Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789871221> ?p ?o ?g. }
- W2789871221 abstract "Keratoconus is the primary cause of corneal transplantation in young adults worldwide. Riboflavin/UV‐A corneal cross‐linking may effectively halt the progression of keratoconus if an adequate amount of riboflavin enriches the corneal stroma and is photo‐oxidated by UV‐A light for generating additional cross‐linking bonds between stromal proteins and strengthening the biomechanics of the weakened cornea. Here we reported an UV‐A theranostic prototype device for performing corneal cross‐linking with the ability to assess corneal intrastromal concentration of riboflavin and to estimate treatment efficacy in real time. Seventeen human donor corneas were treated according to the conventional riboflavin/UV‐A corneal cross‐linking protocol. Ten of these tissues were probed with atomic force microscopy in order to correlate the intrastromal riboflavin concentration recorded during treatment with the increase in elastic modulus of the anterior corneal stroma. The intrastromal riboflavin concentration and its consumption during UV‐A irradiation of the cornea were highly significantly correlated ( R = 0.79; P = .03) with the treatment‐induced stromal stiffening effect. The present study showed an ophthalmic device that provided an innovative, non‐invasive, real‐time monitoring solution for estimating corneal cross‐linking treatment efficacy on a personalized basis." @default.
- W2789871221 created "2018-03-29" @default.
- W2789871221 creator A5013600020 @default.
- W2789871221 creator A5022277501 @default.
- W2789871221 creator A5027763604 @default.
- W2789871221 creator A5038460182 @default.
- W2789871221 creator A5044602168 @default.
- W2789871221 creator A5051419867 @default.
- W2789871221 creator A5062096714 @default.
- W2789871221 date "2018-04-10" @default.
- W2789871221 modified "2023-10-18" @default.
- W2789871221 title "Non-invasive optical method for real-time assessment of intracorneal riboflavin concentration and efficacy of corneal cross-linking" @default.
- W2789871221 cites W1251273715 @default.
- W2789871221 cites W1562250910 @default.
- W2789871221 cites W1571960601 @default.
- W2789871221 cites W1572654736 @default.
- W2789871221 cites W1914690349 @default.
- W2789871221 cites W1915025757 @default.
- W2789871221 cites W1964057235 @default.
- W2789871221 cites W1966683531 @default.
- W2789871221 cites W1983311424 @default.
- W2789871221 cites W1984288164 @default.
- W2789871221 cites W1992915174 @default.
- W2789871221 cites W2001530049 @default.
- W2789871221 cites W2002369769 @default.
- W2789871221 cites W2005469821 @default.
- W2789871221 cites W2011906486 @default.
- W2789871221 cites W2013122840 @default.
- W2789871221 cites W2016064264 @default.
- W2789871221 cites W2035770067 @default.
- W2789871221 cites W2053193157 @default.
- W2789871221 cites W2056977603 @default.
- W2789871221 cites W2065132583 @default.
- W2789871221 cites W2073153326 @default.
- W2789871221 cites W2074613678 @default.
- W2789871221 cites W2075503866 @default.
- W2789871221 cites W2093781936 @default.
- W2789871221 cites W2099340856 @default.
- W2789871221 cites W2099905459 @default.
- W2789871221 cites W2103450125 @default.
- W2789871221 cites W2111055787 @default.
- W2789871221 cites W2131247133 @default.
- W2789871221 cites W2138050052 @default.
- W2789871221 cites W2142817956 @default.
- W2789871221 cites W2150903279 @default.
- W2789871221 cites W2151387045 @default.
- W2789871221 cites W2155644024 @default.
- W2789871221 cites W2158105522 @default.
- W2789871221 cites W2167005887 @default.
- W2789871221 cites W2208946414 @default.
- W2789871221 cites W2294312478 @default.
- W2789871221 cites W4211119105 @default.
- W2789871221 cites W1703423401 @default.
- W2789871221 doi "https://doi.org/10.1002/jbio.201800028" @default.
- W2789871221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29451741" @default.
- W2789871221 hasPublicationYear "2018" @default.
- W2789871221 type Work @default.
- W2789871221 sameAs 2789871221 @default.
- W2789871221 citedByCount "11" @default.
- W2789871221 countsByYear W27898712212018 @default.
- W2789871221 countsByYear W27898712212019 @default.
- W2789871221 countsByYear W27898712212020 @default.
- W2789871221 countsByYear W27898712212021 @default.
- W2789871221 countsByYear W27898712212022 @default.
- W2789871221 countsByYear W27898712212023 @default.
- W2789871221 crossrefType "journal-article" @default.
- W2789871221 hasAuthorship W2789871221A5013600020 @default.
- W2789871221 hasAuthorship W2789871221A5022277501 @default.
- W2789871221 hasAuthorship W2789871221A5027763604 @default.
- W2789871221 hasAuthorship W2789871221A5038460182 @default.
- W2789871221 hasAuthorship W2789871221A5044602168 @default.
- W2789871221 hasAuthorship W2789871221A5051419867 @default.
- W2789871221 hasAuthorship W2789871221A5062096714 @default.
- W2789871221 hasConcept C118487528 @default.
- W2789871221 hasConcept C142724271 @default.
- W2789871221 hasConcept C16930146 @default.
- W2789871221 hasConcept C185592680 @default.
- W2789871221 hasConcept C203014093 @default.
- W2789871221 hasConcept C204232928 @default.
- W2789871221 hasConcept C2776155809 @default.
- W2789871221 hasConcept C2776882836 @default.
- W2789871221 hasConcept C2778918178 @default.
- W2789871221 hasConcept C2779247740 @default.
- W2789871221 hasConcept C2780686511 @default.
- W2789871221 hasConcept C52124034 @default.
- W2789871221 hasConcept C55493867 @default.
- W2789871221 hasConcept C71924100 @default.
- W2789871221 hasConceptScore W2789871221C118487528 @default.
- W2789871221 hasConceptScore W2789871221C142724271 @default.
- W2789871221 hasConceptScore W2789871221C16930146 @default.
- W2789871221 hasConceptScore W2789871221C185592680 @default.
- W2789871221 hasConceptScore W2789871221C203014093 @default.
- W2789871221 hasConceptScore W2789871221C204232928 @default.
- W2789871221 hasConceptScore W2789871221C2776155809 @default.
- W2789871221 hasConceptScore W2789871221C2776882836 @default.
- W2789871221 hasConceptScore W2789871221C2778918178 @default.
- W2789871221 hasConceptScore W2789871221C2779247740 @default.
- W2789871221 hasConceptScore W2789871221C2780686511 @default.
- W2789871221 hasConceptScore W2789871221C52124034 @default.
- W2789871221 hasConceptScore W2789871221C55493867 @default.