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• W2789926559 abstract "Abstract BACKGROUND Poly(hydroxyalkanoates) (PHAs) are biodegradable polymers that can replace conventional plastics, but microbial production of PHAs must be optimized for commercial success. The aim of this study is to provide a simple mathematical model based on previous studies in the literature to represent the production of PHAs in chemostat and batch cultures by Pseudomonas putida GPo1 (ATCC 29347) and Cupriavidus necator (DSM 545) grown on octanoate and glucose, respectively. RESULTS Kinetic and stoichiometric equations, dependent on the specific growth rate of residual biomass (µ R ), were developed for carbon‐ and nitrogen‐limiting growth conditions. The parameters have biochemical significance and are independent of the biomass concentration. The results revealed that the Luedeking–Piret model is growth‐associated for both fermentations under carbon limitation. In addition, the PHA content increases with µ R . Meanwhile, the PHA content is amplified under nitrogen limitation but decreases as μ R increases. Also, the Luedeking–Piret model exhibits a profile that depends on the synthesized polyhydroxyalkanoate. CONCLUSION This study demonstrates that strategies for the production of PHAs require an in‐depth understanding of the process kinetics. This model gives satisfactory predictions, may be extended to fed batch cultures and may be adapted to other fermentations. © 2018 Society of Chemical Industry" @default.
• W2789926559 created "2018-03-29" @default.
• W2789926559 creator A5039752507 @default.
• W2789926559 creator A5041331244 @default.
• W2789926559 date "2018-04-14" @default.
• W2789926559 modified "2023-10-01" @default.
• W2789926559 title "A simple mathematical model capable of describing the microbial production of poly(hydroxyalkanoates) under carbon- and nitrogen-limiting growth conditions" @default.
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• W2789926559 doi "https://doi.org/10.1002/jctb.5610" @default.
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