FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789885586> ?p ?o ?g. }

• W2789885586 endingPage "103" @default.
• W2789885586 startingPage "92" @default.
• W2789885586 abstract "Abstract Background Over the past two decades, parallel recognition has grown of the importance of both sex steroids and immune activity in metabolic regulation. More recently, these discrete areas have been integrated in studies examining the metabolic effects of sex steroid immunomodulation. Implicit in these studies has been a traditional, endocrine model of sex steroid delivery from the gonads to target cells, including immune cells. Thus, research to date has focused on the metabolic effects of sex steroid receptor signaling in immune cells. This endocrine model, however, overlooks the extensive capacity of immune cells to generate and metabolize sex steroids, enabling the production of sex steroids for intracrine signaling – that is, sex steroid production for signaling within the cell of origin. Intracrine function allows highly cell-autonomous regulation of sex steroid exposure, and sex steroid secretion by immune cells could confer paracrine signaling effects in neighboring cells within metabolic tissues. In this review, immune cell intracrinology will denote sex steroid production within immune cells for either intracrine or paracrine signaling. This intracrine capacity of immune cells has been well established, and prior work has supported its importance in autoimmune disorders, trauma, and cancer. The potential relevance of immune cell intracrine function to the regulation of energy balance, body weight, body composition, and insulin sensitivity has yet to be explored. Scope of review The following review will detail findings to date regarding the steroidogenic and steroid metabolizing capacity of immune cells, the regulation of immune cell intracrine function, and the biological effects of immune-derived sex steroids, including the clinical relevance of immune cell intracrinology in fields other than metabolism. These findings will serve as the basis for a proposed model of immune cell intracrinology constituting a new frontier in metabolism research. Major conclusions The development of highly sensitive mass spectrometric methods for sex steroid measurement and quantitation of metabolic flux now allows unprecedented ability to interrogate sex steroid production, metabolism and secretion by immune cells. Immune cell intracrinology could reveal key mechanisms underlying immune cell-mediated metabolic regulation." @default.
• W2789885586 created "2018-03-29" @default.
• W2789885586 creator A5074929020 @default.
• W2789885586 date "2018-09-01" @default.
• W2789885586 modified "2023-09-30" @default.
• W2789885586 title "An intracrine view of sex steroids, immunity, and metabolic regulation" @default.
• W2789885586 cites W1475381583 @default.
• W2789885586 cites W1489568108 @default.
• W2789885586 cites W1521908242 @default.
• W2789885586 cites W1544346946 @default.
• W2789885586 cites W1794866312 @default.
• W2789885586 cites W1863098067 @default.
• W2789885586 cites W19388397 @default.
• W2789885586 cites W1966888232 @default.
• W2789885586 cites W1967333454 @default.
• W2789885586 cites W1969061052 @default.
• W2789885586 cites W1971003548 @default.
• W2789885586 cites W1972022326 @default.
• W2789885586 cites W1976504567 @default.
• W2789885586 cites W1977514238 @default.
• W2789885586 cites W1978299680 @default.
• W2789885586 cites W1979636784 @default.
• W2789885586 cites W1980062349 @default.
• W2789885586 cites W1984104244 @default.
• W2789885586 cites W1984180403 @default.
• W2789885586 cites W1988978834 @default.
• W2789885586 cites W1994169278 @default.
• W2789885586 cites W1994479220 @default.
• W2789885586 cites W1994619498 @default.
• W2789885586 cites W1997613626 @default.
• W2789885586 cites W1997816507 @default.
• W2789885586 cites W1998069116 @default.
• W2789885586 cites W1998186490 @default.
• W2789885586 cites W1999861795 @default.
• W2789885586 cites W2000467286 @default.
• W2789885586 cites W2001513806 @default.
• W2789885586 cites W2004181696 @default.
• W2789885586 cites W2005535905 @default.
• W2789885586 cites W2006398865 @default.
• W2789885586 cites W2009784600 @default.
• W2789885586 cites W2023901889 @default.
• W2789885586 cites W2029397924 @default.
• W2789885586 cites W2031028803 @default.
• W2789885586 cites W2036032721 @default.
• W2789885586 cites W2036071320 @default.
• W2789885586 cites W2037725361 @default.
• W2789885586 cites W2039911931 @default.
• W2789885586 cites W2040012853 @default.
• W2789885586 cites W2041451931 @default.
• W2789885586 cites W2041939368 @default.
• W2789885586 cites W2042580589 @default.
• W2789885586 cites W2045019335 @default.
• W2789885586 cites W2045688706 @default.
• W2789885586 cites W2050847082 @default.
• W2789885586 cites W2054033355 @default.
• W2789885586 cites W2054413572 @default.
• W2789885586 cites W2056273868 @default.
• W2789885586 cites W2057196832 @default.
• W2789885586 cites W2057859584 @default.
• W2789885586 cites W2060253930 @default.
• W2789885586 cites W2063107672 @default.
• W2789885586 cites W2063663291 @default.
• W2789885586 cites W2066606063 @default.
• W2789885586 cites W2069680266 @default.
• W2789885586 cites W2072510263 @default.
• W2789885586 cites W2072744994 @default.
• W2789885586 cites W2074074395 @default.
• W2789885586 cites W2075582753 @default.
• W2789885586 cites W2077420563 @default.
• W2789885586 cites W2082897031 @default.
• W2789885586 cites W2086888830 @default.
• W2789885586 cites W2087685430 @default.
• W2789885586 cites W2090255089 @default.
• W2789885586 cites W2092886186 @default.
• W2789885586 cites W2093199988 @default.
• W2789885586 cites W2095296616 @default.
• W2789885586 cites W2097354225 @default.
• W2789885586 cites W2103911945 @default.
• W2789885586 cites W2103934194 @default.
• W2789885586 cites W2107416858 @default.
• W2789885586 cites W2107786108 @default.
• W2789885586 cites W2108848837 @default.
• W2789885586 cites W2109148379 @default.
• W2789885586 cites W2119039069 @default.
• W2789885586 cites W2119742360 @default.
• W2789885586 cites W2120787606 @default.
• W2789885586 cites W2124080367 @default.
• W2789885586 cites W2124384011 @default.
• W2789885586 cites W2125154694 @default.
• W2789885586 cites W2126128710 @default.
• W2789885586 cites W2130419288 @default.
• W2789885586 cites W2130662388 @default.
• W2789885586 cites W2131506523 @default.
• W2789885586 cites W2133626354 @default.
• W2789885586 cites W2137801083 @default.
• W2789885586 cites W2137996608 @default.
• W2789885586 cites W2139036375 @default.
• W2789885586 cites W2145430890 @default.

• next