Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789871513> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2789871513 abstract "Nowadays, a reduced initial daily dose of tacrolimus (Tac) (0.1-0.15 mg/kg) is recommended for the majority of kidney transplant recipients (KTRs). The aim of the study was to analyze the safety of such a regimen, including the risk of first inadequately low Tac blood level, acute rejection (AR) occurrence, or early graft dysfunction.In 2011, we introduced a modified (0.1-0.15 mg/kg/d) initial Tac dosing regimen in older (>55 years) and/or overweight KTRs. To assure the safety of this protocol, we monitored the risk of inadequately low blood Tac level (<6 ng/mL) and incidence of AR or delayed graft function (DGF). The historical cohort with the higher Tac dosing regimen (0.2 mg/kg/d, n = 208) served as a control group.The mean Tac daily dose in 78 KTRs (group with reduced dosing) was 0.133 (95% confidence interval [CI], 0.130-0.136) mg/kg and was significantly lower than the standard, previously prescribed dose of 0.195 (95% CI, 0.194-0.197) mg/kg. Of note, induction therapy was employed twice more often in the reduced Tac dosing group. The dose reduction resulted in a slight, nonsignificant decrease in first Tac trough level. The percentages of patients with first Tac troughs <6 ng/mL (5.1% vs 4.8%), AR (6.4% vs 5.8%), and DGF (25.6% vs 31.2%) were similar in the reduced and standard dosing groups.The currently recommended reduction in Tac initial dosing does not increase the risk of inadequate immunosuppression and does not affect the early graft function. Regardless of Tac dose reduction, there is still a substantial risk of Tac overdosing in older or overweight KTRs." @default.
- W2789871513 created "2018-03-29" @default.
- W2789871513 creator A5044605455 @default.
- W2789871513 creator A5045517198 @default.
- W2789871513 creator A5048565684 @default.
- W2789871513 creator A5083292468 @default.
- W2789871513 creator A5087571503 @default.
- W2789871513 date "2018-07-01" @default.
- W2789871513 modified "2023-10-14" @default.
- W2789871513 title "No Significant Influence of Reduced Initial Tacrolimus Dose on Risk of Underdosing and Early Graft Function in Older and Overweight Kidney Transplant Recipients" @default.
- W2789871513 cites W1501247583 @default.
- W2789871513 cites W1585188628 @default.
- W2789871513 cites W1594894166 @default.
- W2789871513 cites W1891520818 @default.
- W2789871513 cites W1964466177 @default.
- W2789871513 cites W1980412428 @default.
- W2789871513 cites W1980669038 @default.
- W2789871513 cites W1997252361 @default.
- W2789871513 cites W2000230167 @default.
- W2789871513 cites W2012699207 @default.
- W2789871513 cites W2032445035 @default.
- W2789871513 cites W2046281968 @default.
- W2789871513 cites W2050757099 @default.
- W2789871513 cites W2061409791 @default.
- W2789871513 cites W2066375601 @default.
- W2789871513 cites W2068650301 @default.
- W2789871513 cites W2088789809 @default.
- W2789871513 cites W2117053752 @default.
- W2789871513 cites W2126744966 @default.
- W2789871513 cites W2142288396 @default.
- W2789871513 cites W2146583956 @default.
- W2789871513 cites W2789746499 @default.
- W2789871513 doi "https://doi.org/10.1016/j.transproceed.2018.02.108" @default.
- W2789871513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30056895" @default.
- W2789871513 hasPublicationYear "2018" @default.
- W2789871513 type Work @default.
- W2789871513 sameAs 2789871513 @default.
- W2789871513 citedByCount "3" @default.
- W2789871513 countsByYear W27898715132018 @default.
- W2789871513 countsByYear W27898715132019 @default.
- W2789871513 countsByYear W27898715132021 @default.
- W2789871513 crossrefType "journal-article" @default.
- W2789871513 hasAuthorship W2789871513A5044605455 @default.
- W2789871513 hasAuthorship W2789871513A5045517198 @default.
- W2789871513 hasAuthorship W2789871513A5048565684 @default.
- W2789871513 hasAuthorship W2789871513A5083292468 @default.
- W2789871513 hasAuthorship W2789871513A5087571503 @default.
- W2789871513 hasConcept C126322002 @default.
- W2789871513 hasConcept C126894567 @default.
- W2789871513 hasConcept C159641895 @default.
- W2789871513 hasConcept C2777288759 @default.
- W2789871513 hasConcept C2781413609 @default.
- W2789871513 hasConcept C2909675724 @default.
- W2789871513 hasConcept C2911091166 @default.
- W2789871513 hasConcept C31785415 @default.
- W2789871513 hasConcept C44249647 @default.
- W2789871513 hasConcept C71924100 @default.
- W2789871513 hasConcept C72563966 @default.
- W2789871513 hasConceptScore W2789871513C126322002 @default.
- W2789871513 hasConceptScore W2789871513C126894567 @default.
- W2789871513 hasConceptScore W2789871513C159641895 @default.
- W2789871513 hasConceptScore W2789871513C2777288759 @default.
- W2789871513 hasConceptScore W2789871513C2781413609 @default.
- W2789871513 hasConceptScore W2789871513C2909675724 @default.
- W2789871513 hasConceptScore W2789871513C2911091166 @default.
- W2789871513 hasConceptScore W2789871513C31785415 @default.
- W2789871513 hasConceptScore W2789871513C44249647 @default.
- W2789871513 hasConceptScore W2789871513C71924100 @default.
- W2789871513 hasConceptScore W2789871513C72563966 @default.
- W2789871513 hasLocation W27898715131 @default.
- W2789871513 hasLocation W27898715132 @default.
- W2789871513 hasOpenAccess W2789871513 @default.
- W2789871513 hasPrimaryLocation W27898715131 @default.
- W2789871513 hasRelatedWork W1995894256 @default.
- W2789871513 hasRelatedWork W1999402843 @default.
- W2789871513 hasRelatedWork W2025998493 @default.
- W2789871513 hasRelatedWork W2042942731 @default.
- W2789871513 hasRelatedWork W2084265116 @default.
- W2789871513 hasRelatedWork W2239759721 @default.
- W2789871513 hasRelatedWork W2315163783 @default.
- W2789871513 hasRelatedWork W2600903093 @default.
- W2789871513 hasRelatedWork W2896370738 @default.
- W2789871513 hasRelatedWork W3162193073 @default.
- W2789871513 isParatext "false" @default.
- W2789871513 isRetracted "false" @default.
- W2789871513 magId "2789871513" @default.
- W2789871513 workType "article" @default.