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- W2789872472 endingPage "1736" @default.
- W2789872472 startingPage "1723" @default.
- W2789872472 abstract "Zika virus (ZIKV) belongs to the positive-sense single-stranded RNA-containing Flaviviridae family. Its recent outbreak and association with human diseases (e.g. neurological disorders) have raised global health concerns, and an urgency to develop a therapeutic strategy against ZIKV infection. However, there is no currently approved antiviral against ZIKV. Here we present a comprehensive overview on recent progress in structure-function investigation of ZIKV NS5 protein, the largest non-structural protein of ZIKV, which is responsible for replication of the viral genome, RNA capping and suppression of host interferon responses. Structural comparison of the N-terminal methyltransferase domain and C-terminal RNA-dependent RNA polymerase domain of ZIKV NS5 with their counterparts from related viruses provides mechanistic insights into ZIKV NS5-mediated RNA replication, and identifies residues critical for its enzymatic activities. Finally, a collection of recently identified small molecule inhibitors against ZIKV NS5 or its closely related flavivirus homologues are also discussed." @default.
- W2789872472 created "2018-03-29" @default.
- W2789872472 creator A5024171279 @default.
- W2789872472 creator A5040539359 @default.
- W2789872472 creator A5059549236 @default.
- W2789872472 creator A5084096966 @default.
- W2789872472 date "2018-02-08" @default.
- W2789872472 modified "2023-10-07" @default.
- W2789872472 title "Structure and function of Zika virus NS5 protein: perspectives for drug design" @default.
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