FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789872826> ?p ?o ?g. }

• W2789872826 endingPage "8" @default.
• W2789872826 startingPage "1" @default.
• W2789872826 abstract "Wnt5a is a highly studied member of the Wnt family and recently has been implicated in the pathogenesis of atherosclerosis, but its precise role is unknown. Foam cell development is a critical process to atherosclerotic plaque formation. In the present study, we investigated the role of noncanonical Wnt5a signaling in the development of foam cells. Human carotid atherosclerotic tissue and THP-1-derived macrophages were used to investigate the contribution of Wnt5a signaling in the formation of foam cells. Immunohistochemistry was used to evaluate protein expression of scavenger receptors and noncanonical Wnt5a receptors [frizzled 5 (Fz5) and receptor tyrosine kinase-like orphan receptor 2 (Ror2)] in human atherosclerotic macrophages/foam cells. Changes in protein expression in response to Wnt5a stimulation/inhibition were determined by Western blot, and lipid accumulation was evaluated by fluorescent lipid droplet staining. Wnt5a (P<.05), Fz5 (P<.01), and Ror2 (P<.01) were significantly expressed in advanced atherosclerotic lesions compared to less advanced lesions (N=10). Wnt5a, Fz5, and Ror2 were expressed in macrophages/foam cells within the plaque. In vitro studies revealed that Wnt5a significantly increased the expression of the lipid uptake receptor CD36 (P<.05) but not the lipid efflux receptor ATP-binding cassette transporter (P>.05). rWnt5a also significantly increased lipid accumulation in THP-1 macrophages (P<.05). Furthermore, inhibition of Wnt5a signaling with Box5 prevented lipid accumulation (P<.01) and prevented CD36 up-regulation (P<.01). These results suggest a direct role for Wnt5a signaling in the pathogenesis of atherosclerosis, specifically the accumulation of lipid in macrophages and the formation of foam cells." @default.
• W2789872826 created "2018-03-29" @default.
• W2789872826 creator A5002140545 @default.
• W2789872826 creator A5003079614 @default.
• W2789872826 creator A5022036128 @default.
• W2789872826 creator A5033466226 @default.
• W2789872826 creator A5044037437 @default.
• W2789872826 creator A5049540949 @default.
• W2789872826 date "2018-05-01" @default.
• W2789872826 modified "2023-09-26" @default.
• W2789872826 title "Blocking Wnt5a signaling decreases CD36 expression and foam cell formation in atherosclerosis" @default.
• W2789872826 cites W1496691333 @default.
• W2789872826 cites W1971196026 @default.
• W2789872826 cites W1983712244 @default.
• W2789872826 cites W1994600843 @default.
• W2789872826 cites W2002812554 @default.
• W2789872826 cites W2013899166 @default.
• W2789872826 cites W2020094470 @default.
• W2789872826 cites W2024590882 @default.
• W2789872826 cites W2048935593 @default.
• W2789872826 cites W2060766291 @default.
• W2789872826 cites W2064680449 @default.
• W2789872826 cites W2069541735 @default.
• W2789872826 cites W2070291679 @default.
• W2789872826 cites W2080509277 @default.
• W2789872826 cites W2082574041 @default.
• W2789872826 cites W2083825099 @default.
• W2789872826 cites W2099431667 @default.
• W2789872826 cites W2107664383 @default.
• W2789872826 cites W2108110626 @default.
• W2789872826 cites W2113263838 @default.
• W2789872826 cites W2115268091 @default.
• W2789872826 cites W2124485554 @default.
• W2789872826 cites W2124701846 @default.
• W2789872826 cites W2128594838 @default.
• W2789872826 cites W2129909114 @default.
• W2789872826 cites W2135069549 @default.
• W2789872826 cites W2135873877 @default.
• W2789872826 cites W2141140780 @default.
• W2789872826 cites W2142484500 @default.
• W2789872826 cites W2152918946 @default.
• W2789872826 cites W2153245546 @default.
• W2789872826 cites W2157374802 @default.
• W2789872826 cites W2158673376 @default.
• W2789872826 cites W2160094856 @default.
• W2789872826 cites W2167194033 @default.
• W2789872826 cites W2253944974 @default.
• W2789872826 cites W2280206972 @default.
• W2789872826 cites W2590425124 @default.
• W2789872826 cites W2917462181 @default.
• W2789872826 cites W4240900378 @default.
• W2789872826 doi "https://doi.org/10.1016/j.carpath.2018.01.008" @default.
• W2789872826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29474941" @default.
• W2789872826 hasPublicationYear "2018" @default.
• W2789872826 type Work @default.
• W2789872826 sameAs 2789872826 @default.
• W2789872826 citedByCount "27" @default.
• W2789872826 countsByYear W27898728262018 @default.
• W2789872826 countsByYear W27898728262019 @default.
• W2789872826 countsByYear W27898728262020 @default.
• W2789872826 countsByYear W27898728262021 @default.
• W2789872826 countsByYear W27898728262022 @default.
• W2789872826 countsByYear W27898728262023 @default.
• W2789872826 crossrefType "journal-article" @default.
• W2789872826 hasAuthorship W2789872826A5002140545 @default.
• W2789872826 hasAuthorship W2789872826A5003079614 @default.
• W2789872826 hasAuthorship W2789872826A5022036128 @default.
• W2789872826 hasAuthorship W2789872826A5033466226 @default.
• W2789872826 hasAuthorship W2789872826A5044037437 @default.
• W2789872826 hasAuthorship W2789872826A5049540949 @default.
• W2789872826 hasConcept C107300179 @default.
• W2789872826 hasConcept C134018914 @default.
• W2789872826 hasConcept C137620995 @default.
• W2789872826 hasConcept C170493617 @default.
• W2789872826 hasConcept C185592680 @default.
• W2789872826 hasConcept C202751555 @default.
• W2789872826 hasConcept C203014093 @default.
• W2789872826 hasConcept C2777895019 @default.
• W2789872826 hasConcept C2778163477 @default.
• W2789872826 hasConcept C2779244956 @default.
• W2789872826 hasConcept C2779828298 @default.
• W2789872826 hasConcept C2780072125 @default.
• W2789872826 hasConcept C2780942790 @default.
• W2789872826 hasConcept C41443022 @default.
• W2789872826 hasConcept C55493867 @default.
• W2789872826 hasConcept C62478195 @default.
• W2789872826 hasConcept C86803240 @default.
• W2789872826 hasConcept C95444343 @default.
• W2789872826 hasConceptScore W2789872826C107300179 @default.
• W2789872826 hasConceptScore W2789872826C134018914 @default.
• W2789872826 hasConceptScore W2789872826C137620995 @default.
• W2789872826 hasConceptScore W2789872826C170493617 @default.
• W2789872826 hasConceptScore W2789872826C185592680 @default.
• W2789872826 hasConceptScore W2789872826C202751555 @default.
• W2789872826 hasConceptScore W2789872826C203014093 @default.
• W2789872826 hasConceptScore W2789872826C2777895019 @default.
• W2789872826 hasConceptScore W2789872826C2778163477 @default.
• W2789872826 hasConceptScore W2789872826C2779244956 @default.

• next