2123098050 @default.
- W2789860708 cites W2128936257 @default.
- W2789860708 cites W2132617827 @default.
- W2789860708 cites W2138649409 @default.
- W2789860708 cites W2138695073 @default.
- W2789860708 cites W2150352109 @default.
- W2789860708 cites W2150726616 @default.
- W2789860708 cites W2155519151 @default.
- W2789860708 cites W2157043395 @default.
- W2789860708 cites W2158958532 @default.
- W2789860708 cites W2159486148 @default.
- W2789860708 cites W2166312347 @default.
- W2789860708 cites W2167418292 @default.
- W2789860708 cites W2171538199 @default.
- W2789860708 cites W2177838855 @default.
- W2789860708 cites W2213448039 @default.
- W2789860708 cites W2252854900 @default.
- W2789860708 cites W2256739350 @default.
- W2789860708 cites W2275653843 @default.
- W2789860708 cites W2283733219 @default.
- W2789860708 cites W2292757746 @default.